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METHYL THIOSALICYLATE

Product Name
METHYL THIOSALICYLATE
CAS No.
4892-02-8
Chemical Name
METHYL THIOSALICYLATE
Synonyms
METHYL 2-MERCAPTOBENZOATE;CL058;thiosaL;NSC 30156;USAF ma-15;METHYL THIOSALICYLAT;METHYL THIOSALICYLATE;Methyl 2-Thiosalicylate;MethylThiosalicylate>Methyl ar-thiosalicylate
CBNumber
CB7350036
Molecular Formula
C8H8O2S
Formula Weight
168.21
MOL File
4892-02-8.mol
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METHYL THIOSALICYLATE Property

Melting point:
164 °C
Boiling point:
98-100 °C/2 mmHg (lit.)
Density 
1.223 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.591(lit.)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
5.84±0.43(Predicted)
form 
Liquid
Specific Gravity
1.223
color 
Clear colorless to light yellow or light green
Sensitive 
Air Sensitive
Stability:
Air Sensitive
InChI
InChI=1S/C8H8O2S/c1-10-8(9)6-4-2-3-5-7(6)11/h2-5,11H,1H3
InChIKey
BAQGCWNPCFABAY-UHFFFAOYSA-N
SMILES
C(OC)(=O)C1=CC=CC=C1S
CAS DataBase Reference
4892-02-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
RTECS 
DH3500000
HazardClass 
IRRITANT
HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
357758
Product name
Methyl thiosalicylate
Purity
97%
Packaging
5g
Price
$74.2
Updated
2025/07/31
Sigma-Aldrich
Product number
357758
Product name
Methyl thiosalicylate
Purity
97%
Packaging
25g
Price
$250.67
Updated
2025/07/31
TCI Chemical
Product number
M1881
Product name
Methyl Thiosalicylate
Purity
>98.0%(GC)
Packaging
5g
Price
$87
Updated
2025/07/31
TCI Chemical
Product number
M1881
Product name
Methyl Thiosalicylate
Purity
>98.0%(GC)
Packaging
25g
Price
$267
Updated
2025/07/31
TRC
Product number
M320710
Product name
Methyl2-Mercaptobenzoate
Packaging
5g
Price
$85
Updated
2021/12/16
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METHYL THIOSALICYLATE Chemical Properties,Usage,Production

Chemical Properties

clear colorless to light yellow or light green

Uses

Methyl 2-Mercaptobenzoate (cas# 4892-02-8) is a compound useful in organic synthesis.

Uses

Methyl thiosalicylate may be used:

  • in the synthesis of thioxanthone, an efficient enantioselective organocatalyst for the intramolecular [2+2] photocycloaddition reaction
  • as anionic bidentate ligand, in the preparation of ′2+1′ type complexes of [(99m)Tc]-tricarbonyltechnetium(I) and [(188)Re]-tricarbonylrhenium(I)
  • in the synthesis of a series of benzisothiazolone derivatives
  • in the synthesis of a new fused benzoheterocyclic compound, [1]benzothieno[3,2-b]furan

General Description

Methyl thiosalicylate may be benefecial in preventing mercury-induced toxicity.

Synthesis

67-56-1

147-93-3

4892-02-8

Example 1: Preparation of methyl 2-[6-(1-bromo-ethyl)-5-fluoropyrimidin-4-yl-thioalkyl]benzoate (Preparation of compounds of formula 2 with o-CO2CH3 substitution); Step 1) Preparation of methyl 2-mercaptobenzoate: 40 g of 2-mercaptobenzoic acid was dissolved in 600 mL of methanol, and cooled to 5°C. 42 mL of concentrated sulfuric acid was added slowly and dropwise over a 10 minute period. The reaction mixture was reacted under reflux conditions for 14 hours and then concentrated under reduced pressure. The concentrate was diluted with 400 mL of dichloromethane and 400 mL of pure water and the organic layer was subsequently separated. The organic layer was washed sequentially with 200 mL of saturated sodium bicarbonate solution and 400 mL of saturated brine, and then dried with anhydrous sodium sulfate. After drying, the organic layer was concentrated to give the crude product, which was further purified by fractional distillation (118°C/7 mmHg). Finally, 42 g (yield: 96%) of methyl thiosalicylate was obtained as a clear oil.1H-NMR (200 MHz, CDCl3) δ (ppm): 8.01 (d, 1H), 7.30 (d, 2H), 7.14 (m, 1H), 4.68 (s, 1H), 3.91 (s, 3H).

