4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
- Product Name
- 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
- CAS No.
- 39143-25-4
- Chemical Name
- 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID
- Synonyms
- 4-Amino-1-benzyl-4-carboxypiperidine;4-Amino-1-benzylpiperidine-4-carboxylic;N'-(3,4-dichlorophenyl)propane-1,6-diamine;1-Benzyl-4-amino-4-piperidinecarboxylic acid;4-AMINO-1-BENZYL-4-PIPERIDINECARBOXYLIC ACID;4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID;4-Amino-1-(phenylmethyl)-4-piperidinecarboxylic acid;4-Piperidinecarboxylic acid, 4-aMino-1-(phenylMethyl)-
- CBNumber
- CB7407620
- Molecular Formula
- C13H18N2O2
- Formula Weight
- 234.29
- MOL File
- 39143-25-4.mol
4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Property
- Melting point:
- 247-248°
- Boiling point:
- 385.7±42.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.73±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C13H18N2O2/c14-13(12(16)17)6-8-15(9-7-13)10-11-4-2-1-3-5-11/h1-5H,6-10,14H2,(H,16,17)
- InChIKey
- UAPJXCZSNCQLMR-UHFFFAOYSA-N
- SMILES
- N1(CC2=CC=CC=C2)CCC(N)(C(O)=O)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A593955
- Product name
- 4-Amino-1-benzyl-piperidine-4-carboxylicacid
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FA147476
- Product name
- 4-Amino-1-benzyl-piperidine-4-carboxylicacid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- CS-W006436
- Product name
- 4-Amino-1-benzylpiperidine-4-carboxylicacid
- Purity
- >98.0%
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR480328
- Product name
- 4-Amino-1-benzyl-piperidine-4-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $76
- Updated
- 2021/12/16
- Product number
- FA147476
- Product name
- 4-Amino-1-benzyl-piperidine-4-carboxylicacid
- Packaging
- 1g
- Price
- $208
- Updated
- 2021/12/16
4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
28936-94-9
39143-25-4
The general procedure for the synthesis of 1-benzyl-4-amino-4-piperidinecarboxylic acid using 8-benzyl-2,4-dioxo-1,3,8-triazaspiro[4,5]decane as a starting material was as follows: 2.4 kg of sodium hydroxide was dissolved in 10 L of deionized water in a 20 L reactor. Subsequently, 614 g of 8-benzyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (1.38) was added to this solution to form a reaction suspension. The suspension was heated to 80°C. After reaching 80°C, the temperature was gradually increased at a rate of 10°C per step. When the temperature was raised to 105°C, the reaction mixture began to foam vigorously. The reaction was maintained at 108°C with continuous stirring overnight. Upon completion of the reaction, the mixture was cooled to 10 °C, and 5 L of concentrated hydrochloric acid was slowly added dropwise to adjust the pH to 7-8. During the dropwise addition, the reaction temperature was controlled to be no more than 23 °C. A solid was precipitated from the reaction solution and the precipitate was collected by filtration. The resulting solid was dried under vacuum at 40 °C for 3 days, followed by drying at 80 °C overnight to give 469.7 g of 1-benzyl-4-amino-4-piperidinecarboxylic acid (I.39) in a final yield of 85% of the theoretical value.
References
[1] Patent: WO2012/101013, 2012, A1. Location in patent: Page/Page column 97; 98
[2] Patent: US2013/23502, 2013, A1. Location in patent: Paragraph 0266; 0269-0270
[3] Journal of Medicinal Chemistry, 2002, vol. 45, # 18, p. 3972 - 3983
[4] Patent: WO2016/78771, 2016, A1. Location in patent: Page/Page column 134
4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID manufacturers
- Product
- 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID 39143-25-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24