(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one

Product Name: (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
CAS No.: 486443-73-6
Chemical Name: (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one
Synonyms: LC3-mHTT-IN-AN1;LC3-mHTT-IN-AN1 (Compound AN1);LC3-mHTT-IN-AN1, 10 mM in DMSO;5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one;(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one;2H-Indol-2-one, 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-;Autophagosome-tethering compounds,LC3mHTTINAN1,Autophagy,LC3 mHTT IN AN1,ATTECs,Inhibitor,LC-3-mHTT-IN-AN1,inhibit
CBNumber: CB73915407
Molecular Formula: C15H9Br2NO3
Formula Weight: 411.04
MOL File: 486443-73-6.mol

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(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Property

storage temp.: 2-8°C
solubility: DMSO: 125 mg/mL (304.11 mM)
form: A solid
color: Light yellow to yellow
Water Solubility: Water: < 0.1 mg/mL (insoluble)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed

Product number: A1193421
Product name: 5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity: 96%
Packaging: 5mg
Price: $72
Updated: 2021/12/16

Ambeed

Product number: A1193421
Product name: 5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity: 96%
Packaging: 10mg
Price: $94
Updated: 2021/12/16

Ambeed

Product number: A1193421
Product name: 5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity: 96%
Packaging: 50mg
Price: $159
Updated: 2021/12/16

CSNpharm

Product number: CSN25321
Product name: LC3-mHTT-IN-AN1
Packaging: 1mg
Price: $201
Updated: 2021/12/16

Ambeed

Product number: A1193421
Product name: 5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one
Purity: 96%
Packaging: 100mg
Price: $254
Updated: 2021/12/16

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(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Chemical Properties,Usage,Production

Biological Activity

AN1 is a brain blood barrier penetrant agent th at tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears th at AN1 interact with the polyQ stretch.

(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one Suppliers

China 37 United States 5 Global 42

InvivoChem

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486443-73-6, (3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-oneRelated Search:

(3Z)-5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-1H-indol-2-one

LC3-mHTT-IN-AN1

2H-Indol-2-one, 5-bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-

LC3-mHTT-IN-AN1 (Compound AN1)

5-Bromo-3-(3-bromo-4,5-dihydroxybenzylidene)indolin-2-one

Autophagosome-tethering compounds,LC3mHTTINAN1,Autophagy,LC3 mHTT IN AN1,ATTECs,Inhibitor,LC-3-mHTT-IN-AN1,inhibit

LC3-mHTT-IN-AN1, 10 mM in DMSO

486443-73-6