ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate

Product Name: ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
CAS No.: 371924-24-2
Chemical Name: ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate
Synonyms: Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate;ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate;3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester;C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast
CBNumber: CB74119266
Molecular Formula: C23H27N3O2
Formula Weight: 377.48
MOL File: 371924-24-2.mol

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ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Property

Boiling point:: 513.1±50.0 °C(Predicted)
Density: 1.163±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO:18.87(Max Conc. mg/mL);50.0(Max Conc. mM)
Ethanol:37.75(Max Conc. mg/mL);100.0(Max Conc. mM)
pka: 7.21±0.44(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0159538
Product name: MCU-i4
Packaging: 10mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-0159538
Product name: MCU-i4
Packaging: 25mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0159538
Product name: MCU-i4
Packaging: 50mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0159538
Product name: MCU-i4
Packaging: 100mg
Price: $400
Updated: 2021/12/16

Ambeed

Product number: A1445645
Product name: Ethyl4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate
Purity: 98+%
Packaging: 250mg
Price: $549
Updated: 2021/12/16

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ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Chemical Properties,Usage,Production

Biological Activity

MCU-i4 blocks the IP3-dependent mitochondrial Ca2+-uptake, maintaining the gatekeeping role of their target[1][2]. MCU-i4 modulates mitochondrial Ca2+ uptake to 1 min of incubation, i.e., exerting a negative modulation, indicating that the primary effect of these compounds is a sudden and direct modulation of MCU complex activity[1].MCU-i4 exerted a negative effect on δψ. MCU-i4 has no effect on cell viability[1]. Cell Differentiation Assay[1] Cell Line: Growing medium of 90% confluent C2C12 myoblasts.

storage

Store at -20°C

References

[1]. Giulia Di Marco, et al. A High-Throughput Screening Identifies MICU1 Targeting Compounds. Cell Rep. 2020 Feb 18;30(7):2321-2331.e6. [2]. Alessandro Rimessi, et al. Update on Calcium Signaling in Cystic Fibrosis Lung Disease. Front Pharmacol. 2021 Mar 11;12:581645.

ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate Suppliers

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371924-24-2, ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylateRelated Search:

ethyl 4-((4-(diethylamino)phenyl)imino)-6-methyl-1,4-dihydroquinoline-3-carboxylate

Ethyl 4-((4-(diethylamino)phenyl)amino)-6-methylquinoline-3-carboxylate

C2C12,Inhibitor,mitochondrial,MCU-i-4,Mitochondrial Metabolism,MCU-i4,MCUi4,Ca2+,uptake,inhibit,MCU i4,myoblast

3-Quinolinecarboxylic acid, 4-[[4-(diethylamino)phenyl]amino]-6-methyl-, ethyl ester

371924-24-2