6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester

Uses

Product Name: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester
CAS No.: 485799-04-0
Chemical Name: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester
Synonyms: 2-MORPHOLIN-5-PYRIDYLBORONIC ACID PINACOL ESTER;6-MORPHOLINOPYRIDINE-3-BORONIC ACID, PINACOL EST;6-MORPHOLINOPYRIDIN-3-YLBORONIC ACID PINACOL ESTER;6-MORPHOLINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-MORPHOLINOPYRIDINE-5-BORONIC ACID, PINACOL ESTER;4-Morpholino-2-pyridine-5-boronic acid pinacol ester;2-(4-MORPHOLINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER;6-(4-MORPHOLINO)PYRIDINE-3-BORONIC ACID PINACOL ESTER;6-(4-Morpholinyl)pyridine-3-boronic acid pinacol ester;6-(MORPHOLIN-4-YL)PYRIDINE-3-BORONIC ACID PINACOL ESTER
CBNumber: CB7375002
Molecular Formula: C15H23BN2O3
Formula Weight: 290.17
MOL File: 485799-04-0.mol

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6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester Property

Melting point:: 135-139 °C (lit.)
Boiling point:: 440.9±45.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 5.58±0.10(Predicted)
Appearance: White to off-white Solid
CAS DataBase Reference: 485799-04-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 22-24/25-45-43A-36/37/39-26
RIDADR: 2811
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 654310
Product name: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $94
Updated: 2023/06/20

Sigma-Aldrich

Product number: 654310
Product name: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester
Purity: 97%
Packaging: 5g
Price: $262
Updated: 2023/01/07

TRC

Product number: T889575
Product name: 4-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine
Packaging: 10mg
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 281837
Product name: 4-Morpholino-2-pyridine-5-boronic acid pinacol ester
Packaging: 5g
Price: $805
Updated: 2021/12/16

ChemScene

Product number: CS-W003923
Product name: 4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)morpholine
Purity: ≥98.0%
Packaging: 25g
Price: $339
Updated: 2021/12/16

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6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester Chemical Properties,Usage,Production

Uses

6-(morpholino-4-yl)pyridine-3-boronic acid pinacol ester, also known as 6-(4-morpholino)pyridine-3-boronic acid pinacol ester, is an important pharmaceutical and chemical intermediate.

Synthesis

73183-34-3

200064-11-5

485799-04-0

Pinacol ester of bisboronic acid (1.25 g, 4.92 mmol) was dissolved in DMF (10 mL) under nitrogen protection and cooled to 0 °C. KOAc (1.21 g, 12.3 mmol) and Pd(dppf)Cl2-CH2Cl2 (0.1 g, 0.123 mmol) were added sequentially. The reaction mixture was heated to 80 °C and a solution of 5-bromo-2-morpholine pyridine (1.0 g, 4.1 mmol) in DMF (10 mL) was added dropwise. After the dropwise addition, the reaction was continued to be stirred at 80 °C for 10 hours. After completion of the reaction, the solvent was removed by evaporation. The residue was dissolved in ethyl acetate and the insoluble material was removed by filtration. The filtrate was evaporated and purified by column chromatography (eluent ratio: ethyl acetate:petroleum ether = 1:4) to afford 6-(morpholin-4-yl)pyridine-3-boronic acid pinacol ester (940 mg, 79% yield).

References

[1] Patent: WO2008/88881, 2008, A1. Location in patent: Page/Page column 41-42
[2] Patent: WO2009/155527, 2009, A2. Location in patent: Page/Page column 136

6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester Suppliers

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View Lastest Price from 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester manufacturers

Dideu Industries Group Limited

Product: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester 485799-04-0
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester 485799-04-0
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-08

485799-04-0, 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol esterRelated Search:

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2-MORPHOLINOPYRIDINE-5-BORONIC ACID, PINACOL ESTER

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4-Morpholino-2-pyridine-5-boronic acid pinacol ester

4-[5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]Morpholine

4-[5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]morpholine, 2-(Morpholin-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester 97%

6-MORPHOLINOPYRIDINE-3-BORONIC ACID, PINACOL EST

Morpholine, 4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-

6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester ISO 9001：2015 REACH

6-(4-Morpholinyl)pyridine-3-boronic acid pinacol ester(contains varying amounts of Anhydride)

485799-04-0

C15H23BN2O3

Heteroaryl

Organometallic Reagents

Boronate Esters

Boronic Acids and Derivatives

Boric Acid| Boric Acid Ester| Potassium Trifluoroborate

Amino

Organoborons

Pyridine