Description References
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Tamibarotene

Description References
Product Name
Tamibarotene
CAS No.
94497-51-5
Chemical Name
Tamibarotene
Synonyms
AM80;C12864;Amnoid;CS-1151;Amnolake;NSC 608000;amibarotene;Tamibarotene;UNII-08V52GZ;Retinoid AM 80
CBNumber
CB7426841
Molecular Formula
C22H25NO3
Formula Weight
351.44
MOL File
94497-51-5.mol
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Tamibarotene Property

Melting point:
231-232°C
Boiling point:
449.6±45.0 °C(Predicted)
Density 
1.154±0.06 g/cm3(Predicted)
RTECS 
DH6940000
storage temp. 
room temp
solubility 
Soluble to 50 mM in DMSO
pka
3.83±0.10(Predicted)
form 
powder
color 
white to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T3205
Product name
Tamibarotene
Purity
≥98% (HPLC)
Packaging
5mg
Price
$101
Updated
2024/03/01
Sigma-Aldrich
Product number
T3205
Product name
Tamibarotene
Purity
≥98% (HPLC)
Packaging
25mg
Price
$393
Updated
2024/03/01
Alfa Aesar
Product number
J64028
Product name
Tamibarotene
Packaging
10mg
Price
$157.65
Updated
2024/03/01
Alfa Aesar
Product number
J64028
Product name
Tamibarotene
Packaging
50mg
Price
$517.65
Updated
2024/03/01
Cayman Chemical
Product number
71770
Product name
AM80
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
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Tamibarotene Chemical Properties,Usage,Production

Description

Tamibarotene (brand name: Amnolake) is a kind of orally administrated synthetic retinoid. It is used to overcome the all- trans retinoid acid (ATRA) resistance, having potential antineoplastic activity against the acute promyelocytic leukaemia (APL). It can also be used for the treatment of Alzheimer's disease, multiple myeloma and Crohn's disease. Tamibarotene takes effect through directly acting as the specific agonist for retinoid acid receptor alpha/beta, and potentially binding to the retinoid X receptors (RXR). Compared to the ATRA, Tamibarotene is chemically more stable and much more potent as an inducer of differentiation and apoptosis in promyelocytic leukemia cells.

References

https://en.wikipedia.org/wiki/Tamibarotene
https://www.drugbank.ca/drugs/DB04942

Description

AM80 is a retinoic acid receptor agonist that is selective for RARα (Kd = 62 nM; AC50 = 1.46 nM) compared to RARβ (Kd = 280 nM; AC50 = 6.87 nM) and RARγ (Kd = 816 nM; AC50 = 148.7 nM). It demonstrates greater specific binding to RARα compared to retinoic acid , which exhibits little selectivity across RARα, β, or γ. AM80 exhibits antiproliferative effects against acute promyelocytic leukemia cells, inducing human promyelocytic leukemia HL-60 cell differentiation with an ED50 value of 0.79 nM. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells.

Description

Tamibarotene, a selective agonist of the retinoic acid receptor, was launched in Japan as an oral treatment for relapsed or refractory acute promyelocytic leukemia (APL). APL is a form of acute myeloid leukemia (AML) characterized by a deficiency in mature blood cells and an excess of immature cells called promyelocytes in the bone marrow and peripheral blood. The current standard of care for APL includes treatment with all-trans-retinoic acid (ATRA), either alone or in combination with chemotherapy. ATRA is a high affinity ligand for two types of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), each of which has three subtypes (-α, -β, and -γ). Activation of RARα by ATRA causes promyelocytes to differentiate and mature, thereby inhibiting their proliferation and inducing disease remission. Although ATRA is one of the most clinically successful retinoids, its usage is hampered by the high rate of adverse effects, instability, and the appearance of ATRA-resistant leukemia cells.Adverse events included retinoic acid syndrome, hyperleukocytosis, xerosis, cheilitis, hypertriglyceridemia, and hypercholesterolemia; however, these side effects were generally milder than with ATRA, which all patients had received previously. Examination of human samples taken from Phase II and III clinical trials revealed that fecal excretion was the major elimination route, and the metabolism of tamibarotene occurred primarily through hydroxylation and taurine conjugation. In vitro, the plasma protein binding of tamibarotene is shown to be ＞98% in rats, dogs, and humans. Tamibarotene is synthesized from 5,5,8,8-tetramethyl-5,6,7, 8-tetrahydronaphthalene in a four-step sequence consisting of regioselective nitration in the 2-position, reduction of the nitro group by hydrogenation to produce the corresponding aniline derivative, acylation of the aniline intermediate with 4-(carbomethoxy)benzoyl chloride, and hydrolysis of the methyl ester.

