2-IMINOTHIOLANE

Product Name: 2-IMINOTHIOLANE
CAS No.: 4781-83-3
Chemical Name: 2-IMINOTHIOLANE
Synonyms: 2-IMINOTHIOLANE HYDROCHLORIDE;TRAUT'S REAGENT;Nsc340007;2-Iminothiolane ,98%;dihydrothiophen-2(3H)-iMine;thiolan-2-iMine;2-IMINOTHIOLANE;Traut’s Reagent;Traut''s Reagent;2-IMINOTHIOLANE HCL
CBNumber: CB7373482
Molecular Formula: C4H7NS.ClH
Formula Weight: 137.63
MOL File: 4781-83-3.mol

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2-IMINOTHIOLANE Property

Melting point:: 198-201 °C(lit.)
storage temp.: 2-8°C
solubility: H₂O: 100 mg/mL
form: powder
color: White to Off-White
Water Solubility: Freely soluble in water
BRN: 3620079
CAS DataBase Reference: 4781-83-3(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 1-3-10
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I6256
Product name: 2-Iminothiolane hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 100mg
Price: $68.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: I6256
Product name: 2-Iminothiolane hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 1g
Price: $212.8
Updated: 2024/03/01

Alfa Aesar

Product number: J60131
Product name: 2-Iminothiolane hydrochloride
Packaging: 250mg
Price: $178
Updated: 2024/03/01

Alfa Aesar

Product number: J60131
Product name: 2-Iminothiolane hydrochloride
Packaging: 1g
Price: $267
Updated: 2024/03/01

Sigma-Aldrich

Product number: I6256
Product name: 2-Iminothiolane hydrochloride
Purity: ≥98% (TLC), powder
Packaging: 500mg
Price: $256
Updated: 2024/03/01

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2-IMINOTHIOLANE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

Cross-linking reagent cleavable by thiols.

Uses

2-Iminothiolane hydrochloride is predominantly used as an amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides. It is also used as a RNA-protein crosslinking reagent as well as useful in cross-linking proteins..

Uses

2-Iminothiolane hydrochloride is a valuable tool in studies of cellular organelles and oligomeric enzymes, using the techniques of protein-protein cross-linking. It may also be used to introduce reactive sulfhydryl groups into proteins for subsequent reaction with alkylating agents or heavy metal compounds.

General Description

2-Iminothiolane hydrochloride (2-IT.HCl), a protein modification reagent, is commonly employed to attach thiol groups to proteins and peptides. Raman spectroscopic analysis of hair keratin fibers modified with 2-IT.HCl showed the formation of new disulfide groups.

Purification Methods

Recrystallise the hydrochloride from MeOH/Et2O (m 187-192o) or (MeOH/Me2CO), but after sublimation at ~180o/0.2mm the melting point rises to 202-203o. It has 1HNMR with 2.27 (2H, t), 3.25 (2H, t) and 3.52 (2H, t) in (CD3)2SO. [King et al. Biochemistry 17 1499 1978.] The free base is purifed by vacuum distillation (b 71-72o/6mm) with IR (film) with 1700 (C=N)cm-1 and 1HNMR (CDCl3) with at 3.58 (2H, t) and max 2.10-2.8 (4H, m). The free base is stable on storage but slowly hydrolyses in aqueous solutions with half-lives at 25o of 390hours at pH 9.1, 210hours at pH 10 and 18hours at pH 11. [Traut et al. Biochemistry 12 3266 1973, Biochemistry 17 399 1978, Alagon & King Biochemistry 19 4343 1980, Beilstein 17/9 V 12.]

2-IMINOTHIOLANE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-IMINOTHIOLANE Suppliers

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View Lastest Price from 2-IMINOTHIOLANE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Iminothiolane hydrochloride 4781-83-3
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-18

4781-83-3, 2-IMINOTHIOLANERelated Search:

N-Hydroxysulfosuccinimide sodium salt N-Succinimidyl S-Acetylthioglycolate 2-IMINOTHIOLANE HYDROCHLORIDE (TRAUT'S REAGENT) 5-methyl-2-iminothiolane 6 ASP PEPTIDE WITH TRAUT'S REAGENT (2-IMINOTHIOLANE) 2-IMINOTHIOLANE

Nsc340007

2-Iminothiolane ,98%

2-Iminothiolane hydrochloride,2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Traut’s reagent

thiolan-2-iMine

dihydrothiophen-2(3H)-iMine

2(3H)-ThiopheniMine,dihydro-, hydrochloride (1:1)

2-Iminothiolane hydrochloride >=98% (TLC), powder

IMinothiolane hydrochlorid

thiolan-2-imine hydrochloride

Traut's reagent,2-Iminothiolane hydrochloride

Dihydrothiophen-2(3H)-imine hydrochloride

2-Iminothiolane hydrochloride≥ 98% (HPLC)

TRAUT'S REAGENT

2-THIOLANIMINE HYDROCHLORIDE

2-IMINOTHIOLANE

2-IMINOTHIOLANE HCL

2-IMINOTHIOLANE HYDROCHLORIDE

METHYL 4-MERCAPTOBUTYRIMIDATE HYDROCHLORIDE

DIHYDRO-2(3H)-THIOPHENIMINE HYDROCHLORIDE

Methyl-4-mercaptobutyrimidate hydrochloride 2-Iminothiolane hydrochloride

2(3H)-Thiophenimine, dihydro-, hydrochloride

2-Thiolanimine hydrochloride, 2IT, Dihydro-2(3H)-thiophenimine hydrochloride, Trauts reagent

2-Furancarboxyaldehyde, Reagent

2(3H)-Thiophenimine, dihydro-, dihydrochloride

2-Aminothiolidine hydrochloride

Traut''s reagent, RNA-protein crosslinking (sulfhydryl addition) agent

Traut’s Reagent

Traut''s Reagent

2-Iminothiolane HCl, 10 mM in DMSO

4781-83-3

C4H7N1S1

C4H7NSHCl

C4H8ClNS

BioChemical

Reagents for lysine modification

Protein Modification

Proteomics and Protein Expression

Proteomics

Specific Amino Acid Modification

Protein Modification Reagents

MTS and Sulfhydryl Active Reagents

MTS & Sulfhydryl Active Reagents

Sulfur & Selenium Compounds