1-N-Boc-3-Azetidinecarboxylic acid

Product Name: 1-N-Boc-3-Azetidinecarboxylic acid
CAS No.: 142253-55-2
Chemical Name: 1-N-Boc-3-Azetidinecarboxylic acid
Synonyms: 1-(TERT-BUTOXYCARBONYL)AZETIDINE-3-CARBOXYLIC ACID;AZETIDINE-1,3-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER;BOC-AZE(3)-OH;CAS:142253-55-2;RARECHEM BK PT 0278;Boc-3-Azetidinecarboxylic acid;BOC-AZETIDINE-3-CARBOXYLIC ACID;1-Boc-Azetidine3-Carboxylicacide;Boc-N-Azetidine-3-carboxylic acid;N-BOC-3-AZETIDINE CARBOXYLIC ACID
CBNumber: CB7123126
Molecular Formula: C9H15NO4
Formula Weight: 201.22
MOL File: 142253-55-2.mol

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1-N-Boc-3-Azetidinecarboxylic acid Property

Melting point:: 100.1-101.9°C
Boiling point:: 321.0±35.0 °C(Predicted)
Density: 1.246±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 4.21±0.20(Predicted)
form: Crystalline Powder
color: White
BRN: 8832105
InChI: InChI=1S/C9H15NO4/c1-9(2,3)14-8(13)10-4-6(5-10)7(11)12/h6H,4-5H2,1-3H3,(H,11,12)
InChIKey: NCADHSLPNSTDMJ-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(C(O)=O)C1
CAS DataBase Reference: 142253-55-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-37-26
WGK Germany: 3
TSCA: No
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 09928
Product name: 1-Boc-azetidine-3-carboxylic acid
Purity: ≥98.0% (TLC)
Packaging: 500mg
Price: $407
Updated: 2023/06/20

TCI Chemical

Product number: B3540
Product name: 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $89
Updated: 2025/07/31

TCI Chemical

Product number: B3540
Product name: 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $265
Updated: 2025/07/31

TRC

Product number: B630008
Product name: 1-Boc-azetidine-3-carboxylic acid
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Usbiological

Product number: 236079
Product name: Boc-azetidine-3-carboxylic acid 98+%
Packaging: 250mg
Price: $170
Updated: 2021/12/16

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1-N-Boc-3-Azetidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

light yellow powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

36476-78-5

142253-55-2

General procedure for the synthesis of 1-Boc-azetidine-3-carboxylic acid from di-tert-butyl dicarbonate and 3-acridinecarboxylic acid: Example 4 Synthesis of 6-(3-{[(benzylsulfonyl)amino]carbonyl}azetidin-1-yl)-5-cyano-2-(difluoromethyl)nicotinate (a) Preparation of ethyl 1-(tert-butoxycarbonyl)azetidine-3-carboxylate Di-tert-butyl dicarbonate (25.535 g, 117 mmol) dissolved in methanol (70 mL) was added dropwise to a stirred solution of azetidine-3-carboxylic acid (10.11 g, 100 mmol) and triethylamine (27.8 mL, 200 mmol) in methanol (105 mL) over a period of 20 min. The reaction was carried out at room temperature (mild exotherm was observed) with continuous stirring for 18 hours. Upon completion of the reaction, the mixture was evaporated to dryness, tetrahydrofuran (120 mL) was added and evaporated again to afford the crude 1-(tert-butoxycarbonyl)azetidine-3-carboxylic acid, which could be used in the next step without further purification. Yield: 25.89 g (128%). 1H NMR (400 MHz, CDCl3) δ 1.43 (9H, s), 3.21-3.34 (1H, m), 4.00-4.13 (4H, m).

References

[1] Patent: WO2008/4946, 2008, A1. Location in patent: Page/Page column 90-91
[2] Patent: US2008/171732, 2008, A1. Location in patent: Page/Page column 36
[3] Patent: WO2008/85119, 2008, A1. Location in patent: Page/Page column 175-176
[4] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 98
[5] Patent: WO2008/95912, 2008, A2. Location in patent: Page/Page column 77

1-N-Boc-3-Azetidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Acetonitrile Toluene Di-tert-butyl dicarbonate Benzylamine Formaldehyde Palladium Trifluoroacetic anhydride Hydrochloric acid Dichloromethane Methanol Sodium hydroxide Diethyl malonate

Preparation Products

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1-N-Boc-3-Azetidinecarboxylic acid Suppliers

Americas 1 Canada 1 China 294 Europe 2 France 2 Germany 8 India 8 Japan 4 South Korea 1 Switzerland 1 Ukraine 1 United Kingdom 12 United States 56 Global 391

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View Lastest Price from 1-N-Boc-3-Azetidinecarboxylic acid manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1-Boc-azetidine-3-carboxylic acid 142253-55-2
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-24

Henan Aochuang Chemical Co.,Ltd.

