ChemicalBook > CAS DataBase List > 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

Product Name: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
CAS No.: 84484-78-6
Chemical Name: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
Synonyms: BTS 54-505;Sibutramine Impurity 1;Sibutramine Impurity 39;BTS 54-505 hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HCL;N,N-Didesmethyl Sibutramine HCl;Didesmethyl Sibutramine Hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE;Sibutramine Hydrochloride Monohydrate Impurity G;Sibutramine Hydrochloride Monohydrate EP Impurity G
CBNumber: CB1145568
Molecular Formula: C15H23Cl2N
Formula Weight: 288.26
MOL File: 84484-78-6.mol

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1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Property

Melting point:: 160 - 166°C
storage temp.: Desiccate at RT
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
CAS DataBase Reference: 84484-78-6(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2322
Product name: BTS54-505hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $129
Updated: 2021/12/16

Tocris

Product number: 2322
Product name: BTS54-505hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $524
Updated: 2021/12/16

TRC

Product number: D441170
Product name: DidesmethylSibutramineHydrochloride
Packaging: 5mg
Price: $100
Updated: 2021/12/16

Usbiological

Product number: 163783
Product name: Didesmethyl Sibutramine Hydrochloride
Packaging: 5mg
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BRS0000106
Product name: BTS 54-505
Purity: 95.00%
Packaging: 1G
Price: $490
Updated: 2021/12/16

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1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Chemical Properties,Usage,Production

Uses

Didesmethylsibutramine (BTS 54-505) hydrochloride is the primary amine metabolite of Sibutramine (antidepressant and anti-obesity agent). Didesmethylsibutramine hydrochloride inhibits NMDA-evoked activity. Didesmethylsibutramine hydrochloride is also a reuptake inhibitor. Didesmethylsibutramine hydrochloride induces thermogenesis[1][2].

Biological Activity

Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis.

in vitro

simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1].

in vivo

the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2].

IC 50

0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake

References

[1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34.

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%HPLC
Supply Ability: 10t
Release date: 2019-12-24

84484-78-6, 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochlorideRelated Search:

Chlorodimethylphenylsilane Topotecan hydrochloride Silicone oil (high temperature) tert-Butyl methyl ether tert-Butyldimethylsilyl chloride N-Formyl N,N-Didesmethyl Sibutramine 2-(4-chlorophenyl)-N-ethyl-N,2,5-trimethylhexan -3-amine hydrochloride Desisobutyl-BenzylsibutraMine 4-Chlorobenzyl cyanide Sibutramine hydrochloride N-METHYLBUTYLAMINE BTS SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE (1-PHENYLCYCLOBUTYL)METHYLAMINE (+/-)-DIDESMETHYLSIBUTRAMINE N-MONODESMETHYL SIBUTRAMINE HCL [1-(4-chlorophenyl)cyclobutyl]methanamine 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

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Didesmethyl Sibutramine HydrochlorideQ: What is Didesmethyl Sibutramine Hydrochloride Q: What is the CAS Number of Didesmethyl Sibutramine Hydrochloride Q: What is the storage condition of Didesmethyl Sibutramine Hydrochloride

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N,N-Didesmethylsibutramine Hydrochloride/BTS 54-505

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Sibutramine-N,N-bisdesmethyl hydrochloride 100 μg/mL in Acetonitrile

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84484-78-6

C15H22ClNHCl

C15H22NClHCl

C15H23Cl2N