ChemicalBook > CAS DataBase List > 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

Product Name
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
CAS No.
84484-78-6
Chemical Name
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
Synonyms
BTS 54-505;Sibutramine Impurity 1;BTS 54-505 hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HCL;N,N-Didesmethyl Sibutramine HCl;Didesmethyl Sibutramine Hydrochloride;N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE;Sibutramine Hydrochloride Monohydrate Impurity G;Sibutramine Hydrochloride Monohydrate EP Impurity G;1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL
CBNumber
CB1145568
Molecular Formula
C15H23Cl2N
Formula Weight
288.26
MOL File
84484-78-6.mol
More
Less

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Property

Melting point:
160 - 166°C
storage temp. 
Desiccate at RT
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
CAS DataBase Reference
84484-78-6(CAS DataBase Reference)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
2322
Product name
BTS54-505hydrochloride
Purity
≥99%(HPLC)
Packaging
10
Price
$129
Updated
2021/12/16
Tocris
Product number
2322
Product name
BTS54-505hydrochloride
Purity
≥99%(HPLC)
Packaging
50
Price
$524
Updated
2021/12/16
TRC
Product number
D441170
Product name
DidesmethylSibutramineHydrochloride
Packaging
5mg
Price
$100
Updated
2021/12/16
Usbiological
Product number
163783
Product name
Didesmethyl Sibutramine Hydrochloride
Packaging
5mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BRS0000106
Product name
BTS 54-505
Purity
95.00%
Packaging
1G
Price
$490
Updated
2021/12/16
More
Less

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Chemical Properties,Usage,Production

Biological Activity

Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis.

in vitro

simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1].

in vivo

the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2].

IC 50

0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake

References

[1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34.

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride Suppliers

Canada 3 China 57 Germany 1 India 5 Slovakia 1 The Netherlands 1 United Kingdom 6 United States 20 Global 94
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
More
Less

View Lastest Price from 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride 84484-78-6
Price
US $1.00/KG
Min. Order
1KG
Purity
98%HPLC
Supply Ability
10t
Release date
2019-12-24

84484-78-6, 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochlorideRelated Search:

Chlorodimethylphenylsilane Topotecan hydrochloride Silicone oil (high temperature) tert-Butyl methyl ether tert-Butyldimethylsilyl chloride N-Formyl N,N-Didesmethyl Sibutramine 2-(4-chlorophenyl)-N-ethyl-N,2,5-trimethylhexan -3-amine hydrochloride Desisobutyl-BenzylsibutraMine 4-Chlorobenzyl cyanide Sibutramine hydrochloride N-METHYLBUTYLAMINE BTS SIBUTRAMINE HYDROCHLORIDE MONOHYDRATE (1-PHENYLCYCLOBUTYL)METHYLAMINE (+/-)-DIDESMETHYLSIBUTRAMINE N-MONODESMETHYL SIBUTRAMINE HCL [1-(4-chlorophenyl)cyclobutyl]methanamine 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride

  • N-DI-DESMETHYL SIBUTRAMINE HCL
  • N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE
  • 1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL
  • 1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
  • Sibutramine Impurity 1
  • 1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutan-1-amine,hydrochloride
  • N,N-Didesmethyl Sibutramine HCl
  • 1-(4-CHLOROPHENYL)-BETA-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE HYDROCHLORIDE
  • BTS 54-505
  • 1-(4-Chlorophenyl)-alpha-(2-Methylpropyl)Cyclobutane Methanamine Hydrochloride
  • 1-[1-(4-Chlorophenyl)-alpha-(2-methylpropyl)cyclbutanemethan amine hydrochloride
  • Cyclobutamethamine,1-(4-chlorophenyl)-alpha-(2-methylpropyl)HCl
  • N-[1-(4-chlorophenyl)cyclobutyl-3-methylbutyl)]hydrochloride
  • Didesmethyl Sibutramine Hydrochloride
  • Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, ochloride
  • CYCLOBUTANEMETHANAMINE, 1-(4-CHLOROPHENYL)-A-(2-METHYLPROPYL)-, OCHLORIDE
  • Cyclobutanemethanamine, 1-(4-chlorophenyl)-alpha-(2-methylpropyl)-, hydrochloride
  • BTS 54-505 hydrochloride
  • Didesmethyl Sibutramine HydrochlorideQ: What is Didesmethyl Sibutramine Hydrochloride Q: What is the CAS Number of Didesmethyl Sibutramine Hydrochloride Q: What is the storage condition of Didesmethyl Sibutramine Hydrochloride
  • (1RS)-1-[1- (4-Chlorophenyl)cyclobutyl]-3-methylbutan-1-amine Hydrochloride (N,N-Didesmethylsibutramine Hydro- chloride)
  • Sibutramine Hydrochloride Monohydrate EP Impurity G
  • Sibutramine Hydrochloride Monohydrate Impurity G
  • 84484-78-6
  • C15H22ClNHCl
  • C15H22NClHCl
  • C15H23Cl2N