Product: 1-N-Boc-3-Azetidinecarboxylic acid 142253-55-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-N-Boc-3-Azetidinecarboxylic acid 142253-55-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

142253-55-2, 1-N-Boc-3-Azetidinecarboxylic acidRelated Search:

tert-Butyl acetate 1,2,3,4-Butanetetracarboxylic acid 3-Azetidinecarboxylic acid ISOBUTANE tert-Butanol Folic acid Quinolinic acid Ethyl 2-(Chlorosulfonyl)acetate 2,5-PYRIDINEDICARBOXYLIC ACID tert-Butyl peroxyacetate Lithium tri-tert-butoxyaluminum hydride Hyaluronic acid n-Butane Citric acid Ascoric Acid 3-(Methylamino)propanoic acid, N-BOC protected 1-Boc-Azetidine-3-yl-methanol Azetidine

RARECHEM BK PT 0278

1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid

Boc-N-Azetidine-3-carboxylic acid

1,3-Azetidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester

1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid, 1-(tert-Butoxycarbonyl)azetane-3-carboxylic acid

1-(<i>tert</i>-Butoxycarbonyl)azetidine-3-carboxylic acid

1-Boc-3-Azetidine-3-carboxylic acid

1-(tert-butoxy-oxomethyl)-3-azetidinecarboxylic acid

1-[(2-methylpropan-2-yl)oxycarbonyl]azetidine-3-carboxylic acid

Azetidine-1,3-dicarboxylic acid 1-tert-butyl ester

N-BOC-3-AZETIDINE CARBOXYLIC ACID

N-BOC-AZETIDINE-3-CARBOXYLIC ACID

N-ALPHA-T-BUTOXYCARBONYL-AZETIDE-3-CARBOXYLIC ACID

N-ALPHA-T-BUTOXYCARBONYL-AZETIDINE-3-CARBOXYLIC ACID

N-ALPHA-T-BOC-L-AZETIDINE-3-CARBOXYLIC ACID

BOC-AZE(3)-OH

BOC-AZETIDINE-3-CARBOXYLIC ACID

AZETIDINE-3-CARBOXYLIC ACID, N-BOC PROTECTED

AZETIDINE-1,3-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER

1-(TERT-BUTOXYCARBONYL)AZETIDINE-3-CARBOXYLIC ACID

1-N-BOC-3-AZETIDINECARBOXYLIC ACID

BOC-AZETIDINE-3-CARBOXYLIC ACID 98%

1-Boc-Azetidine3-Carboxylicacide

Azetidine-3-carboxylic acid, N-BOC protected 97%

1-N-Boc-Azetidine-3-carboxylic acid

3-carboxyazetidine-1-carboxylic acid tert-butyl ester

1-BOC-AZETIDINE-3-CARBOXYLIC ACID 98+%

(Tert-Butoxy)Carbonyl Azetidine-3-carboxylic acid

1-BOC-AZETIDINE-3-CARBOXYLIC ACID

1-(tert-Butoxycarbonyl)azetidine-3-carboxylic Acid &gt

1-Boc-3-Azetidine-3-carboxylicaci

1-N-Boc-3-Azetidinecarboxylic acid USP/EP/BP

Boc-3-Azetidinecarboxylic acid

N-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid

CAS:142253-55-2

1-N-BOC-Azetidine-3-carboxylic acid - [B3069]

142253-55-2

159749-28-8

C9H14NO4

Peptide Synthesis

Others

Specialty Synthesis

Unnatural Amino Acid Derivatives

Peptide

Carboxylic Acids

Ring Systems

Others

Peptide Synthesis

Unnatural Amino Acid Derivatives

B-Amino

Unusual amino acids

pharmacetical

Carboxylic Acids

Azetidine

Organic acids

Azetidines