11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

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Product Name: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
CAS No.: 13951-70-7
Chemical Name: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Synonyms: 16α-hydroxy-prednisolone;11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04
CBNumber: CB7352308
Molecular Formula: C21H28O6
Formula Weight: 376.44
MOL File: 13951-70-7.mol

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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Property

Melting point:: 235-238°C
Boiling point:: 591.5±50.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
vapor pressure: 0Pa at 25℃
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 11.93±0.70(Predicted)
color: White to Light Yellow
Water Solubility: 815mg/L at 20℃
LogP: 0.8 at 25℃
CAS DataBase Reference: 13951-70-7(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 25g
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 5g
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 27169
Product name: 16α-hydroxy Prednisolone
Packaging: 10g
Price: $243
Updated: 2024/03/01

TRC

Product number: T296075
Product name: 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
Packaging: 500mg
Price: $245
Updated: 2021/12/16

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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production

Related substances

Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.

Chemical Properties

White Crystalline Solid

Uses

A metabolite of Budesonide (B689490), an antiinflammatory agent.

Uses

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.

Synthesis

501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Suppliers

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View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 13951-70-7
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000Ton
Release date: 2024-08-13

Baoji Guokang Bio-Technology Co., Ltd.

Product: 11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione 13951-70-7
Price: US $2460.00/KG
Min. Order: 500g
Purity: 99%
Supply Ability: 10000KG
Release date: 2021-06-03

Wuhan Senwayer Century Chemical Co.,Ltd

Product: 16alpha-Hydroxyprednisolone 13951-70-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99% HPLC
Supply Ability: 20 tons
Release date: 2022-12-08

13951-70-7, 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dioneRelated Search:

Budesonide Sulfate SodiuM (Mixture of DiastereoMers) 14,15-Dehydro Budesonide 9α-BroMobudesonide 16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione (Mixture of DiastereoMers) Desonide Budesonide Di-Norbudesonide (Mixture of DiastereoMers) 9,11-Anhydrobudesonide Budesonide EP Impurity D (Mixture of Diastereomers) 21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione (16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione 1,2-Dehydrobudesonide Budesonide Impurity 1 (Mixture of Diastereomers) Budesonide EP Impurity A-d4 Flunisolide (r)-budesonide 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Ciclesonide

16A-HYDROXY-PREDNISONLONE

11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

16 Alpha Hydroxprednisolone

16α-HYDROXY-PREDNISONLONE

11,16a,17a,21-Tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione

Einecs 237-731-1

16-ALPHA-HYDROXY PREDNISOLONE

16A-HYDROXY-PREDNISOLONE

11a,16b,17,21-tetrahydroxy-pregna-1,4-diene-3,20-dione

11B,16A,17A,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE

16a-Hydroxypredisolone

(11β,16α)-11,16,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

16α-Hydroxyprednisolon

Budesonide IMpurity A (16-alpha-Hydroxy-Prednisolone)

(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

(8S,9S,10R,13S,14S,16R,17S)-11,16,17-Trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one

Prednisolone impurity 1/Prednisolone EP Impurity A/16-alpha-Hydroxy-Prednisolone/11?,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione

9-[3-(1,2-dihydroxyheptyl)-2-oxiranyl]-9-hydroxynonanoic acid

Budesonide iMpurit A

Budesonide EP Impurity A (16-alpha-Hydroxy-Prednisolone)

BNKY015-BD04

16α-hydroxy-prednisolone

Budesonide EP Impurity A

16b

20-dione

21-Tetrahydroxy-pregna-1

4-diene-3

Budesonide impurity A

Budesonide Impurity 1(Budesonide EP Impurity A)

11beta,16alpha,17,21-Tetrahydroxypr

Desonide Impurity A

Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-

16α-hydroxy Prednisolone

11a,16b,17,21-Tetrahydroxy-pregna-1,4-diene-3,20-dione USP/EP/BP

Tmo Trimethylamine N-Oxide Dihydrate Powder

11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione(triamcinolone)

16α-hydroxy-prednisonlone

16 α Hydroxy PrednisoloneQ: What is 16 α Hydroxy Prednisolone Q: What is the CAS Number of 16 α Hydroxy Prednisolone Q: What is the storage condition of 16 α Hydroxy Prednisolone

16α-Hydroxyprednisolone-d5

16α-Hydroeyprednisolone

Pregna-1,4-diene-3,20-dione, 11,16,17,21-tetrahydroxy-, (11β,16α)-

16α-Hydroxyprednisolone (Budesonide Impurity)

11β,16α,17α,21-Tetrahydroxypregnα-1,4-diene-3,20-dione

Desonide EP Impurity-A

11-Beta,16-Alpha,17-Alpha,21-Tetrahydroxypregna-1,4-diene-3,20-dione

11β,16α,17α,21-tetrahydroxyprogesterone-1,4-diene-3,20-dione

(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

13951-70-7

13952-70-7

Pharmaceutical Raw Materials

Metabolites & Impurities

Intermediates & Fine Chemicals

Metabolites

Pharmaceuticals

Steroids