2-(2-BOC-AMINOETHOXY)ETHANOL

Product Name: 2-(2-BOC-AMINOETHOXY)ETHANOL
CAS No.: 139115-91-6
Chemical Name: 2-(2-BOC-AMINOETHOXY)ETHANOL
Synonyms: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbaMate;BocNH-PEG2-OH;tert-butyl N-[2-(2-hydroxyethoxy)ethyl]carbamate;125303;Boc-NPEG2;Boc-NH-PEG2;CAS_139115-91-6;PROTAC Linker 11;N-Boc-PEG2-alcohol;BocNH-PEG2-alcohol
CBNumber: CB7434901
Molecular Formula: C9H19NO4
Formula Weight: 205.25
MOL File: 139115-91-6.mol

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2-(2-BOC-AMINOETHOXY)ETHANOL Property

Boiling point:: 332.9±22.0 °C(Predicted)
Density: 1.061 g/mL at 25 °C
refractive index: n20/D1.454
Flash point:: >110℃
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: clear liquid
pka: 12.20±0.46(Predicted)
color: Colorless to Light orange to Yellow
InChI: InChI=1S/C9H19NO4/c1-9(2,3)14-8(12)10-4-6-13-7-5-11/h11H,4-7H2,1-3H3,(H,10,12)
InChIKey: KSFVNEXYCULLEJ-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NCCOCCO

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Safety

Hazard Codes: T
Risk Statements: 25-36-37-38
Safety Statements: 36/39-45
RIDADR: 2810
WGK Germany: 3
HS Code: 2924.19.8000
HazardClass: 6.1
PackingGroup: Ⅲ

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 749648
Product name: 2-[2-(Boc-amino)ethoxy]ethanol
Purity: 97%
Packaging: 5G
Price: $66.85
Updated: 2025/07/31

Sigma-Aldrich

Product number: 749648
Product name: 2-[2-(Boc-amino)ethoxy]ethanol
Purity: 97%
Packaging: 25G
Price: $166
Updated: 2025/07/31

TCI Chemical

Product number: B5745
Product name: 2-[2-[(tert-Butoxycarbonyl)amino]ethoxy]ethanol
Purity: >98.0%(GC)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TCI Chemical

Product number: B5745
Product name: 2-[2-[(tert-Butoxycarbonyl)amino]ethoxy]ethanol
Purity: >98.0%(GC)
Packaging: 25g
Price: $144
Updated: 2025/07/31

TRC

Product number: B618575
Product name: 2-(2-Boc-aminoethoxy)ethanol
Packaging: 5g
Price: $50
Updated: 2021/12/16

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2-(2-BOC-AMINOETHOXY)ETHANOL Chemical Properties,Usage,Production

Description

N-Boc-PEG2-alcohol is a PEG linker containing a hydroxyl group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

2-[2-(Boc-amino)ethoxy]ethanol is N-terminal protected 2-(2-aminoethoxy)ethanol. It is generally used as a molecular spacer/linker. Some of such applications are:

Synthesis of biotinylated HaloLigands to prepare quantum dot adducts for HaloTag protein-mediated specific labeling of live cells.
It is one of the key precursors for the total synthesis of tyroscherin and photo-activatable tyroscherin-based affinity reagent used for identification of tyroscherin binding proteins.
It can be used to link HaloTag enzyme with fluorescent zinc indicator, ZIMIR to monitor the dynamics of regulated secretion of zinc in real time.
It can also be used to synthesize amphiphiles for DNA and siRNA delivery.

Synthesis

24424-99-5

929-06-6

139115-91-6

Preparation of compound 100: Di-tert-butyl dicarbonate (4.36 g, 20 mmol) was slowly added to a solution of 2-(2-aminoethoxy)ethanol (2.10 g, 20 mmol) in dichloromethane (40 mL) at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was concentrated and purified by column chromatography (eluent: 50-70% ethyl acetate/hexane) to afford compound 100 as a colorless oil (4.21 g, 100% yield). Characterization data: - Analytical TLC (silica gel 60), unfolding agent was 80% ethyl acetate in hexane solution, Rf = 0.30. - 1H NMR (400 MHz, CDCl3) δ 5.28 (br s, 1H), 3.74 (br t, J = 4.1 Hz, 2H), 3.59-3.54 (m, 4H), 3.32-3.28 (m, 2H), 3.08 (br s, 1H), 1.44 (s, 9H). - 13C NMR (100 MHz, CDCl3) δ 156.1, 79.2, 72.2, 70.2, 61.5, 40.3, 28.3. - IR (CH2Cl2) 3228 (br), 3035, 2927, 2855, 1523 cm-1. - LRMS (ESI) m/z 228.0 (M+ + Na). - HRMS (ESI) calculated value C9H20NO4 (M+ + H) m/z 206.1392, measured value 206.1390.

