3,3'-Diindolylmethane

Product Name: 3,3'-Diindolylmethane
CAS No.: 1968-05-4
Chemical Name: 3,3'-Diindolylmethane
Synonyms: 68-05-4;HB 236;ARUNDINE;Plant Indole;Indole dimer;Diindole methane;Di(1H-indol-3-yl);DI INDOLYL METHANE;DI-3-INDOLYLMETHANE;3-DIINDOLYL METHANE
CBNumber: CB7396111
Molecular Formula: C17H14N2
Formula Weight: 246.31
MOL File: 1968-05-4.mol

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3,3'-Diindolylmethane Property

Melting point:: 167 °C
Boiling point:: 230 °C(Press: 0.01 Torr)
Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 16.91±0.30(Predicted)
form: Off-white powder.
color: White to Pale Beige
InChI: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
InChIKey: VFTRKSBEFQDZKX-UHFFFAOYSA-N
SMILES: C(C1C2=C(NC=1)C=CC=C2)C1C2=C(NC=1)C=CC=C2
LogP: 4.401 (est)
CAS DataBase Reference: 1968-05-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-26
WGK Germany: 3
RTECS: NM0332000
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D9568
Product name: 3,3′-Diindolylmethane
Purity: ≥98% (HPLC)
Packaging: 5G
Price: $181
Updated: 2023/06/20

Sigma-Aldrich

Product number: 74601
Product name: 3,3′-Diindolylmethane
Purity: analytical standard
Packaging: 100MG
Price: $175
Updated: 2022/05/15

TCI Chemical

Product number: M1399
Product name: 3,3'-Methylenediindole
Purity: >98.0%(N)
Packaging: 5g
Price: $60
Updated: 2024/03/01

TCI Chemical

Product number: M1399
Product name: 3,3'-Methylenediindole
Purity: >98.0%(N)
Packaging: 25g
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 15927
Product name: 3,3'-Diindolylmethane
Purity: ≥98%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

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3,3'-Diindolylmethane Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

apoptosis inducer

Uses

An antineoplastic agent that activates Chk 2 and cytochrome p450

Uses

3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.

Definition

ChEBI: 3,3'-diindolylmethane is a member of indoles. It has a role as an antineoplastic agent and a P450 inhibitor.

General Description

3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.

Biological Activity

3,3'-diindolylmethane is an anticancer agent [1].3,3'-diindolylmethane (dim) is a dimer of indole-3-carbinol generated in low ph environment. it inhibited cell growth with ic50 values of 17, 24 and 30 μm in mcf-7, t47d and saos2 cell lines, respectively. dim induced apoptosis in these cells without affecting the p53 pathway. in human nasopharyngeal carcinoma (npc) cell line (5-8f npc), treatment of dim decreased the ability of cell migration and invasion dose-dependently. in rats, transplanted with npc cells, dim administration resulted in suppressing lymph node metastasis. besides that, dim was found to induce erα target gene expression and the concomitant cell proliferation at low concentration (10μm) in the absence of e2 [1, 2 and 3].

Biochem/physiol Actions

Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

References

1. ge x, yannai s, rennert g, et al. 3, 3′-diindolylmethane induces apoptosis in human cancer cells. biochemical and biophysical research communications, 1996, 228(1): 153-158. 2. wu t, chen c, li f, et al. 3, 3' diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. experimental and therapeutic medicine, 2014, 7(6): 1635-1638. 3. marques m, laflamme l, benassou i, et al. low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. bmc cancer, 2014, 14(1): 524.

3,3'-Diindolylmethane Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3'-Diindolylmethane Suppliers

Americas 1 China 385 Czech 1 Europe 3 Germany 3 India 15 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 17 United States 47 Global 480

Shengbaolai Biotechnology Co., Ltd

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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Chembest Research Laboratories Limited

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TCI (Shanghai) Development Co., Ltd.

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Capot Chemical Co., Ltd

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Beijing Ouhe Technology Co., Ltd

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Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
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View Lastest Price from 3,3'-Diindolylmethane manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3,3'-Diindolylmethane 1968-05-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-07

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3, 3-Diindolylmethane 1968-05-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-23

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 3,3'-Diindolylmethane 1968-05-4
Price: US $100.00-75.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-20

1968-05-4, 3,3'-Diindolylmethane Related Search:

Dibromomethane DIETHOXYMETHANE Diiodomethane Diphenylmethane 4,4'-Methylenedianiline Dibenzoylmethane 1H-INDOL-3-OL 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-METHOXYPHENOL 3,3'-Diindolylmethane AURORA 23218 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-ETHOXYPHENOL 3,3'-((4-METHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE) 1-(2,4-DICHLOROBENZYL)-3-(1-[1-(2,4-DICHLOROBENZYL)-1H-INDOL-3-YL]VINYL)-1H-INDOLE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-(1-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-INDOL-3-YL)VINYL)-1H-INDOLE 2-[2,2-BIS-(1H-INDOL-3-YL)-ETHYL]-PHENYLAMINE 4-(2-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-4,6-DICHLOROPHENYL)MORPHOLINE 1'-ACETYL-1H,1'H-3,3':3',3'-TERINDOL-2'(1'H)-ONE 3,3'-((3,4-DIMETHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE)

3,3'-Diindolylmethane(DIM)

Di(1H-indol-3-yl)

Plant Indole

3,3'-DIINDOLYLMETHANE, >=98% (HPLC)

3,3'-METHYLENEBIS-1H-INDOLE

3,3'-METHYLENEBISINDOLE

3,3'-METHYLENEDIINDOLE

3,3'-DIINDOLYLMETHANE

ARUNDINE

BIS(3-INDOLYL)METHANE

DI-INDOYLMETHANE, 3,3'-

DI INDOLYL METHANE

DI-3-INDOLYLMETHANE

2-carboxy-5-nitrobenzne sulfonic acid

DIINDOLYLMETHANE(DIM)

3-DIINDOLYL METHANE

Indolyl-CH2-Indolyl

3,3-DI-INDOLY-METHANE

Indole dimer

Diindole methane

3,3’-Diindolylmethane 3,3'-Methylenebisindole

Di(1H-indol-3-yl)Methane

DI-INDOLYLMETHANE, 3,3'-(RG)

1H-Indole,3,3'-Methylenebis-

3,3'-DiindolylMethane, 98%, 98%

3,3'-BisindolylMethane

Bis(1H-indol-3-yl)Methane 3,3'-Methylenediindole

HB 236

3,3'-Diindolymetane

DI-INDOYLMETHANE, 3,3'-(P)

68-05-4

3,3'-Methylenediindole&gt

3,3'-Diindolylmethane / diindolylmethane

3,3'-Diindolylmethane ISO 9001：2015 REACH

1968-05-4 3,3'-Diindolylmethane

3,3'-Diindolylmethane 99%min

DIINDOLYLMETHANE, 3,3'-

3,3'-Diindolylmethane

Diindolylmethane DIM / 3,3'-Diindolylmethane

HB 236|||DIM|||Arundine

3,3''-Diindolylmethane

(DIM) Diindolylmethane

3,3'-Diindolylmethane 99%min

3,3'-Methylenebisindole

3,3''-Diindolylmethane (DIM), antitumor agent

1968-05-4

196-85-4

1968-5-4

1968-05-04

68-05-4

1968-05-1

1968-05-2

968-05-4

C17H14N2

Indoles

Simple Indoles

Inhibitors

Pharmaceutical intermediates