ChemicalBook > CAS DataBase List > (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine

(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine

Product Name
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
CAS No.
662164-09-2
Chemical Name
(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
Synonyms
D3-βArr;D3-βArr;C 00379308;D3- beta Arr;NCGC00379308;D3-βArr?- NCg;D3-βArr- NCGC 00379308;D3-βArr, 10 mM in DMSO;D3-βArr?- NCGC 00379308;NCGC00379308 (D3-βArr )
CBNumber
CB73919157
Molecular Formula
C20H23N5
Formula Weight
333.43
MOL File
662164-09-2.mol
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(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Property

storage temp. 
Store at -20°C
solubility 
DMSO: ≥ 125 mg/mL (374.89 mM)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2256
Product name
D3-βArr
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$84.83
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2256
Product name
D3-βArr
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$287
Updated
2025/07/31
ChemScene
Product number
CS-0088722
Product name
D3-βArr
Purity
99.48%
Packaging
50mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0088722
Product name
D3-βArr
Purity
99.48%
Packaging
10mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-0088722
Product name
D3-βArr
Purity
99.48%
Packaging
5mg
Price
$70
Updated
2021/12/16
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(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Chemical Properties,Usage,Production

Uses

D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].

Biological Activity

D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling th at initiates translocation of β-Arr 1 by direct TSHR activation, while showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation.

References

[1] Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. DOI:10.1124/jpet.117.244095

(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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(1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine Suppliers

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662164-09-2, (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amineRelated Search:

Chlorotrimethylsilane p-Anisidine 2-Methylfuran Hydroxyethyl piperazine N-Methyldiethanolamine

  • (1-Phenyl-ethyl)-(2-piperazin-1-yl-quinazolin-4-yl)-amine
  • D3- beta Arr
  • D3-βArr
  • D3-βArr?- NCGC 00379308
  • NCGC00379308
  • C 00379308
  • D3-βArr?- NCg
  • 4-Quinazolinamine, N-(1-phenylethyl)-2-(1-piperazinyl)-
  • D3-βArr- NCGC 00379308
  • D3-betaArr >=98% (HPLC)
  • NCGC00379308 (D3-βArr )
  • Thyroid-stimulating hormone Receptor,D3-βArr,Thyrotropin receptor,inhibit,D3βArr,TSH Receptor,Inhibitor,D-3-βArr,D3 βArr
  • N-(1-Phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine
  • D3-βArr?- NC C 00379308
  • D3-βArr, 10 mM in DMSO
  • D3-βArr
  • 662164-09-2