3,3'-Diindolylmethane

Product Name: 3,3'-Diindolylmethane
CAS No.: 1968-05-4
Chemical Name: 3,3'-Diindolylmethane
Synonyms: DIM;68-05-4;HB 236;ARUNDINE;Plant Indole;Indole dimer;Diindole methane;Di(1H-indol-3-yl);DI INDOLYL METHANE;DI-3-INDOLYLMETHANE
CBNumber: CB7396111
Molecular Formula: C17H14N2
Formula Weight: 246.31
MOL File: 1968-05-4.mol

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3,3'-Diindolylmethane Property

Melting point:: 167 °C
Boiling point:: 230 °C(Press: 0.01 Torr)
Density: 1.271±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
pka: 16.91±0.30(Predicted)
form: Off-white powder.
color: White to Pale Beige
InChI: InChI=1S/C17H14N2/c1-3-7-16-14(5-1)12(10-18-16)9-13-11-19-17-8-4-2-6-15(13)17/h1-8,10-11,18-19H,9H2
InChIKey: VFTRKSBEFQDZKX-UHFFFAOYSA-N
SMILES: C(C1C2=C(NC=1)C=CC=C2)C1C2=C(NC=1)C=CC=C2
LogP: 4.401 (est)
CAS DataBase Reference: 1968-05-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-26
WGK Germany: 3
RTECS: NM0332000
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D9568
Product name: 3,3′-Diindolylmethane
Purity: ≥98% (HPLC)
Packaging: 5G
Price: $181
Updated: 2023/06/20

Sigma-Aldrich

Product number: 74601
Product name: 3,3′-Diindolylmethane
Purity: analytical standard
Packaging: 100MG
Price: $175
Updated: 2022/05/15

TCI Chemical

Product number: M1399
Product name: 3,3'-Methylenediindole
Purity: >98.0%(N)
Packaging: 5g
Price: $60
Updated: 2024/03/01

TCI Chemical

Product number: M1399
Product name: 3,3'-Methylenediindole
Purity: >98.0%(N)
Packaging: 25g
Price: $182
Updated: 2024/03/01

Cayman Chemical

Product number: 15927
Product name: 3,3'-Diindolylmethane
Purity: ≥98%
Packaging: 100mg
Price: $32
Updated: 2024/03/01

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3,3'-Diindolylmethane Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

apoptosis inducer

Uses

An antineoplastic agent that activates Chk 2 and cytochrome p450

Uses

3,3′-Diindolylmethane may be used as a model substrate to analyze the role of 3,3′-diindolylmethane in inducing apoptosis in human cancer cells.

Definition

ChEBI: 3,3'-diindolylmethane is a member of indoles. It has a role as an antineoplastic agent and a P450 inhibitor.

General Description

3,3′-Diindolylmethane, a dimer of indole-3-carbinol, is a component of cruciferous vegetables. It is known to exhibit anticancer effects.

Biological Activity

3,3'-diindolylmethane is an anticancer agent [1].3,3'-diindolylmethane (dim) is a dimer of indole-3-carbinol generated in low ph environment. it inhibited cell growth with ic50 values of 17, 24 and 30 μm in mcf-7, t47d and saos2 cell lines, respectively. dim induced apoptosis in these cells without affecting the p53 pathway. in human nasopharyngeal carcinoma (npc) cell line (5-8f npc), treatment of dim decreased the ability of cell migration and invasion dose-dependently. in rats, transplanted with npc cells, dim administration resulted in suppressing lymph node metastasis. besides that, dim was found to induce erα target gene expression and the concomitant cell proliferation at low concentration (10μm) in the absence of e2 [1, 2 and 3].

Biochem/physiol Actions

Acid-catalyzed reaction product of a phytochemical naturally found in Brassicaceae, indole-3-carbinol. It functions as an antitumor agent. This derivative can both directly stimulate apoptosis at relatively high concentrations and sensitize TRAIL-induced apoptosis in human cancer cells. DIM induces a G1 cell cycle arrest in human breast cancer MCF-7 cells by a mechanism that includes increased expression of p21. DIM is a strong mitochondrial H+-ATPase inhibitor. The function of DIM and its derivatives as a new plant growth promoter has been studied in an eco-friendly system.

References

1. ge x, yannai s, rennert g, et al. 3, 3′-diindolylmethane induces apoptosis in human cancer cells. biochemical and biophysical research communications, 1996, 228(1): 153-158. 2. wu t, chen c, li f, et al. 3, 3' diindolylmethane inhibits the invasion and metastasis of nasopharyngeal carcinoma cells in vitro and in vivo by regulation of epithelial mesenchymal transition. experimental and therapeutic medicine, 2014, 7(6): 1635-1638. 3. marques m, laflamme l, benassou i, et al. low levels of 3, 3 [prime]-diindolylmethane activate estrogen receptor alpha and induce proliferation of breast cancer cells in the absence of estradiol. bmc cancer, 2014, 14(1): 524.