Chemical Properties

Crystalline Solid

Originator

Toko Yakuhin Kogyo (Japan)

Uses

Tamibarotene, a retinoic acid receptor-α(RARα) agonist, was approved for the treatment of relapsed or refractory acute promyelocytic leukemia (APL) in Japan on June, 2005 and is currently marketed by Nippon Shinyaku Co. This novel drug has shown high remission rate among patients who have recurrent disease after all trans retinoic acid therapy.

Uses

Synthetic retinoic acid receptor-a/?selective retinoid. Antineoplastic

Uses

Synthetic retinoic acid receptor-α/β-selective retinoid. Antineoplastic.

Uses

A RARα agonist that induces differentiation and apoptosis

Definition

ChEBI: A dicarboxylic acid monoamide resulting from the condensation of one of the carboxy groups of terephthalic acid with the amino group of 5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine.

brand name

Amnolake

Biological Activity

Retinoic acid receptor α (RAR α ) agonist that induces differentiation (ED 50 = 0.79 nM) and apoptosis of HL-60 cells in vitro . Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μ M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo .

Biochem/physiol Actions

Tamibarotene (Am80) is a RAR α agonist. Tamibarotene was developed to overcome resistance to ATRA and is currently approved in Japan for treatment of recurrent acute promyelocytic leukemia (APL). The compound induces HL-60 cells differentiation and apoptosis. Similarly to TTNPB, the compound neither binds to nor transactivates the RXRs. In contrast to TTNPB (pan RAR agonist), Tamibarotene is rather specific toward RAR α. The compound is approximate 10 times more potent than ATRA.

Synthesis

Several synthesis of tamibarotene have been disclosed in the literature including the process scale synthesis as shown in the scheme. The synthesis started with preparation of dichloride 134 in 82% yield from diol 133 by treating with concentrated HCL in DCM. Friedal Crafts reaction of dichloride 134 with acetanilide in the presence of aluminum chloride at -15??C for 2h provided acetanilide derivative 136 in 78% yield. In a single pot, the acetanilide was reacted with PCl5 and dimethylaniline at -25??C for 1.5h followed by quenching the reaction with methanol for 2h after addition at -25??C. Addition of dimethylaniline and terepthalic chloride mono-methylester at -30 - - 20??C for 1 hr provided the tamibarotene methyl easter 137 in 81% yield. Hydrolysis of the ester by heating with sodium hydroxide in MeOH:water mixture for 1h followed isolation and crystallization gave tamibarotene (XIX) in 92% yield.

storage

Store at RT

Tamibarotene Preparation Products And Raw materials

Raw materials

Preparation Products

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Tamibarotene Suppliers

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View Lastest Price from Tamibarotene manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Tamibarotene 94497-51-5
Price
US $0.00-0.00/KG
Min. Order
5mg
Purity
99%
Supply Ability
2000tons
Release date
2019-12-31
Shanghai Standard Technology Co., Ltd.
Product
Tamibarotene 94497-51-5
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-04-21
Career Henan Chemical Co
Product
Tamibarotene 94497-51-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-03-05

94497-51-5, TamibaroteneRelated Search:

Folic acid 4-Aminobenzoic acid Glycine Ethyl 2-(Chlorosulfonyl)acetate Vorinostat Homoharringtonine Pyrantel pamoate Temozolomide Lenalidomide 4-Chlorocarbonylbenzoic acid,methyl ester (Tamibarotene) N-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide (Tamibarotene) Anthranilic acid 2-NAPHTHALENAMINE, 5,6,7,8-TETRAHYDRO- 4-Ethyl-3-(1-methylethyl)benzenamine Tamibarotene CHEMBRDG-BB 4022344 phosphoric acid BENZOICACID

  • AM80
  • Tamibarotene
  • 4-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid
  • 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic Acid
  • Am 80 (pharmaceutical)
  • Amnolake
  • NSC 608000
  • Retinoid AM 80
  • 4-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalene-2-ylaminocarbonyl)benzoic acid
  • 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalen)-2-yl]aminocarbonyl]benzoic acid
  • 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethylnaphthalen-2-yl)amino]carbonyl]benzoic acid
  • C12864
  • 4-[(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbaMoyl]benzoic acid
  • 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetraMethyl-2-naphthalenyl)carbaMoyl]benzoic acid, 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetraMethyl-2-naphthyl)carbaMoyl] benzoic acid
  • TAMIBAROTENE,AM 80, AM-80, AM80
  • 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoicacid
  • -((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)benzoic acid
  • Amnoid
  • N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl)-2-naphthyl)terephthalamic acid
  • N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic acid
  • UNII-08V52GZ
  • Tamibarotene, >=99%
  • Tamibarotene(Am-80)
  • AM80; AM 80; AM-80
  • CS-1151
  • Benzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-
  • Tamibarotene USP/EP/BP
  • Butanoicacid,9-methoxy-
  • amibarotene
  • NSC 608000|||Am 80|||Amnolake
  • Oteseconazole Impurity 5
  • 94497-51-5
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Retinoids