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ChemicalBook > CAS DataBase List > 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

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Product Name
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
CAS No.
13951-70-7
Chemical Name
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms
16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04
CBNumber
CB7352308
Molecular Formula
C21H28O6
Formula Weight
376.44
MOL File
13951-70-7.mol
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Property

Melting point:
235-238°C
Boiling point:
591.5±50.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
vapor pressure 
0Pa at 25℃
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
11.93±0.70(Predicted)
color 
White to Light Yellow
Water Solubility 
815mg/L at 20℃
LogP
0.8 at 25℃
CAS DataBase Reference
13951-70-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27169
Product name
16α-hydroxy Prednisolone
Packaging
1g
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
27169
Product name
16α-hydroxy Prednisolone
Packaging
25g
Price
$479
Updated
2024/03/01
Cayman Chemical
Product number
27169
Product name
16α-hydroxy Prednisolone
Packaging
5g
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
27169
Product name
16α-hydroxy Prednisolone
Packaging
10g
Price
$243
Updated
2024/03/01
TRC
Product number
T296075
Product name
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
Packaging
500mg
Price
$245
Updated
2021/12/16
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Related substances

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.

Chemical Properties

White Crystalline Solid

Uses

A metabolite of Budesonide (B689490), an antiinflammatory agent.

Uses

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

Bono Kangyuan (Beijing) Pharmaceutical Technology Co., Ltd
Tel
010-56380788-8515 16619769925
Email
wch013@bionna.cn
Country
China
ProdList
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Hubei YiKangYuan Chemical Co., Ltd.
Tel
027-87182908 18064088908
Fax
027-87182900
Email
65824125@qq.com
Country
China
ProdList
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Jinan Wald Chemical Co., Ltd.
Tel
0531-88773586 13210588999
Fax
053188773586
Email
304264064@qq.com
Country
China
ProdList
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Shandong Yuhe Pharmaceutical Technology Co., LTD
Tel
15263077727
Fax
QQ:2938966534
Email
1436425847@qq.com
Country
China
ProdList
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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
Fax
86-21-50328109
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3bsc@sina.com
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China
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ShangHai DEMO Chemical Co.,Ltd
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400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
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66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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Adamas Reagent, Ltd.
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400-6009262 16621234537
Fax
021-64823266
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chenyj@titansci.com
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China
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View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 13951-70-7
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-13
Wuhan Senwayer Century Chemical Co.,Ltd
Product
16alpha-Hydroxyprednisolone 13951-70-7
Price
US $0.00/kg
Min. Order
1kg
Purity
99% HPLC
Supply Ability
20 tons
Release date
2022-12-08
Baoji Guokang Bio-Technology Co., Ltd.
Product
11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7
Price
US $2460.00/KG
Min. Order
500g
Purity
99%
Supply Ability
10000KG
Release date
2021-06-03

13951-70-7, 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dioneRelated Search:


  • 16A-HYDROXY-PREDNISONLONE
  • 11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 16 Alpha Hydroxprednisolone
  • 16α-HYDROXY-PREDNISONLONE
  • 11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione
  • 11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
  • 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
  • Einecs 237-731-1
  • 16-ALPHA-HYDROXY PREDNISOLONE
  • 16A-HYDROXY-PREDNISOLONE
  • 11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione
  • 11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
  • 16a-Hydroxypredisolone
  • (11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
  • 16α-Hydroxyprednisolon
  • Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone)
  • (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione
  • 9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid
  • Budesonide iMpurit A
  • Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone)
  • BNKY015-BD04
  • 16α-hydroxy-prednisolone
  • Budesonide EP Impurity A
  • 16b
  • 20-dione
  • 21-Tetrahydroxy-pregna-1
  • 4-diene-3
  • Budesonide impurity A
  • Budesonide Impurity 1(Budesonide EP Impurity A)
  • 11beta,16alpha,17,21-Tetrahydroxypr
  • Desonide Impurity A
  • Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-
  • 16α-hydroxy Prednisolone
  • 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP
  • Tmo Trimethylamine N-Oxide Dihydrate Powder
  • 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
  • 11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone)
  • 16α-hydroxy-prednisonlone
  • 16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone
  • 16α-Hydroxyprednisolone-d5
  • 16α-Hydroeyprednisolone
  • Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-
  • 16α-Hydroxyprednisolone (Budesonide Impurity)
  • 11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione
  • Desonide EP Impurity-A
  • 11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione
  • 11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione
  • (8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • 13951-70-7
  • 13952-70-7
  • Pharmaceutical Raw Materials
  • Metabolites & Impurities
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals
  • Steroids