4-BOC-2-MORPHOLINECARBOXYLIC ACID
- Product Name
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
- CAS No.
- 189321-66-2
- Chemical Name
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
- Synonyms
- BOC-COP;BOC-COP-OH;Boc-(R,S)-Cop-OH;RARECHEM EM WB 0087;Boc-2-carboxymorpholine;(R,S)-BOC-2-CARBOXYMORPHOLINE;BOC-(R,S)-2-CARBOXYMORPHOLINE;4-BOC-2-MORPHOLINECARBOXYLIC ACID;N-Boc-2-morpholinecarboxylic acid;4-Bocmorpholine-2-carboxylic acid
- CBNumber
- CB2410841
- Molecular Formula
- C10H17NO5
- Formula Weight
- 231.25
- MOL File
- 189321-66-2.mol
4-BOC-2-MORPHOLINECARBOXYLIC ACID Property
- Melting point:
- >139oC (dec.)
- Boiling point:
- 369.5±42.0 °C(Predicted)
- Density
- 1.230±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly, Heated)
- form
- Solid
- pka
- 3.25±0.20(Predicted)
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
- InChIKey
- LGWMTRPJZFEWCX-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCOC(C(O)=O)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D472750
- Product name
- 4-(1,1-Dimethylethyl)Ester2,4-MorpholinedicarboxylicAcid
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- D472750
- Product name
- 4-(1,1-Dimethylethyl)Ester2,4-MorpholinedicarboxylicAcid
- Packaging
- 5g
- Price
- $495
- Updated
- 2021/12/16
- Product number
- 36246
- Product name
- Boc-Cop-OH
- Packaging
- 1g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- CHM0025532
- Product name
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1034.88
- Updated
- 2021/12/16
- Product number
- CHM0025532
- Product name
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $2067.45
- Updated
- 2021/12/16
4-BOC-2-MORPHOLINECARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
4-BOC-2-MORPHOLINECARBOXYLIC ACID is white to off-white powder
Uses
4-BOC-2-MORPHOLINECARBOXYLIC ACID is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multipl e myelomas.
Uses
4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas.
Synthesis
500789-41-3
189321-66-2
Methyl 4-(tert-butoxycarbonyl)morpholine-2-carboxylate (251 mg, 1.02 mmol) was used as a raw material and dissolved in methanol (15 mL). To this solution was added 1 mol/L aqueous potassium hydroxide solution (3 mL). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, water was added to the mixture and the pH was adjusted with 5% aqueous citric acid solution. subsequently, the reaction mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 219 mg (93% yield) of the target product 4-Boc-2-morpholinecarboxylic acid as a colorless powder. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ1.40 (9H, s), 2.70 (1H, dd, J=41.6,15.3 Hz), 3.03-3.09 (1H, m), 3.43-3.54 (2H, m), 3.78 (1H, m), 3.85 (1H, dt, J=11.6,3.7 Hz), 4.04 (1H, dd, J=8.6,3.7Hz), 12.73 (1H, brs).
References
[1] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 58
4-BOC-2-MORPHOLINECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
4-BOC-2-MORPHOLINECARBOXYLIC ACID Suppliers
- Tel
- 021-50795510 4000665055
- sy-c6@accelachem.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 0838-5675166 15883665058
- Fax
- 0838-5675535
- nbcxkj@126.com
- Country
- China
- ProdList
- 918
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 86-0571-85151182
- Fax
- 86-0571-85151182
- Country
- China
- ProdList
- 5691
- Advantage
- 66
View Lastest Price from 4-BOC-2-MORPHOLINECARBOXYLIC ACID manufacturers
- Product
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID 189321-66-2
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 4-BOC-2-MORPHOLINECARBOXYLIC ACID 189321-66-2
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 95%-98%
- Supply Ability
- 100kg
- Release date
- 2019-09-04