1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
- Product Name
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
- CAS No.
- 84484-78-6
- Chemical Name
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
- Synonyms
- BTS 54-505;Sibutramine Impurity 1;BTS 54-505 hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HCL;N,N-Didesmethyl Sibutramine HCl;Didesmethyl Sibutramine Hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE;Sibutramine Hydrochloride Monohydrate Impurity G;Sibutramine Hydrochloride Monohydrate EP Impurity G;1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL
- CBNumber
- CB1145568
- Molecular Formula
- C15H23Cl2N
- Formula Weight
- 288.26
- MOL File
- 84484-78-6.mol
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Property
- Melting point:
- 160 - 166°C
- storage temp.
- Desiccate at RT
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 84484-78-6(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- 2322
- Product name
- BTS54-505hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $129
- Updated
- 2021/12/16
- Product number
- 2322
- Product name
- BTS54-505hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $524
- Updated
- 2021/12/16
- Product number
- D441170
- Product name
- DidesmethylSibutramineHydrochloride
- Packaging
- 5mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 163783
- Product name
- Didesmethyl Sibutramine Hydrochloride
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- BRS0000106
- Product name
- BTS 54-505
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $490
- Updated
- 2021/12/16
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Chemical Properties,Usage,Production
Biological Activity
Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis.
in vitro
simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1].
in vivo
the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2].
IC 50
0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake
References
[1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34.
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride manufacturers
- Product
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10t
- Release date
- 2019-12-24