1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
- Product Name
- 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
- CAS No.
- 780753-89-1
- Chemical Name
- 1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
- Synonyms
- 1-(4-Fluorophenyl)-2-piperazinone;2-Piperazinone, 1-(4-fluorophenyl)-;1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE
- CBNumber
- CB7374924
- Molecular Formula
- C10H11FN2O
- Formula Weight
- 194.21
- MOL File
- 780753-89-1.mol
1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Property
- Boiling point:
- 414.0±40.0 °C(Predicted)
- Density
- 1.225
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.52±0.20(Predicted)
- InChI
- InChI=1S/C10H11FN2O/c11-8-1-3-9(4-2-8)13-6-5-12-7-10(13)14/h1-4,12H,5-7H2
- InChIKey
- CRJMGHCZJHTTKV-UHFFFAOYSA-N
- SMILES
- N1(C2=CC=C(F)C=C2)CCNCC1=O
N-Bromosuccinimide Price
- Product number
- HCH0062780
- Product name
- 1-(4-FLUOROPHENYL)PIPERAZIN-2-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.78
- Updated
- 2021/12/16
- Product number
- 2234AC
- Product name
- 1-(4-Fluorophenyl)piperazin-2-one
- Packaging
- 250mg
- Price
- $251
- Updated
- 2021/12/16
- Product number
- CM128873
- Product name
- 1-(4-fluorophenyl)piperazin-2-one
- Purity
- 95%
- Packaging
- 1g
- Price
- $351
- Updated
- 2021/12/16
- Product number
- CD11057802
- Product name
- 1-(4-Fluorophenyl)piperazin-2-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $367
- Updated
- 2021/12/16
- Product number
- CM128873
- Product name
- 1-(4-fluorophenyl)piperazin-2-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $959
- Updated
- 2021/12/16
1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Chemical Properties,Usage,Production
Synthesis
1284243-44-2
780753-89-1
General procedure for the synthesis of 1-(4-fluorophenyl)-2-piperazinone from tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate: To a solution of 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylic acid tert-butyl 4-(4-fluorophenyl)-3-oxopiperazine-1-carboxylate (2 g, 6.80 mmol) in methylene chloride (5 ml), was slowly added a solution of 1,4-dioxane with hydrogen chloride (16.99 ml. 68.0 mmol). The reaction mixture was stirred at 0°C and subsequently warmed up to 25°C and continued stirring for 3 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure to give the crude product salt. The crude product was ground with ether (2 x 10 ml), decanted and dried to give 1-(4-fluorophenyl)piperazin-2-one hydrochloride (1.2 g, 5.20 mmol, 77% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 9.9 (broad single peak, 1H, D2O exchangeable), 7.38-7.34 (multiple peaks, 4H), 3.85-3.72 (multiple peaks, 4H), 3.55-3.50 (multiple peaks, 2H). Mass spectrometry analysis showed m/z 195 (M+1).
References
[1] Patent: WO2014/9872, 2014, A1. Location in patent: Page/Page column 64
1-(4-FLUORO-PHENYL)-PIPERAZIN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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