References

[1] Patent: EP2444398, 2012, A2. Location in patent: Page/Page column 9
[2] Tetrahedron, 2017, vol. 73, # 13, p. 1745 - 1761
[3] Patent: WO2013/64231, 2013, A1. Location in patent: Page/Page column 62
[4] Journal of Medicinal Chemistry, 2018,
[5] Patent: US2007/167497, 2007, A1. Location in patent: Page/Page column 28

METHYL THIOSALICYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL THIOSALICYLATE Suppliers

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View Lastest Price from METHYL THIOSALICYLATE manufacturers

Henan Fengda Chemical Co., Ltd
Product
METHYL THIOSALICYLATE 4892-02-8
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
METHYL THIOSALICYLATE 4892-02-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Nanjing jinheyou Trading Co., Ltd.
Product
METHYL THIOSALICYLATE 4892-02-8
Price
US $0.00/g
Min. Order
1g
Purity
98%min
Supply Ability
20kg/month
Release date
2019-11-05

4892-02-8, METHYL THIOSALICYLATERelated Search:

Methyl salicylate Furfuryl thioacetate Sodium sulfite Thioacetamide Potassium thioacetate NA METSULFURON METHYL Sulfometuron-methyl Methyl 2-(chlorosulfonyl)benzoate 2-Carbomethoxybenzenesulfonamide Thiosalicylic acid METHYL 2-(METHYLTHIO)BENZOATE Chlorimuron-ethyl METHYL THIOSALICYLATE METHYL 2-[(CYANOMETHYL)THIO]BENZOATE dimethyl 2,2'-dithiobisbenzoate METHYL 2-[(CYANOMETHYL)SULFONYL]BENZOATE 5-[(2-METHOXYCARBONYL)PHENYLTHIO]-1-METHYL-3-(TRIFLUOROMETHYLPYRAZOLE)-4-CARBOXALDEHYDE

  • METHYL THIOSALICYLAT
  • Methyl 2-Thiosalicylate
  • NSC 30156
  • o-Mercapto-benzoic Acid Methyl Ester
  • Thiosalicylic Acid Methyl Ester Methyl 2-Mercaptobenzoate 2-Mercaptobenzoic Acid Methyl Ester
  • 2-Mercaptobenzoic acid methyl
  • Methyl thiosalicylate,97%
  • Methylethiosalicylate, 97%
  • 2-(methoxycarbonyl)thiophenol
  • METHYL 2-MERCAPTOBENZOATE
  • METHYL THIOSALICYLATE
  • 2-MERCAPTOBENZOIC ACID METHYL ESTER
  • CL058
  • 2-mercapto-benzoicacimethylester
  • Benzoic acid, 2-mercapto-, methyl ester
  • Methyl 2-sulfanylbenzoate
  • Methyl ar-thiosalicylate
  • Methyl o-mercaptobenzoate
  • methyl-o-mercaptobenzoate
  • o-mercapto-benzoicacimethylester
  • USAF ma-15
  • thiosaL
  • MethylThiosalicylate&gt
  • 4892-02-8
  • 4892-20-8
  • 2/8/4892
  • HSC6H4CO2CH3
  • Building Blocks
  • Organic Building Blocks
  • Sulfur Compounds
  • Thiols/Mercaptans
  • fine chemicals
  • Organics
  • Metal Isotopes
  • Sulfur & Selenium Compounds