3,3'-Diindolylmethane Preparation Products And Raw materials

Raw materials

Preparation Products

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3,3'-Diindolylmethane Suppliers

Americas 1 China 372 Czech 1 Europe 3 Germany 3 India 15 Japan 3 Slovakia 1 South Korea 1 Switzerland 2 Ukraine 1 United Kingdom 17 United States 44 Global 464

Xi`an Tian Guangyuan Biotech Co., Ltd.

Tel: 17391926474
Email: 2539013658@qq.com
Country: China
ProdList: 206
Advantage: 58

HUBEI ZHENBO CHEM CO,LTD

Tel: 18086513998
Email: hubeizhenbochem@163.com
Country: China
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J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
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Chembest Research Laboratories Limited

Tel: 021-20908456
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Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18217
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-82967028 13552068683
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12426
Advantage: 60

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

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View Lastest Price from 3,3'-Diindolylmethane manufacturers

airuikechemical co., ltd.

Product: 3,3′-diindolylmethane 1968-05-4
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: 3,3'-Diindolylmethane 1968-05-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-03-29

PNP Biotech Co. Ltd

Product: 3,3'-Diindolylmethane 1968-05-4
Price: US $0.00/KG
Min. Order: 25KG
Purity: 99%HPLC
Supply Ability: Inquiry
Release date: 2022-09-19

1968-05-4, 3,3'-Diindolylmethane Related Search:

Dibromomethane DIETHOXYMETHANE Diiodomethane Diphenylmethane 4,4'-Methylenedianiline Dibenzoylmethane 1H-INDOL-3-OL 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-METHOXYPHENOL 3,3'-Diindolylmethane AURORA 23218 4-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-2-ETHOXYPHENOL 3,3'-((4-METHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE) 1-(2,4-DICHLOROBENZYL)-3-(1-[1-(2,4-DICHLOROBENZYL)-1H-INDOL-3-YL]VINYL)-1H-INDOLE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3-(1-(1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-1H-INDOL-3-YL)VINYL)-1H-INDOLE 2-[2,2-BIS-(1H-INDOL-3-YL)-ETHYL]-PHENYLAMINE 4-(2-(BIS(2-METHYL-1H-INDOL-3-YL)METHYL)-4,6-DICHLOROPHENYL)MORPHOLINE 1'-ACETYL-1H,1'H-3,3':3',3'-TERINDOL-2'(1'H)-ONE 3,3'-((3,4-DIMETHOXYPHENYL)METHYLENE)BIS(2-P-TOLYL-1H-INDOLE)

3,3'-Diindolylmethane(DIM)

Di(1H-indol-3-yl)

Plant Indole

3,3'-DIINDOLYLMETHANE, >=98% (HPLC)

3,3'-METHYLENEBIS-1H-INDOLE

3,3'-METHYLENEBISINDOLE

3,3'-METHYLENEDIINDOLE

3,3'-DIINDOLYLMETHANE

ARUNDINE

BIS(3-INDOLYL)METHANE

DIM

DI-INDOYLMETHANE, 3,3'-

DI INDOLYL METHANE

DI-3-INDOLYLMETHANE

2-carboxy-5-nitrobenzne sulfonic acid

DIINDOLYLMETHANE(DIM)

3-DIINDOLYL METHANE

Indolyl-CH2-Indolyl

3,3-DI-INDOLY-METHANE

Indole dimer

Diindole methane

3,3’-Diindolylmethane 3,3'-Methylenebisindole

Di(1H-indol-3-yl)Methane

DI-INDOLYLMETHANE, 3,3'-(RG)

1H-Indole,3,3'-Methylenebis-

3,3'-DiindolylMethane, 98%, 98%

3,3'-BisindolylMethane

Bis(1H-indol-3-yl)Methane 3,3'-Methylenediindole

HB 236

3,3'-Diindolymetane

DI-INDOYLMETHANE, 3,3'-(P)

68-05-4

3,3'-Methylenediindole&gt

3,3'-Diindolylmethane / diindolylmethane

3,3'-Diindolylmethane ISO 9001：2015 REACH

1968-05-4 3,3'-Diindolylmethane

3,3'-Diindolylmethane 99%min

DIINDOLYLMETHANE, 3,3'-

3,3'-Diindolylmethane

1968-05-4

196-85-4

1968-5-4

1968-05-04

68-05-4

1968-05-1

1968-05-2

968-05-4

C17H14N2

Indoles

Simple Indoles

Inhibitors

Pharmaceutical intermediates

Gene Regulation

Gene Regulation and Expression

Alkaloid

Antitumor Agents

Aromatic Compounds

Building Blocks