1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

ChemicalBook > CAS DataBase List > 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

Product Name: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
CAS No.: 84484-78-6
Chemical Name: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
Synonyms: BTS 54-505;Sibutramine Impurity 1;BTS 54-505 hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HCL;N,N-Didesmethyl Sibutramine HCl;Didesmethyl Sibutramine Hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE;Sibutramine Hydrochloride Monohydrate Impurity G;Sibutramine Hydrochloride Monohydrate EP Impurity G;1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL
CBNumber: CB1145568
Molecular Formula: C15H23Cl2N
Formula Weight: 288.26
MOL File: 84484-78-6.mol

Less

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Property

Melting point:: 160 - 166°C
storage temp.: Desiccate at RT
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 84484-78-6(CAS DataBase Reference)

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Tocris

Product number: 2322
Product name: BTS54-505hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $129
Updated: 2021/12/16

Tocris

Product number: 2322
Product name: BTS54-505hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $524
Updated: 2021/12/16

TRC

Product number: D441170
Product name: DidesmethylSibutramineHydrochloride
Packaging: 5mg
Price: $100
Updated: 2021/12/16

Usbiological

Product number: 163783
Product name: Didesmethyl Sibutramine Hydrochloride
Packaging: 5mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000106
Product name: BTS 54-505
Purity: 95.00%
Packaging: 1G
Price: $490
Updated: 2021/12/16

Less

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Chemical Properties,Usage,Production

Biological Activity

Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis.

in vitro

simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1].

in vivo

the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2].

IC 50

0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake

References

[1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34.

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Suppliers

Canada 3 China 52 Germany 1 India 5 Slovakia 1 The Netherlands 1 United Kingdom 6 United States 20 Global 89

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Cato Research Chemicals Inc.

Tel: 020-81960175
Fax: +1-541-2553641
Email: min.he@cato-chem.com
Country: China
ProdList: 1958
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shenzhen SUNGENING Bio-Medical Co., Ltd.

Tel: 0755-28967200 13631290199
Fax: 0755-28967200
Email: wxf@sungening.com
Country: China
ProdList: 9506
Advantage: 60

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16028
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 2809
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55827
Advantage: 58

Guangzhou Dreampharm Biotechnology Co., Ltd.

Tel: 17825480238
Fax: QQ 3008233717
Email: 3008233717@qq.com
Country: China
ProdList: 9844
Advantage: 12

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28180
Advantage: 58

Jinan blalong chemical co. LTD

Tel: 2710913286@.com
Email: 1513643261@qq.com
Country: China
ProdList: 14253
Advantage: 58

Qi Qi hang Biotechnology Co., Ltd.

Tel: 13291169750 18151111370
Email: 1046215251@qq.com
Country: China
ProdList: 7988
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 15093356674;
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29826
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038; 18501792038
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9614
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-61856359 18690052321
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10010
Advantage: 58

Henan Weitesi Chemical Technology Co. LTD

Tel: 0371-0371-55135753 18003832934
Fax: QQ：2853979818
Email: 2853979818@qq.com
Country: China
ProdList: 10002
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8141
Advantage: 58

NORANA GROUP

Tel: 027-027-59209883 17386169806
Fax: 027-59209883
Email: service@nornachem.com
Country: China
ProdList: 4604
Advantage: 58

Guangzhou Juntang Technology Co., Ltd

Tel: 020-36607679 13502246435
Email: sales@dmstandards.com
Country: China
ProdList: 10951
Advantage: 58

Henan Lavoisier Chemical Products Co. Ltd

Tel: 0371-63682289 18625781376
Fax: 18625781376
Email: jacschem@163.com
Country: China
ProdList: 5009
Advantage: 58

Changzhou Furuisi Biotechnology Co., Ltd

Tel: 0519-85524369
Email: 3477467573@qq.com
Country: China
ProdList: 8618
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 31163
Advantage: 58

Hubei Yunmei Technology Co., Ltd

Tel: 027-59206672 18327059871
Email: service@yunmeichem.com
Country: China
ProdList: 5002
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18488
Advantage: 58

Bejing Famous Pharmaceutical Technology Co., Ltd.

Tel: 13331045123
Email: sales@peking-pharmacy.com
Country: China
ProdList: 9991
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9991
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 10002
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 11437
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4030
Advantage: 58

Shanghai Beiwanta Biotechnology Co., Ltd.

