11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Related substances

Product Name: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
CAS No.: 13951-70-7
Chemical Name: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms: 16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04
CBNumber: CB7352308
Molecular Formula: C21H28O6
Formula Weight: 376.44
MOL File: 13951-70-7.mol

More

Less

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Property

Melting point:: 235-238°C
Boiling point:: 591.5±50.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 11.93±0.70(Predicted)
color: White to Light Yellow
Water Solubility: 815mg/L at 20℃
LogP: 0.8 at 25℃
CAS DataBase Reference: 13951-70-7(CAS DataBase Reference)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 25g
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 5g
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 10g
Price: $243
Updated: 2024/03/01

TRC

Product number: T296075
Product name: 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
Packaging: 500mg
Price: $245
Updated: 2021/12/16

More

Less

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Related substances

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.

Chemical Properties

White Crystalline Solid

Uses

A metabolite of Budesonide (B689490), an antiinflammatory agent.

Uses

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

Canada 2 China 296 Europe 2 India 14 The Netherlands 1 United Kingdom 5 United States 19 Global 339

Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd

Tel: 010-56380788-8515 16619769925
Email: wch013@bionna.cn
Country: China
ProdList: 53
Advantage: 58

Hubei YiKangYuan Chemical Co., Ltd.

Tel: 027-87182908 18064088908
Fax: 027-87182900
Email: 65824125@qq.com
Country: China
ProdList: 91
Advantage: 55

Jinan Wald Chemical Co., Ltd.

Tel: 0531-88773586 13210588999
Fax: 053188773586
Email: 304264064@qq.com
Country: China
ProdList: 193
Advantage: 58

Shandong Yuhe Pharmaceutical Technology Co., LTD

Tel: 15263077727
Fax: QQ：2938966534
Email: 1436425847@qq.com
Country: China
ProdList: 163
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: zhangsn@titansci.com
Country: China
ProdList: 14113
Advantage: 59

More

Less

View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-12-01

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7
Price: US $80.00-800.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-06

Wuhan Senwayer Century Chemical Co.,Ltd

Product: 16alpha-Hydroxyprednisolone 13951-70-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 20 tons
Release date: 2022-12-08

13951-70-7, 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dioneRelated Search:

Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide (r)-budesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Ciclesonide

16A-HYDROXY-PREDNISONLONE

11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

16 Alpha Hydroxprednisolone

16α-HYDROXY-PREDNISONLONE

11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione

Einecs 237-731-1

16-ALPHA-HYDROXY PREDNISOLONE

16A-HYDROXY-PREDNISOLONE

11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione

11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE

16a-Hydroxypredisolone

(11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

16α-Hydroxyprednisolon

Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone)

(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

(8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid

Budesonide iMpurit A

Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone)

BNKY015-BD04

16α-hydroxy-prednisolone

Budesonide EP Impurity A

16b

20-dione

21-Tetrahydroxy-pregna-1

4-diene-3

Budesonide impurity A

Budesonide Impurity 1(Budesonide EP Impurity A)

11beta,16alpha,17,21-Tetrahydroxypr

Desonide Impurity A

Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-

16α-hydroxy Prednisolone

11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP

Tmo Trimethylamine N-Oxide Dihydrate Powder

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone)

16α-hydroxy-prednisonlone

16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone

16α-Hydroxyprednisolone-d5

16α-Hydroeyprednisolone

Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-

16α-Hydroxyprednisolone (Budesonide Impurity)

11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione

Desonide EP Impurity-A

11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione

(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

13951-70-7

13952-70-7

Pharmaceutical Raw Materials

Metabolites & Impurities

Intermediates & Fine Chemicals

Metabolites

Pharmaceuticals

Steroids