4-TERT-BUTYLPHENYLACETIC ACID

Product Name: 4-TERT-BUTYLPHENYLACETIC ACID
CAS No.: 32857-63-9
Chemical Name: 4-TERT-BUTYLPHENYLACETIC ACID
Synonyms: BTS-10335;ASISCHEM Y85510;RARECHEM AL BO 0709;Butylphenylessigsureca;4-T-BUTYLPHENYLACETIC ACID;Phenylacetic acid tert-butyl;2-(4-tert-butylphenyl)acetate;4-TERT-BUTYLPHENYLACETIC ACID;p-tert-Butylphenylacetic acid;4-Tert-Butylbenzeneacetic Acid
CBNumber: CB7409336
Molecular Formula: C12H16O2
Formula Weight: 192.25
MOL File: 32857-63-9.mol

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4-TERT-BUTYLPHENYLACETIC ACID Property

Melting point:: 77-78°C
Boiling point:: 302.8±11.0 °C(Predicted)
Density: 1.047±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 4.41±0.10(Predicted)
color: White to Almost white
InChI: InChI=1S/C12H16O2/c1-12(2,3)10-6-4-9(5-7-10)8-11(13)14/h4-7H,8H2,1-3H3,(H,13,14)
InChIKey: RUAYXHSDAMWEDR-UHFFFAOYSA-N
SMILES: C1(CC(O)=O)=CC=C(C(C)(C)C)C=C1
CAS DataBase Reference: 32857-63-9(CAS DataBase Reference)
EPA Substance Registry System: Benzeneacetic acid, 4-(1,1-dimethylethyl)- (32857-63-9)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4307
Product name: 4-tert-Butylphenylacetic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $32
Updated: 2025/07/31

TCI Chemical

Product number: B4307
Product name: 4-tert-Butylphenylacetic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $108
Updated: 2025/07/31

TRC

Product number: B809655
Product name: 4-tert-Butylphenylacetic Acid
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK503262
Product name: 4-tert-Butylphenylacetic Acid
Purity: 98%
Packaging: 1g
Price: $81
Updated: 2021/12/16

Matrix Scientific

Product number: 034848
Product name: 4-tert-Butylphenylacetic acid
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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4-TERT-BUTYLPHENYLACETIC ACID Chemical Properties,Usage,Production

Chemical Properties

Almost white crystalline powder

Synthesis

3549-23-3

32857-63-9

The general procedure for the synthesis of 4-tert-butylphenylacetic acid from methyl 4-tert-butylphenylacetate was as follows: 4-tert-butylphenylacetic acid methyl ester (4.13 g, 20 mmol) was dissolved in methanol (160 mL), and water (40 mL) and sodium hydroxide (1.2 g, 30 mmol) were added sequentially. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the volatile solvent was removed by distillation under reduced pressure, and the residue was diluted with water and acidified with 1 N sulfuric acid solution to pH 4. The precipitated solid was filtered, washed with water, and dried to afford 4-tert-butylphenylacetic acid as a white solid in 39% yield. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and 13C NMR (101 MHz, CDCl3): 1H NMR δ 1.32 (s, 9H), 3.60 (s, 2H), 7.22 (d, J = 8.2 Hz, 2H), 7.35 (d, J = 8.2 Hz, 2H), 8.48 (s, 1H) ppm; 13C NMR δ 31.49 (3C), 34.62, 40.84, 125.70 (2C), 129.16 (2C), 130.57, 150.29, 177.92 ppm.

References

[1] Tetrahedron Asymmetry, 2016, vol. 27, # 19, p. 936 - 942
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 9, p. 2047 - 2050
[3] Journal of Medicinal Chemistry, 2000, vol. 43, # 23, p. 4354 - 4358
[4] Patent: WO2004/69792, 2004, A2. Location in patent: Page 125
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 9, p. 2386 - 2391

4-TERT-BUTYLPHENYLACETIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-TERT-BUTYLPHENYLACETIC ACID manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-TERT-BUTYLPHENYLACETIC ACID 32857-63-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2024-08-13

Career Henan Chemical Co

Product: 4-TERT-BUTYLPHENYLACETIC ACID 32857-63-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

32857-63-9, 4-TERT-BUTYLPHENYLACETIC ACIDRelated Search:

METHYL 4-TERT-BUTYLPHENYLACETATE, 97 4-tert-Butylbenzyl bromide 4'-tert-Butyl-4-chlorobutyrophenone 4-tert-Butylbenzyl chloride 4-TERT-BUTYLPHENYLACETIC ACID METHYL ESTER 4-TERT-BUTYLPHENYLACETIC ACID tert-Butylbenzene BTS ETHYL 4-TERT-BUTYLBENZOYLFORMATE AMINO(4-TERT-BUTYLPHENYL)ACETIC ACID 4-TERT-BUTYLCALIX(8)ARENE-OCTAACETIC ACID 2-(4-TERT-BUTYLPHENYL)-3,3,3-TRIFLUORO-2-HYDROXYPROPIONIC ACID (S)-2-HYDROXY-2-METHYL(4-TERT-BUTYLBENZENE)ACETIC ACID (R)-(4-TERT-BUTYL-PHENYL)-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)]-ACETIC ACID (S)-AMINO-(4-TERT-BUTYL-PHENYL)-ACETIC ACID (2R)-2-AMINO-2-[4-(TERT-BUTYL)PHENYL]PROPANOIC ACID (R)-2-HYDROXY-2-METHYL(4-TERT-BUTYLBENZENE)ACETIC ACID (S)-(4-TERT-BUTYL-PHENYL)-[(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)]-ACETIC ACID

4-(1,1-dimethylethyl)-benzeneaceticaci

RARECHEM AL BO 0709

4-T-BUTYLPHENYLACETIC ACID

4-TERT-BUTYLPHENYLACETIC ACID

BENZENEACETIC ACID, 4-(1,1-DIMETHYLETHYL)-

ASISCHEM Y85510

2-(4-tert-butylphenyl)acetate

4-Tert-Butylbenzeneacetic Acid

Butylphenylessigsureca

4-(t-Butyl)-phenylacetic acid , ca. 98%

ButylphenylaceticacidButylphenylaceticacid

4-tert-Butylphenylacetic acid 98%

BTS-10335

p-tert-Butylphenylacetic acid

4-tert-Butylphenylacetic acid,97%

Phenylacetic acid tert-butyl

4-<i>tert</i>-Butylphenylacetic Acid

4-tert-Butylphenylacetic Acid &gt

2-(4-tert-butylphenyl)aceticaci

4-(1,1-Dimethylethyl)benzeneacetic acid

32857-63-9

CARBOXYLIC ACID

Aromatic Phenylacetic Acids and Derivatives

pharmacetical