ChemicalBook > CAS DataBase List > 4-Hydroxy-3-nitrobenzonitrile

4-Hydroxy-3-nitrobenzonitrile

Product Name
4-Hydroxy-3-nitrobenzonitrile
CAS No.
3272-08-0
Chemical Name
4-Hydroxy-3-nitrobenzonitrile
Synonyms
2-NITRO-4-CYANOPHENOL;4-CYANO-2-NITROPHENOL;4-cyano-2-nitrophenolate;4-HYDROXY-3-NITROBENZONITRILE;3-Nitro-4-hydroxybenzonitrile;Benzonitrile, 4-hydroxy-3-nitro-;4-HYDROXY-3-NITROBENZONITRILE 97%;4-Hydroxy-3-nitrobenzonitrile,97%;4-BROMO-2,6-DIETHOXY-1-NITROBENZENE;4-Hydroxy-3-nitrobenzonitrile ISO 9001：2015 REACH
CBNumber
CB7363601
Molecular Formula
C7H4N2O3
Formula Weight
164.12
MOL File
3272-08-0.mol
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4-Hydroxy-3-nitrobenzonitrile Property

Melting point:
146-148 °C (lit.)
Boiling point:
291.56°C (rough estimate)
Density 
1.5018 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
Sealed in dry,Room Temperature
pka
4.66±0.14(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C7H4N2O3/c8-4-5-1-2-7(10)6(3-5)9(11)12/h1-3,10H
InChIKey
INBLGVOPOSGVTA-UHFFFAOYSA-N
SMILES
C(#N)C1=CC=C(O)C([N+]([O-])=O)=C1
CAS DataBase Reference
3272-08-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39-36/37/39-24/25
WGK Germany 
3
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
344575
Product name
4-Hydroxy-3-nitrobenzonitrile
Purity
98%
Packaging
25g
Price
$356
Updated
2025/07/31
TRC
Product number
H950868
Product name
4-Hydroxy-3-nitrobenzonitrile
Packaging
1g
Price
$75
Updated
2021/12/16
ChemScene
Product number
CS-W008477
Product name
4-Hydroxy-3-nitrobenzonitrile
Purity
99.53%
Packaging
100g
Price
$159
Updated
2021/12/16
Matrix Scientific
Product number
087916
Product name
4-Hydroxy-3-nitrobenzonitrile
Packaging
10g
Price
$171
Updated
2021/12/16
SynQuest Laboratories
Product number
4655-1-0C
Product name
4-Hydroxy-3-nitrobenzonitrile
Packaging
5G
Price
$104
Updated
2021/12/16
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4-Hydroxy-3-nitrobenzonitrile Chemical Properties,Usage,Production

Chemical Properties

yellow powder

Uses

4-Hydroxy-3-nitrobenzonitrile may be used in the synthesis of:

  • 3-azido-4-methoxybenzonitrile
  • 4-methoxy-3-nitrobenzonitrile
  • ethyl [2,2-dimethyl-6-(Δ2-thiazolin-2-yl)-4H-l,4-benzoxazin-3-one-4-yl]butyrate

General Description

4-Hydroxy-3-nitrobenzonitrile is one of the main photoproduct formed during hotolytic destruction of herbicide bromoxynil.

Synthesis

3011-34-5

3272-08-0

General procedure for the synthesis of 4-hydroxy-3-nitrobenzonitrile from 4-hydroxy-3-nitrobenzaldehyde: Aromatic aldehyde 1 (0.500 mmol, 1.0 eq.) and trimethylsilyl azide (TMSN3; 115 mg, 1.00 mmol, 2.0 eq.) were dissolved in a pre-mixed solvent mixture of hexafluoroisopropanol (HFIP) and acetonitrile (ACN) (2.0 mL, 1:1 volume ratio) in two dram vials, which was carried out under nitrogen protection. Subsequently, trifluoromethanesulfonic acid (TfOH; 17.7 μL, 0.200 mmol, 0.40 eq.) was added to the reaction system, and exothermic and rapid foaming phenomena due to gas production were immediately observed. The vial was quickly capped and the reaction mixture was stirred at room temperature for 20 to 75 min. Upon completion of the reaction, the reaction mixture was concentrated under a stream of nitrogen. The residue obtained was suspended in a solvent mixture of dichloromethane (CH2Cl2) and hexane and this suspension was upsampled into a cartridge containing 5 g silica gel. Purification was carried out by normal-phase silica gel fast column chromatography using a CombiFlash purification system, and suitable fractions were collected and concentrated to give the target product, aromatic nitrile 2.

References

[1] Journal of Organic Chemistry, 2012, vol. 77, # 12, p. 5364 - 5370
[2] Molecules, 2016, vol. 21, # 1,
[3] Patent: US5614520, 1997, A

4-Hydroxy-3-nitrobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxy-3-nitrobenzonitrile Suppliers

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View Lastest Price from 4-Hydroxy-3-nitrobenzonitrile manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
4-Hydroxy-3-nitrobenzonitrile 3272-08-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KGS
Release date
2025-11-20
Henan Fengda Chemical Co., Ltd
Product
4-Hydroxy-3-nitrobenzonitrile 3272-08-0
Price
US $100.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-25
Career Henan Chemical Co
Product
4-Hydroxy-3-nitrobenzonitrile 3272-08-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-01-29

3272-08-0, 4-Hydroxy-3-nitrobenzonitrileRelated Search:

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