BTS
- Product Name
- BTS
- CAS No.
- 1576-37-0
- Chemical Name
- BTS
- Synonyms
- BTS;CLN3;Battenin;NSC 37123;N-Tosylbenzylamine;N-Benzyl-p-tosylaMide;LABOTEST-BB LT00786416;N-Tosylphenylmethanamine;N-Tosylbenzenemethaneamine;n-benzyl-p-toluenesulfonamid
- CBNumber
- CB9457528
- Molecular Formula
- C14H15NO2S
- Formula Weight
- 261.34
- MOL File
- 1576-37-0.mol
BTS Property
- Melting point:
- 115 °C
- Boiling point:
- 419.1±48.0 °C(Predicted)
- Density
- 1.204±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Dichloromethane, Ethyl Acetate (Slightly)
- pka
- 11.54±0.30(Predicted)
- form
- White crystalline solid
- color
- White to Off-White
- Sensitive
- Light Sensitive
- CAS DataBase Reference
- 1576-37-0(CAS DataBase Reference)
Safety
- RTECS
- XT5490000
- HS Code
- 2935.90.9500
- Toxicity
- rat,LD,oral,> 500mg/kg (500mg/kg),National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 41, 1953.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 203895
- Product name
- BTS
- Purity
- A potent inhibitor of Ca
- Packaging
- 5mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- B3082
- Product name
- N-Benzyl-p-toluenesulfonamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $131
- Updated
- 2024/03/01
- Product number
- B3082
- Product name
- N-Benzyl-p-toluenesulfonamide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $394
- Updated
- 2024/03/01
- Product number
- J64910
- Product name
- N-Benzyl-p-toluenesulfonamide
- Packaging
- 5mg
- Price
- $117.65
- Updated
- 2024/03/01
- Product number
- J64910
- Product name
- N-Benzyl-p-toluenesulfonamide
- Packaging
- 10mg
- Price
- $212
- Updated
- 2024/03/01
BTS Chemical Properties,Usage,Production
Description
BTS is an inhibitor of skeletal muscle myosin II ATPase activity that reduces the affinity of ADP-myosin for actin. It inhibits calcium-stimulated ATPase activity of rabbit muscle myosin subfragment 1 (S1) in an actin-independent manner with an IC50 value of approximately 5 μM. It is selective for calcium-stimulated myosin II over human platelet myosin II, kinesin, pyruvate kinase, and lactate dehydrogenase at 100 μM. BTS (2 μM) inhibits the activity of skeletal muscle myosin, reversibly reducing the sliding velocity of heavy meromyosin in a gliding-filament assay. It inhibits isometric calcium-activated tension in isolated fast-twitch rabbit psoas muscle fibers (IC50 = ~3 μM) but not in isolated slow-twitch rat trabeculae and papillary cardiac muscle. BTS is also an intermediate in the synthesis of sulfonamides.
Chemical Properties
White Solid
Uses
A potent inhibitor of skeletal muscle Ca2+-stimulated myosin S1 ATPase (IC50 approx. 5uM) activity. Reversible blocks the gliding motility. Also weakens myosin interaction with F-actin. Does not affect platelet myosin II
Uses
A potent inhibitor of calcium-stimulated myosin S1 ATPase
Definition
ChEBI: 4-methyl-N-(phenylmethyl)benzenesulfonamide is a sulfonamide.
Synthesis Reference(s)
The Journal of Organic Chemistry, 28, p. 592, 1963 DOI: 10.1021/jo01037a523
Biological Activity
Selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC 50 ~ 5 mM). Reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle.
storage
Desiccate at RT
BTS Preparation Products And Raw materials
Raw materials
Preparation Products
BTS Suppliers
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View Lastest Price from BTS manufacturers
- Product
- N-Benzyl-p-toluenesulfonaMide 1576-37-0
- Price
- US $10.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-12
- Product
- BTS 1576-37-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPCL
- Supply Ability
- 10t
- Release date
- 2019-12-20