3-(Methylamino)propanoic acid, N-BOC protected
- Product Name
- 3-(Methylamino)propanoic acid, N-BOC protected
- CAS No.
- 124072-61-3
- Chemical Name
- 3-(Methylamino)propanoic acid, N-BOC protected
- Synonyms
- Boc-N-Me-β-Ala;Boc-N-Me-β-Ala-OH;Boc-N-Me-Beta-Ala;N-Boc-N-methyl-β-alanine;N-Boc-N-Methyl-b-alanine;Boc-N-Methyl-beta-alanine;3-(MethylaMino)propanoic aci;N-BOC-3-(METHYLAMINO)PROPANOIC ACID;3-[(Boc)(methyl)amino]propionic Acid;3-(MethylaMino)propanoic acid, N-BOC
- CBNumber
- CB8958013
- Molecular Formula
- C9H17NO4
- Formula Weight
- 203.24
- MOL File
- 124072-61-3.mol
3-(Methylamino)propanoic acid, N-BOC protected Property
- Melting point:
- 59-62
- Boiling point:
- 307.4±21.0 °C(Predicted)
- Density
- 1.113±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 4.46±0.10(Predicted)
- color
- Pale yellow
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B810715
- Product name
- 3-((tert-Butoxycarbonyl)(methyl)amino)propanoicAcid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B810715
- Product name
- 3-((tert-Butoxycarbonyl)(methyl)amino)propanoicAcid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FB32983
- Product name
- Boc-N-methyl-b-alanine
- Packaging
- 2g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 009279
- Product name
- 3-[(tert-Butoxycarbonyl)(methyl)amino]-propanoic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- OR7830
- Product name
- 3-(Methylamino)propanoicacid,N-BOCprotected
- Purity
- 97%
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
3-(Methylamino)propanoic acid, N-BOC protected Chemical Properties,Usage,Production
Synthesis
3303-84-2
74-88-4
124072-61-3
Step 1: Synthesis of 3-(tert-butoxycarbonyl(methyl)amino)propionic acid 1. a mineral oil suspension of 60% NaH (0.528 g, 13.21 mmol) was washed with hexane (2 x 10 mL) to remove the mineral oil. 2. The washed NaH was suspended in anhydrous THF (6 mL) and the mixture was cooled to 0°C. 3. A solution of Boc-β-alanine (1 g, 5.29 mmol) in anhydrous THF (6 mL) was slowly added with stirring. 4. After 5 min, anhydrous THF (6 mL) solution of iodomethane (0.823 mL, 13.21 mmol) was added dropwise. 5. The reaction mixture was stirred overnight at 0 °C to room temperature. 6. Upon completion of the reaction, the reaction was quenched with ice-cold deionized water (50 mL) and the mixture was washed with ether (25 mL). 7. Separate the aqueous layer and acidify to pH < 2 with concentrated aqueous hydrochloric acid (3 mL). 8. Extract the acidified aqueous layer with ethyl acetate (3 x 20 mL). 9. Combine the organic phases, dry with anhydrous sodium sulfate and concentrate under reduced pressure to afford the target product N-Boc-3-(methylamino)propionic acid (1.095 g, quantitative yield) as a yellow oil.
References
[1] Patent: US2014/66426, 2014, A1. Location in patent: Paragraph 0779
[2] Patent: WO2014/32801, 2014, A1. Location in patent: Page/Page column 157
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 11, p. 1562 - 1568
[4] Patent: US5428021, 1995, A
3-(Methylamino)propanoic acid, N-BOC protected Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(Methylamino)propanoic acid, N-BOC protected manufacturers
- Product
- 3-((Tert-butoxycarbonyl)(methyl)amino)propanoic acid 124072-61-3
- Price
- US $75.00-750.00/KG
- Min. Order
- 1KG
- Purity
- 0.98
- Supply Ability
- 20 tons
- Release date
- 2023-10-25