METHYL THIOSALICYLATE
- Product Name
- METHYL THIOSALICYLATE
- CAS No.
- 4892-02-8
- Chemical Name
- METHYL THIOSALICYLATE
- Synonyms
- METHYL 2-MERCAPTOBENZOATE;CL058;thiosaL;NSC 30156;USAF ma-15;METHYL THIOSALICYLAT;METHYL THIOSALICYLATE;Methyl 2-Thiosalicylate;MethylThiosalicylate>Methyl ar-thiosalicylate
- CBNumber
- CB7350036
- Molecular Formula
- C8H8O2S
- Formula Weight
- 168.21
- MOL File
- 4892-02-8.mol
METHYL THIOSALICYLATE Property
- Melting point:
- 164 °C
- Boiling point:
- 98-100 °C/2 mmHg (lit.)
- Density
- 1.223 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.591(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 5.84±0.43(Predicted)
- form
- Liquid
- Specific Gravity
- 1.223
- color
- Clear colorless to light yellow or light green
- Sensitive
- Air Sensitive
- Stability:
- Air Sensitive
- InChI
- InChI=1S/C8H8O2S/c1-10-8(9)6-4-2-3-5-7(6)11/h2-5,11H,1H3
- InChIKey
- BAQGCWNPCFABAY-UHFFFAOYSA-N
- SMILES
- C(OC)(=O)C1=CC=CC=C1S
- CAS DataBase Reference
- 4892-02-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- RTECS
- DH3500000
- HazardClass
- IRRITANT
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 357758
- Product name
- Methyl thiosalicylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $74.2
- Updated
- 2025/07/31
- Product number
- 357758
- Product name
- Methyl thiosalicylate
- Purity
- 97%
- Packaging
- 25g
- Price
- $250.67
- Updated
- 2025/07/31
- Product number
- M1881
- Product name
- Methyl Thiosalicylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $87
- Updated
- 2025/07/31
- Product number
- M1881
- Product name
- Methyl Thiosalicylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $267
- Updated
- 2025/07/31
- Product number
- M320710
- Product name
- Methyl2-Mercaptobenzoate
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
METHYL THIOSALICYLATE Chemical Properties,Usage,Production
Chemical Properties
clear colorless to light yellow or light green
Uses
Methyl 2-Mercaptobenzoate (cas# 4892-02-8) is a compound useful in organic synthesis.
Uses
Methyl thiosalicylate may be used:
- in the synthesis of thioxanthone, an efficient enantioselective organocatalyst for the intramolecular [2+2] photocycloaddition reaction
- as anionic bidentate ligand, in the preparation of ′2+1′ type complexes of [(99m)Tc]-tricarbonyltechnetium(I) and [(188)Re]-tricarbonylrhenium(I)
- in the synthesis of a series of benzisothiazolone derivatives
- in the synthesis of a new fused benzoheterocyclic compound, [1]benzothieno[3,2-b]furan
General Description
Methyl thiosalicylate may be benefecial in preventing mercury-induced toxicity.
Synthesis
67-56-1
147-93-3
4892-02-8
Example 1: Preparation of methyl 2-[6-(1-bromo-ethyl)-5-fluoropyrimidin-4-yl-thioalkyl]benzoate (Preparation of compounds of formula 2 with o-CO2CH3 substitution); Step 1) Preparation of methyl 2-mercaptobenzoate: 40 g of 2-mercaptobenzoic acid was dissolved in 600 mL of methanol, and cooled to 5°C. 42 mL of concentrated sulfuric acid was added slowly and dropwise over a 10 minute period. The reaction mixture was reacted under reflux conditions for 14 hours and then concentrated under reduced pressure. The concentrate was diluted with 400 mL of dichloromethane and 400 mL of pure water and the organic layer was subsequently separated. The organic layer was washed sequentially with 200 mL of saturated sodium bicarbonate solution and 400 mL of saturated brine, and then dried with anhydrous sodium sulfate. After drying, the organic layer was concentrated to give the crude product, which was further purified by fractional distillation (118°C/7 mmHg). Finally, 42 g (yield: 96%) of methyl thiosalicylate was obtained as a clear oil.1H-NMR (200 MHz, CDCl3) δ (ppm): 8.01 (d, 1H), 7.30 (d, 2H), 7.14 (m, 1H), 4.68 (s, 1H), 3.91 (s, 3H).
References
[1] Patent: EP2444398, 2012, A2. Location in patent: Page/Page column 9
[2] Tetrahedron, 2017, vol. 73, # 13, p. 1745 - 1761
[3] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 62
[4] Journal of Medicinal Chemistry, 2018,
[5] Patent: US2007/167497, 2007, A1. Location in patent: Page/Page column 28
METHYL THIOSALICYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL THIOSALICYLATE manufacturers
- Product
- METHYL THIOSALICYLATE 4892-02-8
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16
- Product
- METHYL THIOSALICYLATE 4892-02-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- METHYL THIOSALICYLATE 4892-02-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-05