EMBELIN
- Product Name
- EMBELIN
- CAS No.
- 550-24-3
- Chemical Name
- EMBELIN
- Synonyms
- EMBELIN;emberine;NSC 91874;Embelin-RM;embelicacid;Embelin, >98%;XIAP INHIBITOR;EMbeliaquinone;TIMTEC-BB SBB005949;Embelin (Embelic acid)
- CBNumber
- CB7365074
- Molecular Formula
- C17H26O4
- Formula Weight
- 294.39
- MOL File
- 550-24-3.mol
EMBELIN Property
- Melting point:
- 142-143°C
- Boiling point:
- 356.15°C (rough estimate)
- Density
- 1.131
- refractive index
- 1.4230 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: >10 mg/mL
- form
- solid
- pka
- 2.84±0.50(Predicted)
- color
- Dark orange
- Sensitive
- Light Sensitive
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
- LogP
- 5.024 (est)
Safety
- WGK Germany
- 3
- RTECS
- DK4230000
N-Bromosuccinimide Price
- Product number
- E1406
- Product name
- Embelin
- Purity
- ≥98% (HPLC), powder
- Packaging
- 10mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 178493
- Product name
- Apoptosis Activator III, Embelin
- Packaging
- 10mg
- Price
- $146
- Updated
- 2024/03/01
- Product number
- J64074
- Product name
- Embelin
- Packaging
- 10mg
- Price
- $91.65
- Updated
- 2024/03/01
- Product number
- J64074
- Product name
- Embelin
- Packaging
- 50mg
- Price
- $303.65
- Updated
- 2024/03/01
- Product number
- 11838
- Product name
- Embelin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $68
- Updated
- 2024/03/01
EMBELIN Chemical Properties,Usage,Production
Description
Embelin (550-24-3) inhibits?the lysine acetyl transferase PCAF?in vitro and in vivo?(in vitro?IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged.1? Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 μM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells.3?Possesses anti-inflammatory and analgesic activity?in vivo.4?Cell-permeable.
Chemical Properties
Orange Solid
Uses
Embelin is a natural benzoquinone found in plants of the Myrsinaceae family. Embelin has a wide range of biological activity as it inhibits the growth of bacteria, fungi, protozoa and parasites. Embelin also displays contraceptive and pro-apoptotic properties.
Definition
ChEBI: A member of the class of dihydroxy-1,4-benzoquinones that is 2,5-dihydroxy-1,4-benzoquinone which is substituted by an undecyl group at position 3. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antimicrobial, an ineoplastic and inhibitory activity towards hepatitis C protease.
Biological Activity
Cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC 50 = 4.1 μ M in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC 50 4-6 μ M), but has a weaker effect on normal prostate cells (IC 50 = 19-20 μ M). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo .
References
1) Modak?et al. (2013),?Probing p300/CBP associated factor (PCAF)-dependent pathways with a small molecule inhibitor; ACS Chem. Biol.,?8?1311 2) Nikolovska-Coleska?et al. (2004),?Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database; J. Med. Chem.,?47?2430 3) Shah?et al.?(2016),?Embelin inhibits proliferation, induces apoptosis and alters gene expression profiles in breast cancer cells; Pharmacol. Rep.,?68?638 4) Chitra?et al. (1994),?Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.; Chemotherapy,?40?109
EMBELIN Preparation Products And Raw materials
Raw materials
Preparation Products
EMBELIN Suppliers
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View Lastest Price from EMBELIN manufacturers
- Product
- Embelin 550-24-3
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-04-26
- Product
- 2,5-Cyclohexadiene-1,4-dione,2,5-dihydroxy-3-undecyl- 550-24-3
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09