ChemicalBook > CAS DataBase List > VOACANGINE

VOACANGINE

Product Name
VOACANGINE
CAS No.
510-22-5
Chemical Name
VOACANGINE
Synonyms
VOACANGINE;(-)-Voacangine;Carbomethoxyibogaine;12-Methoxyibogamine-18-carboxylic acid methyl ester;Ibogamine-18-carboxylic acid, 12-methoxy-, methyl ester
CBNumber
CB7433742
Molecular Formula
C22H28N2O3
Formula Weight
368.47
MOL File
510-22-5.mol
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VOACANGINE Property

Melting point:
223-224℃ (dec.)
Density 
1.25±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
Store at -20°C,protect from light
solubility 
DMF: 16 mg/ml; DMSO: 16 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.33 mg/ml
form 
A crystalline solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24692
Product name
Voacangine
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
24692
Product name
Voacangine
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
Cayman Chemical
Product number
24692
Product name
Voacangine
Purity
≥98%
Packaging
10mg
Price
$632
Updated
2024/03/01
TRC
Product number
V757300
Product name
(-)-Voacangine
Packaging
25mg
Price
$695
Updated
2021/12/16
TRC
Product number
V757300
Product name
(-)-Voacangine
Packaging
50mg
Price
$1200
Updated
2021/12/16
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VOACANGINE Chemical Properties,Usage,Production

Description

This alkaloid is of widespread occurrence, being found in Stemmadenia species and also is Vocanga africana, v. dregii and V. obtusa. It forms colourless needles when crystallized from MeOH and has [0'10 - 42° (c 1.0, CHCI3). It sublimes under vacuum at 135°CjO.01 mm and is readily soluble in CHC13 or Me2CO, but only sparingly so in EtOH or MeOH. Hydrolysis with KOH followed by acidification with HCl yields Ibogaine (q.v.).

Uses

(-)-Voacangine is a bisindole alkaloid with ether-?a-?go-?go-?related gene channel blocker activity in vitro. hERG channel blocker.

Definition

ChEBI: (-)-voacangine is a monoterpenoid indole alkaloid with formula C22H28N2O3, isolated from several plant species. It has a role as an angiogenesis inhibitor, an antineoplastic agent and a plant metabolite. It is a monoterpenoid indole alkaloid, a tertiary amino compound, a methyl ester, an organic heteropentacyclic compound and an alkaloid ester. It is a conjugate base of a (-)-voacangine(1+).

in vivo

Voacangine significantly suppresses in vitro angiogenesis, such as VEGF-induced tube formation and chemoinvasion[2].

References

lanot, Goutarel., Compt. rend., 241,986 (1955) Stauffacher, Seebeck., Helv. Chim. Acta, 41,169 (1958) Watts, Collera, Sandoval., Tetrahedron, 2, 173 (1958) Schuler, Verbeck, Warren.,J. Chern. Soc., 4776 (1958) Bartlett, Dickel, Taylor.,J. Amer. Chern. Soc., 80, 126 (1958) Renner, Prins, Stoll., Helv. Chim. Acta, 42,1572 (1959) Budzikiewicz etal., Bull. Soc. Chim. Fr., 1899 (1963)

VOACANGINE Preparation Products And Raw materials

Raw materials

Preparation Products

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VOACANGINE Suppliers

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View Lastest Price from VOACANGINE manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Voacangine 510-22-5
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-08
Hebei Kangcang new material Technology Co., LTD
Product
Voacangine 510-22-5
Price
US $9.00-70.00/g
Min. Order
10g
Purity
99%
Supply Ability
10 tons
Release date
2024-03-27

510-22-5, VOACANGINERelated Search:

3-(2-methylaminoethyl)-1H-indol-5-ol N,N-Dimethyl-5-methoxytryptamine 2-TERT-BUTYL-1H-INDOLE 3,5-Dimethylpiperidine METHYL BETA-(DIMETHYLAMINO)ISOBUTYRATE Methyl piperidine-3-carboxylate (R)-Methyl nipecotate 2-Piperidineethanol Bufotenine 1-METHYL-1-CYCLOHEXANECARBOXYLIC ACID N,N-DIPROPYLTRYPTAMINE INDOLE-2-ACETIC ACID CHEMBRDG-BB 5569568 5-METHOXY-N,N-DIETHYLTRYPTAMINE(5-MEO-DET) VOACANGINE 2,6-DIMETHYLCYCLOHEXYLAMINE 3-AMINO-HEPTANOIC ACID 5-Methoxy-N,N-dipropyltryptamine

  • VOACANGINE
  • 12-Methoxyibogamine-18-carboxylic acid methyl ester
  • Carbomethoxyibogaine
  • Ibogamine-18-carboxylic acid, 12-methoxy-, methyl ester
  • (-)-Voacangine
  • 510-22-5