ChemicalBook > CAS DataBase List > (4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE

(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE

Product Name
(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE
CAS No.
40507-78-6
Chemical Name
(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE
Synonyms
indanazolin;INDANAZOLINE;4-Indanyl-AI;2-(4-IndanaMino)-2-iMidazoline;(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE;N-(2,3-Dihydro-1H-inden-4-yl)-4,5-dihydro-1H-imidazol-2-amine;1H-Imidazol-2-amine, N-(2,3-dihydro-1H-inden-4-yl)-4,5-dihydro-
CBNumber
CB7389957
Molecular Formula
C12H15N3
Formula Weight
201.27
MOL File
40507-78-6.mol
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(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE Property

Melting point:
109-113°
Boiling point:
329.2±52.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
9.01±0.10(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
I499800
Product name
Indanazoline
Packaging
250mg
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010563
Product name
(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE
Purity
95.00%
Packaging
250MG
Price
$1963.5
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0010563
Product name
(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE
Purity
95.00%
Packaging
25MG
Price
$329.7
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
59148
Product name
Indanazoline
Packaging
25mg
Price
$650
Updated
2021/12/16
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(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE Chemical Properties,Usage,Production

Originator

Farial,Nordmark-Werke,W. Germany,1980

Uses

Indanazoline is a sympathomimetic imidazoline derivative. Cyclopentamine showed vasoconstrictive action after local or intravenous applications.

Definition

ChEBI: Indanazoline is a member of indanes.

Manufacturing Process

38.5 g (0.1 mol) of N-4-indanyl thiourea are dissolved in 250 cc of methanol. 42,6 g (0.3 mol) of methyl iodide are added thereto and the mixture is refluxed for 2,5 hours. The mixture thereafter is cooled and the solvent is removed in a rotation evaporator in a vacuum. Thus, 57.5 g of N-4-indanyl-S_x0002_methylisothiuronium hydroiodide (86% of theoretical) are obtained. Melting point 144°C to 146°C.
33.49 (0.1 mol) of N-4-indanyl-S-methylisothiuronium hydroiodide are mixed with 9.0 g (0.15 mol) of anhydrous ethylenediamine. The mixture is slowly heated to 80°C and heating is continued until the termination of the formation of methylmercaptan (about 4 hours). After cooling the residue is dissolved in 2N hydrochloric acid and the solution is extracted with chloroform. The extract is discarded and the aqueous phase is rendered alkaline by the addition of 10% soda lye. The resulting solution is extracted with chloroform and the extract is washed with water, dried over anhydrous sodium sulfate and the solvent is removed. An oily residue is obtained which upon standing soon crystallizes.
The product is recrystallized from petroleum ether having a boiling range of 100°C to 140°C in the presence of activated carbon. Thus, 11.1 g of 2-(4- indanylamino)-2-imidazoline (55% of theoretical) are obtained as the free base. Melting point 109°C to 113°C.

Therapeutic Function

Nasal decongestant

(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE Suppliers

Loba Feinchemie AG
Tel
--
Fax
--
Email
sales@loba.co.at
Country
Austria
ProdList
900
Advantage
61

40507-78-6, (4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINERelated Search:


  • INDANAZOLINE
  • (4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-4-INDANYLAMINE
  • indanazolin
  • N-(2,3-Dihydro-1H-inden-4-yl)-4,5-dihydro-1H-imidazol-2-amine
  • 2-(4-IndanaMino)-2-iMidazoline
  • 1H-Imidazol-2-amine, N-(2,3-dihydro-1H-inden-4-yl)-4,5-dihydro-
  • 4-Indanyl-AI
  • 40507-78-6