PHENYLMERCURIC NITRATE Property

Melting point:

175-185 °C (dec.) (lit.)

vapor pressure 

0.0000019 hPa at 20°C

storage temp. 

Store below +30°C.

form 

Solid

color 

White crystalline

PH Range

6.6

Water Solubility 

soluble ~1250 parts H2O; slightly soluble alcohol [MER06]

Merck 

14,7302

CAS DataBase Reference

8003-05-2(CAS DataBase Reference)

Safety

Hazard Codes 

T,N

Risk Statements 

25-34-48/24/25-50/53

Safety Statements 

23-24/25-37-45-60-61

RIDADR 

UN 1895 6.1/PG 2

WGK Germany 

3

RTECS 

OW8575000

HazardClass 

6.1

PackingGroup 

II

HS Code 

28521000

Toxicity

LD50 in mice (mg/g): 0.045 s.c.; 0.027 i.v. (Wien)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P501Dispose of contents/container to..…

PHENYLMERCURIC NITRATE Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Pharmaceutic aid (antimicrobial). Tree wound dressing.

General Description

Phenylmercury nitrate is a mercury-based organic compound known to have antibacterial and antifungal activities. It is also used as a preservative for parenteral injections.

Clinical Use

Phenylmercuric nitrate is a mixture of phenylmercuric nitrateand phenylmercuric hydroxide. It occurs as a whitecrystalline material that is sparingly soluble in water andslightly soluble in alcohol. It is used in concentrations of1:10,000 to 1:50,000 to preserve injectable drugs againstbacterial contamination. A disadvantage to organomercurialsis that their bacteriostatic efficacy is reduced in the presenceof serum.

Purification Methods

When recrystallised from water or aqueous EtOH, it has m 191-191.5o, and from 95% EtOH it has m 186.5o [Challanger & Rothstein J Chem Soc I 1258 1934]. When recrystallised from *C6H6 or CHCl3, it has m 131-131.5o [Morton et al. J Am Chem Soc 69 908 1947.] [Beilstein 16 III 1348, 16 IV 1721.]