ChemicalBook > CAS DataBase List > ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate

ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate

Product Name
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
CAS No.
371924-24-2
Chemical Name
ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
Synonyms
MCU-i4 ，S9842;MCU-i4, 10 mM in DMSO;Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate;ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester;C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast
CBNumber
CB74119266
Molecular Formula
C23H27N3O2
Formula Weight
377.48
MOL File
371924-24-2.mol
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ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Property

Boiling point:
513.1±50.0 °C(Predicted)
Density 
1.163±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO:18.87(Max Conc. mg/mL);50.0(Max Conc. mM)
Ethanol:37.75(Max Conc. mg/mL);100.0(Max Conc. mM)
form 
Solid
pka
7.21±0.44(Predicted)
color 
White to yellow
InChI
InChI=1S/C23H27N3O2/c1-5-26(6-2)18-11-9-17(10-12-18)25-22-19-14-16(4)8-13-21(19)24-15-20(22)23(27)28-7-3/h8-15H,5-7H2,1-4H3,(H,24,25)
InChIKey
RIWXBJCWHVMATR-UHFFFAOYSA-N
SMILES
N1C2C(=CC(C)=CC=2)C(NC2=CC=C(N(CC)CC)C=C2)=C(C(OCC)=O)C=1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0159538
Product name
MCU-i4
Packaging
10mg
Price
$70
Updated
2021/12/16
ChemScene
Product number
CS-0159538
Product name
MCU-i4
Packaging
25mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0159538
Product name
MCU-i4
Packaging
50mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0159538
Product name
MCU-i4
Packaging
100mg
Price
$400
Updated
2021/12/16
Ambeed
Product number
A1445645
Product name
Ethyl4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
Purity
98+%
Packaging
100mg
Price
$366
Updated
2021/12/16
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ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Chemical Properties,Usage,Production

Uses

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2].

Biological Activity

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2]. MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts.

storage

Store at -20°C

References

[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.

ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Suppliers

China 34 Finland 1 Ukraine 1 United States 4 Global 40
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
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371924-24-2, ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylateRelated Search:


  • ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
  • Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
  • C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast
  • 3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester
  • MCU-i4, 10 mM in DMSO
  • MCU-i4 ，S9842
  • 371924-24-2