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Dibenzoylmethane

Product Name
Dibenzoylmethane
CAS No.
120-46-7
Chemical Name
Dibenzoylmethane
Synonyms
DBM;1,3-diphenylpropane-1,3-dione;1,3-DIPHENYL-1,3-PROPANEDIONE;karenzudk2;phenylphenacylketone;Phenyl phenacyl ketone;1,3-Diphenylpropanedione;1,3-diphenyl-3-propanedione;dppd-h;arenzu dk 2
CBNumber
CB7175433
Molecular Formula
C15H12O2
Formula Weight
224.25
MOL File
120-46-7.mol
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Dibenzoylmethane Property

Melting point:
77-79 °C(lit.)
Boiling point:
219-221 °C18 mm Hg(lit.)
Density 
0.800 g/cm3
vapor pressure 
0.01Pa at 20℃
refractive index 
1.6600 (estimate)
Flash point:
219-221°C/18mm
storage temp. 
Store below +30°C.
solubility 
Chloroform (Slightly), Methanol (Slightly, Sonicated)
pka
8.95±0.10(Predicted)
form 
Crystals
color 
Light yellow to yellow
Water Solubility 
It is Soluble in ether, chloroform, and aqueous sodium hydroxide. Insoluble in water.
Merck 
14,3009
BRN 
514910
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
NZZIMKJIVMHWJC-UHFFFAOYSA-N
LogP
4.59 at 25℃
CAS DataBase Reference
120-46-7(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanedione, 1,3-diphenyl-(120-46-7)
EPA Substance Registry System
1,3-Propanedione, 1,3-diphenyl- (120-46-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
TZ1930000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29143900
Toxicity
rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 28, 1953.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D33454
Product name
1,3-Diphenyl-1,3-propanedione
Purity
98%
Packaging
25g
Price
$54.6
Updated
2024/03/01
Sigma-Aldrich
Product number
D33454
Product name
1,3-Diphenyl-1,3-propanedione
Purity
98%
Packaging
100g
Price
$201
Updated
2024/03/01
TCI Chemical
Product number
D0910
Product name
1,3-Diphenyl-1,3-propanedione
Purity
>98.0%(GC)
Packaging
25g
Price
$20
Updated
2024/03/01
TCI Chemical
Product number
D0910
Product name
1,3-Diphenyl-1,3-propanedione
Purity
>98.0%(GC)
Packaging
100g
Price
$38
Updated
2024/03/01
Alfa Aesar
Product number
A13450
Product name
1,3-Diphenyl-1,3-propanedione, 98+%
Packaging
25g
Price
$51.6
Updated
2024/03/01
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Dibenzoylmethane Chemical Properties,Usage,Production

Chemical Properties

Dibenzoylmethane (DB), a minor constituent of the root extract of licorice, belongs to the flavonoid family. It is a colorless rhombus flake crystal or yellowish-white powder. soluble in chlorohydrin and chloroform, soluble in sodium hydroxide solution, insoluble in sodium carbonate solution, and very slightly soluble in water. It is used as a colorimetric reagent for the determination of uranium.

Occurrence

Dibenzoylmethane(DBM) is a 1,3-diketone derivative of acetylacetone that has both methyl groups replaced with phenyl groups.Although smaller in size and lacking hydroxyl and methoxy groups,DBM resembles the turmeric spice curcumin (CUR),a diferuloylmethane. Both molecules are metal-chelating agents,contain a B-diketone flanked by two aryl groups,and exhibit anti-proliferative and anticarcinogenic activity. In addition to sharing structural similarity with DBM,CUR,which is also a naturally occurring compound is found in the plant Curcuma longa and has numerous medicinal uses.
DBM and its many naturally occurring derivatives are minor constituentsof licorice. DBM has been isolated from licorice root extracts and otherspecies of Glycyrrhiza.

Uses

Dibenzoylmethane is a new kind of PVC heat stabilizer, it has better transparency, nontoxic and odorless. In case of combined use with Calcium/Zinc, Barium/Zin and other heat stabilizer, it can greatly improve the initial color, transparency, long term stability of PVC, and also can improve the precipitation and “zinc burning” problem during the process. It has very good synergy with zinc soaps, and can protect the PVC color. This material can absorb UV at 290nm, which has the effect as light stabilizer and act as long term stabilizer for PVC products.

Uses

Dibenzoylmethane is a compound known to inhibit tumorigenesis in mice.

Definition

ChEBI: Dibenzoylmethane is a beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects. It has a role as an antineoplastic agent, a metabolite and an antimutagen. It is a beta-diketone and an aromatic ketone.

Preparation

dibenzoylmethane is prepared by condensation of ethyl benzoate with acetophenone.

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 3885, 1996 DOI: 10.1016/0040-4039(96)00689-2
Chemical and Pharmaceutical Bulletin, 29, p. 2762, 1981 DOI: 10.1248/cpb.29.2762

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits acrid smoke and irritating vapors

Purification Methods

Dibenzoylmethane (1,3-diphenyl-1,3-propanedione) [120-46-7] M 224.3, m 8 0o. Crystallise dibenzoylmethane from pet ether or MeOH. [Beilstein 7 IV 2512.]

Dibenzoylmethane Preparation Products And Raw materials

Raw materials

Preparation Products

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Dibenzoylmethane Suppliers

Wuhan beileye Biomedical Technology Co., Ltd
Tel
18086118076; 18086118076
Email
1784708432@qq.com
Country
China
ProdList
4207
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Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com
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China
ProdList
613
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60
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
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66
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
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84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
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Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
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View Lastest Price from Dibenzoylmethane manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dibenzoylmethane 120-46-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-14
Baoji Guokang Bio-Technology Co., Ltd.
Product
Dibenzoylmethane 120-46-7
Price
US $9680.00/T
Min. Order
1T
Purity
98%
Supply Ability
1-250mt
Release date
2021-06-09
Hebei Weibang Biotechnology Co., Ltd
Product
Dibenzoylmethane 120-46-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30

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