IC 50

PEGs; Alkyl/ether

References

[1] Patent: WO2016/181312, 2016, A1. Location in patent: Paragraph 0386-0389
[2] Journal of Medicinal Chemistry, 2000, vol. 43, # 3, p. 475 - 487
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 2, p. 727 - 729
[4] Journal of the American Chemical Society, 2013, vol. 135, # 16, p. 6184 - 6191
[5] Journal of the American Chemical Society, 2017, vol. 139, # 5, p. 2118 - 2118

2-(2-BOC-AMINOETHOXY)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-BOC-AMINOETHOXY)ETHANOL Suppliers

Americas 1 China 145 Europe 2 India 4 Japan 1 Switzerland 1 United Kingdom 1 United States 12 Global 167

Nanjing Yuye Biotechnology Co., Ltd.

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View Lastest Price from 2-(2-BOC-AMINOETHOXY)ETHANOL manufacturers

LAURENT

Product: BocNH-PEG2-OH 139115-91-6
Price: US $1108.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 300KG
Release date: 2025-11-18

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-NH-PEG2 139115-91-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-02-04

Xian confluore Biological Technology Co., Ltd.

Product: NHBoc-PEG2-OH 139115-91-6
Price: US $0.00/g
Min. Order: 100g
Purity: >98.00%
Supply Ability: 1000g
Release date: 2024-03-25

139115-91-6, 2-(2-BOC-AMINOETHOXY)ETHANOLRelated Search:

2-HYDROXYMETHYL-4-BOC-MORPHOLINE 3-CARBOXYMETHOXY-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER N-(TERT-BUTOXYCARBONYL)-D-GLUCOSAMINE 2-(2-Aminoethoxy)ethanol O-(2-AMINOETHYL)-O'-(2-(BOC-AMINO)ETHYL) 3-CARBOXYMETHOXY-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 4-BOC-2-MORPHOLINECARBOXYLIC ACID O-(2-(BOC-AMINO)-ETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG6 O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)OCTAETHYLENE GLYCOL 2-(2-BOC-AMINOETHOXY)ETHANOL 3-CARBOXYMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Boc-1-amino-3,6-dioxa-8-octanediamine O-(2-AMINOETHYL)-O-(2-(BOC-AMINO)ETHYL)DECAETHYLENE GLYCOL 5R-T-BUTYLOXYCARBONYLAMINOMETHYL-3S,4R-DIBENZYLOXY-TETRAHYDROFURANE-2R-CARBOXYLIC ACID 5S-T-BUTYLOXYCARBONYLAMINOMETHYL-3S,4R-DIBENZYLOXY-TETRAHYDROFURANE-2R-CARBOXYLIC ACID BOC-PEG-ACID 3-METHOXYCARBONYLMETHOXY-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 5S-T-BUTYLOXYCARBONYLAMINOMETHYL-3S,4R-DIBENZYLOXY-TETRAHYDROFURANE-2S-CARBOXYLIC ACID

BOC-2-(2-AMINOETHOXY)ETHANOL

Carbamic acid, [2-(2-hydroxyethoxy)ethyl]-, 1,1-dimethylethyl ester (9CI)

2-(2-tert-butyloxycarbonylaminoethoxy)ethanol

2-(2-BOC-AMINOETHOXY)ETHANOL

BocNH-PEG2-OH

N-Boc-PEG2-alcohol

N-Boc-2-(2-hydroxyethoxy)ethylamine

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbaMate

[2-(2-Hydroxyethoxy)ethyl]carbamic acid 1,1-dimethylethyl ester

2-(2-tert-Butoxycarbonylaminoethoxy)ethanol

N-[2-(2-Hydroxyethoxy)ethyl]carbamic acid tert-butyl ester

2-[2-(Boc-amino)ethoxy]ethanol 97%

tert-butyl N-[2-(2-hydroxyethoxy)ethyl]carbamate

CAS_139115-91-6

125303

PROTAC Linker 11

Boc-NH-PEG2

Carbamic acid, N-[2-(2-hydroxyethoxy)ethyl]-, 1,1-dimethylethyl ester

t-boc-N-amido-PEG2-alcohol

[2-(2-Hydroxyethoxy)ethyl]carbamic Acid tert-Butyl Ester

N-Boc-2-(2-hydroxyethoxy)ethanamine

tert-butyl 2-amino-3-(2-hydroxyethoxy)propanoate

BocNH-PEG2-alcohol

Boc-NPEG2

139115-91-6

Miscellaneous

N-BOC

pharmacetical

peg