Tel: 021-67187366 19901745723
Email: info@bwtlab.com
Country: China
ProdList: 9241
Advantage: 58

ZhengZhou Edward Biology Co.,Ltd

Tel: 13298105281
Email: 893596907@qq.com
Country: China
ProdList: 7519
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 3674309880
Email: hanfangpharma@126.com
Country: China
ProdList: 30968
Advantage: 58

Aromsyn Co., Ltd.

Tel: +86-0571-85585865 +8613336024896
Email: CB@aromsyn.com
Country: China
ProdList: 19185
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Shanghai Yuda Industrial Co., Ltd.

Tel: --
Fax: --
Email: lucy@runwelltac.com
Country: CHINA
ProdList: 6107
Advantage: 58

Shanghai Haoyang Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 596799915@QQ.COM
Country: CHINA
ProdList: 2905
Advantage: 58

Beijing Bolide Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1985563437@qq.com
Country: CHINA
ProdList: 6172
Advantage: 58

Yancheng Lvye Chemical Co., Ltd

Tel: --
Fax: --
Email: ceo@lvyechem.com
Country: China
ProdList: 97
Advantage: 68

Shanghai Fortune Bio-Technology Co., Ltd.

Tel: --
Fax: --
Email: wangboquan1988@yahoo.com.cn
Country: China
ProdList: 124
Advantage: 50

Shanghai Chemsors Chemicals Co., Ltd.

Tel: --
Fax: --
Email: sales@chemsorschemicals.com
Country: China
ProdList: 105
Advantage: 50

Less

View Lastest Price from 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10t
Release date: 2019-12-24

84484-78-6, 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochlorideRelated Search:

Chlorodimethylphenylsilane Topotecan hydrochloride Silicone oil (high temperature) tert-Butyl methyl ether tert-Butyldimethylsilyl chloride N-Formyl N,N-Didesmethyl Sibutramine 2-(4-chlorophenyl)-N-ethyl-N,2,5-trimethylhexan -3-amine hydrochloride Desisobutyl-BenzylsibutraMine 4-Chlorobenzyl cyanide Sibutramine hydrochloride N-METHYLBUTYLAMINE BTS SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE (1-PHENYLCYCLOBUTYL)METHYLAMINE (+/-)-DIDESMETHYLSIBUTRAMINE N-MONODESMETHYL SIBUTRAMINE HCL [1-(4-chlorophenyl)cyclobutyl]methanamine 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

N-DI-DESMETHYL SIBUTRAMINE HCL

N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE

1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

Sibutramine Impurity 1

1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine,hydrochloride

N,N-Didesmethyl Sibutramine HCl

1-(4-CHLOROPHENYL)-BETA-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE HYDROCHLORIDE

BTS 54-505

1-(4-Chlorophenyl)-alpha-(2-Methylpropyl)Cyclobutane Methanamine Hydrochloride

1-[1-(4-Chlorophenyl)-alpha-(2-methylpropyl)cyclbutanemethan amine hydrochloride

Cyclobutamethamine,1-(4-chlorophenyl)-alpha-(2-methylpropyl)HCl

N-[1-(4-chlorophenyl)cyclobutyl-3-methylbutyl)]hydrochloride

Didesmethyl Sibutramine Hydrochloride

Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, ochloride

CYCLOBUTANEMETHANAMINE, 1-(4-CHLOROPHENYL)-A-(2-METHYLPROPYL)-, OCHLORIDE

Cyclobutanemethanamine, 1-(4-chlorophenyl)-alpha-(2-methylpropyl)-, hydrochloride

BTS 54-505 hydrochloride

Didesmethyl Sibutramine HydrochlorideQ: What is Didesmethyl Sibutramine Hydrochloride Q: What is the CAS Number of Didesmethyl Sibutramine Hydrochloride Q: What is the storage condition of Didesmethyl Sibutramine Hydrochloride

(1RS)-1-[1- (4-Chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Hydrochloride (N,N-Didesmethylsibutramine Hydro- chloride)

Sibutramine Hydrochloride Monohydrate EP Impurity G

Sibutramine Hydrochloride Monohydrate Impurity G

84484-78-6

C15H22ClNHCl

C15H22NClHCl

C15H23Cl2N