ChemicalBook > CAS DataBase List > 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Related substances- Product Name
- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- CAS No.
- 13951-70-7
- Chemical Name
- 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
- Synonyms
- 16α-hydroxy-prednisolone;11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;(8S,9S,10R,11S,13S,14S,16R,17S)-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one;16-ALPHA-HYDROXY PREDNISOLONE;11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione;16b;20-dione;4-diene-3;BNKY015-BD04;Einecs 237-731-1
- CBNumber
- CB7352308
- Molecular Formula
- C21H28O6
- Formula Weight
- 376.44
- MOL File
- 13951-70-7.mol
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Property
- Melting point:
- 235-238°C
- Boiling point:
- 591.5±50.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- vapor pressure
- 0Pa at 25℃
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 11.93±0.70(Predicted)
- color
- White to Light Yellow
- Water Solubility
- 815mg/L at 20℃
- LogP
- 0.8 at 25℃
- CAS DataBase Reference
- 13951-70-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 27169
- Product name
- 16α-hydroxy Prednisolone
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27169
- Product name
- 16α-hydroxy Prednisolone
- Packaging
- 25g
- Price
- $479
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27169
- Product name
- 16α-hydroxy Prednisolone
- Packaging
- 5g
- Price
- $139
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 27169
- Product name
- 16α-hydroxy Prednisolone
- Packaging
- 10g
- Price
- $243
- Updated
- 2024/03/01
TRC
- Product number
- T296075
- Product name
- 11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione
- Packaging
- 500mg
- Price
- $245
- Updated
- 2021/12/16
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11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Chemical Properties,Usage,Production
Related substances
Prednisolone is a synthetic adrenocortical steroid drug with predominantly glucocorticoid properties.
Chemical Properties
White Crystalline Solid
Uses
A metabolite of Budesonide (B689490), an antiinflammatory agent.
Uses
11β,16α,17α,21-Tetrahydroxypregna-1,4-diene-3,20-dione (Budesonide EP Impurity A) is a metabolite of Budesonide (B689490), an anti-inflammatory agent.
Synthesis
501 g of crude 16α-hydroxy prednisolone acetate is dissolved in 700 ml of dichloromethane and 700 ml of ethanol, then 1.5 ml of formic acid is added, 24 ml of 5% sodium hypochlorite aqueous solution is added dropwise, and the temperature is controlled at 15 °C, and the reaction is stirred to obtain the preliminary processed product; Add 150 ml of 5% sodium bisulfite aqueous solution to the above-mentioned preliminary treatment product, concentrate on removing the solvent, adding water to hydrolyze, and filter to obtain 45 g of 16α-hydroxyprednisolone acetate refined product; 45 g of 16α-hydroxyprednisolone acetate obtained above was dissolved in a mixed organic solvent of 250 ml of dichloromethane and 250 ml of methanol, stirred and cooled to 0 °C, 90 ml of 10% sodium sulfite aqueous solution was added, and the reaction was stirred. After completion, it was neutralized with 15% sulfuric acid by mass concentration; the mixed organic solvent was concentrated, watered out, filtered, and dried to obtain 36.5 g of 16α-hydroxyprednisolone (11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione).
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione manufacturers
Hebei Mujin Biotechnology Co.,Ltd
- Product
- Tmo Trimethylamine N-Oxide Dihydrate Powder 13951-70-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2021-10-09
Hebei Mujin Biotechnology Co.,Ltd
- Product
- 16a-Hydroxyprednisolone 13951-70-7
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 5000kg/month
- Release date
- 2021-10-14
Hebei Mujin Biotechnology Co.,Ltd
- Product
- 16alpha-hydroxyprednisolone 13951-70-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-05-19
13951-70-7, 11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dioneRelated Search:
Budesonide Sulfate SodiuM (Mixture of DiastereoMers)
14,15-Dehydro Budesonide
9α-BroMobudesonide
16α,17-[(1RS)-Butylidenebis(oxy)]-11β-hydroxy-17-(hydroxyMethyl)-D-hoMoandrosta-1,4-diene-3,17a-dione
(Mixture of DiastereoMers)
Desonide
Budesonide
Di-Norbudesonide (Mixture of DiastereoMers)
9,11-Anhydrobudesonide
Budesonide EP Impurity D (Mixture of Diastereomers)
21-Acetoxy-11β-hydroxy-16α,17α-propylmethylenedioxpregna-1,4-diene-3,20-dione
(16α)-16,17-[Butylidenebis(oxy)]-21-hydroxypregna-1,4-diene-3,11,20-trione
1,2-Dehydrobudesonide
Budesonide Impurity 1 (Mixture of Diastereomers)
Budesonide EP Impurity A-d4
Flunisolide
(r)-budesonide
11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione
Ciclesonide