ChemicalBook > CAS DataBase List > 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE

1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE

Product Name
1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
CAS No.
780753-89-1
Chemical Name
1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
Synonyms
1-(4-Fluorophenyl)-2-piperazinone;2-Piperazinone, 1-(4-fluorophenyl)-;1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
CBNumber
CB7374924
Molecular Formula
C10H11FN2O
Formula Weight
194.21
MOL File
780753-89-1.mol
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1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Property

Boiling point:
414.0±40.0 °C(Predicted)
Density 
1.225
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
7.52±0.20(Predicted)
InChI
InChI=1S/C10H11FN2O/c11-8-1-3-9(4-2-8)13-6-5-12-7-10(13)14/h1-4,12H,5-7H2
InChIKey
CRJMGHCZJHTTKV-UHFFFAOYSA-N
SMILES
N1(C2=CC=C(F)C=C2)CCNCC1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0062780
Product name
1-(4-FLUOROPHENYL)PIPERAZIN-2-ONE
Purity
95.00%
Packaging
5MG
Price
$498.78
Updated
2021/12/16
AK Scientific
Product number
2234AC
Product name
1-(4-Fluorophenyl)piperazin-2-one
Packaging
250mg
Price
$251
Updated
2021/12/16
Chemenu
Product number
CM128873
Product name
1-(4-fluorophenyl)piperazin-2-one
Purity
95%
Packaging
1g
Price
$351
Updated
2021/12/16
Crysdot
Product number
CD11057802
Product name
1-(4-Fluorophenyl)piperazin-2-one
Purity
95+%
Packaging
1g
Price
$367
Updated
2021/12/16
Chemenu
Product number
CM128873
Product name
1-(4-fluorophenyl)piperazin-2-one
Purity
95%
Packaging
5g
Price
$959
Updated
2021/12/16
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1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Chemical Properties,Usage,Production

Synthesis

1284243-44-2

780753-89-1

General procedure for the synthesis of 1-(4-fluorophenyl)-2-piperazinone from tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate: To a solution of 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylic acid tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate (2 g, 6.80 mmol) in methylene chloride (5 ml), was slowly added a solution of 1,4-dioxane with hydrogen chloride (16.99 ml. 68.0 mmol). The reaction mixture was stirred at 0°C and subsequently warmed up to 25°C and continued stirring for 3 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure to give the crude product salt. The crude product was ground with ether (2 x 10 ml), decanted and dried to give 1-(4-fluorophenyl)piperazin-2-one hydrochloride (1.2 g, 5.20 mmol, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 9.9 (broad single peak, 1H, D2O exchangeable), 7.38-7.34 (multiple peaks, 4H), 3.85-3.72 (multiple peaks, 4H), 3.55-3.50 (multiple peaks, 2H). Mass spectrometry analysis showed m/z 195 (M+1).

References

[1] Patent: WO2014/9872, 2014, A1. Location in patent: Page/Page column 64

1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Suppliers

China 25 India 1 United States 6 Global 32
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
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China
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4903
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Changzhou Hopschain Chemical Co.,Ltd.
Tel
85528066 13775048983
Fax
0519-85528066
Email
sales@hopschem.com
Country
China
ProdList
31553
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55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58
Aikon International Limited
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025-66061636 19370895928
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15813
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58
Suzhou Nuoouman Biological Technology Co., Ltd.
Tel
15026866316
Email
180642609@qq.com
Country
China
ProdList
4968
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58
Chengdu Saint - Kay Biotechnology Co., Ltd.
Tel
028-85157043 15882256948
Email
676046971@qq.com
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China
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4188
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58
Shanghai Jizhi Biochemical Technology Co. Ltd.
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021-4009004166/18616739031 18616739031
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3007523370@qq.com
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China
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52678
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Cool Pharm, Ltd
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021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
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China
ProdList
10000
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58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30227
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58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49977
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58

780753-89-1, 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONERelated Search:

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  • 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
  • 1-(4-Fluorophenyl)-2-piperazinone
  • 2-Piperazinone, 1-(4-fluorophenyl)-
  • 780753-89-1