ChemicalBook > CAS DataBase List > 4-BOC-2-MORPHOLINECARBOXYLIC ACID

4-BOC-2-MORPHOLINECARBOXYLIC ACID

Product Name
4-BOC-2-MORPHOLINECARBOXYLIC ACID
CAS No.
189321-66-2
Chemical Name
4-BOC-2-MORPHOLINECARBOXYLIC ACID
Synonyms
BOC-COP;BOC-COP-OH;Boc-(R,S)-Cop-OH;RARECHEM EM WB 0087;Boc-2-carboxymorpholine;(R,S)-BOC-2-CARBOXYMORPHOLINE;BOC-(R,S)-2-CARBOXYMORPHOLINE;4-BOC-2-MORPHOLINECARBOXYLIC ACID;N-Boc-2-morpholinecarboxylic acid;4-Bocmorpholine-2-carboxylic acid
CBNumber
CB2410841
Molecular Formula
C10H17NO5
Formula Weight
231.25
MOL File
189321-66-2.mol
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4-BOC-2-MORPHOLINECARBOXYLIC ACID Property

Melting point:
>139oC (dec.)
Boiling point:
369.5±42.0 °C(Predicted)
Density 
1.230±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Ethyl Acetate (Slightly, Heated)
form 
Solid
pka
3.25±0.20(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)
InChIKey
LGWMTRPJZFEWCX-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCOC(C(O)=O)C1
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Safety

Hazard Codes 
Xi
Risk Statements 
36-51
Safety Statements 
26
HS Code 
29334900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D472750
Product name
4-(1,1-Dimethylethyl)Ester2,4-MorpholinedicarboxylicAcid
Packaging
1g
Price
$120
Updated
2021/12/16
TRC
Product number
D472750
Product name
4-(1,1-Dimethylethyl)Ester2,4-MorpholinedicarboxylicAcid
Packaging
5g
Price
$495
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
36246
Product name
Boc-Cop-OH
Packaging
1g
Price
$365
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0025532
Product name
4-BOC-2-MORPHOLINECARBOXYLIC ACID
Purity
95.00%
Packaging
1G
Price
$1034.88
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0025532
Product name
4-BOC-2-MORPHOLINECARBOXYLIC ACID
Purity
95.00%
Packaging
5G
Price
$2067.45
Updated
2021/12/16
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4-BOC-2-MORPHOLINECARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

4-BOC-2-MORPHOLINECARBOXYLIC ACID is white to off-white powder

Uses

4-BOC-2-MORPHOLINECARBOXYLIC ACID is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multipl e myelomas.

Uses

4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid is used in the preparation of potent and selective 3-phosphoinositide-dependent kinase 1 (PDK 1) inhibitors used in the treatment of multiple myelomas.

Synthesis

500789-41-3

189321-66-2

Methyl 4-(tert-butoxycarbonyl)morpholine-2-carboxylate (251 mg, 1.02 mmol) was used as a raw material and dissolved in methanol (15 mL). To this solution was added 1 mol/L aqueous potassium hydroxide solution (3 mL). The reaction mixture was stirred at room temperature for 8 hours. Upon completion of the reaction, water was added to the mixture and the pH was adjusted with 5% aqueous citric acid solution. subsequently, the reaction mixture was extracted with ethyl acetate. The organic phase was washed with saturated brine and dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give 219 mg (93% yield) of the target product 4-Boc-2-morpholinecarboxylic acid as a colorless powder. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ1.40 (9H, s), 2.70 (1H, dd, J=41.6,15.3 Hz), 3.03-3.09 (1H, m), 3.43-3.54 (2H, m), 3.78 (1H, m), 3.85 (1H, dt, J=11.6,3.7 Hz), 4.04 (1H, dd, J=8.6,3.7Hz), 12.73 (1H, brs).

References

[1] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 58

4-BOC-2-MORPHOLINECARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-BOC-2-MORPHOLINECARBOXYLIC ACID Suppliers

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View Lastest Price from 4-BOC-2-MORPHOLINECARBOXYLIC ACID manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-BOC-2-MORPHOLINECARBOXYLIC ACID 189321-66-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Career Henan Chemical Co
Product
4-BOC-2-MORPHOLINECARBOXYLIC ACID 189321-66-2
Price
US $5.00/KG
Min. Order
1KG
Purity
95%-98%
Supply Ability
100kg
Release date
2019-09-04

189321-66-2, 4-BOC-2-MORPHOLINECARBOXYLIC ACIDRelated Search:

2-HYDROXYMETHYL-4-BOC-MORPHOLINE (S)-N-Boc-2-morpholinecarboxylic acid (S)-N-Boc-2-Hydroxymethylmorpholine (S)-morpholine-2-carboxylic acid 3-(Methylamino)propanoic acid, N-BOC protected 2-Hydroxymethylmorpholine 2-MORPHOLINECARBOXYLIC ACID HCL (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI) 4-N-BOC-3-MORPHOLINECARBOXYLIC ACID MORFOLINE METHYLCARBAMATE 4-BOC-2-MORPHOLINECARBOXYLIC ACID 4-METHYL-MORPHOLINE-2-CARBOXYLIC ACID 2-(2-BOC-AMINOETHOXY)ETHANOL 4-BOC-2-MORPHOLINECARBALDEHYDE Propanoic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy- (9CI) 1-N-BOC-MORPHOLINE TERT-BUTYL ETHYL3-HYDROXYPROPYLCARBAMATE

  • BOC-COP
  • BOC-COP-OH
  • BOC-(R,S)-2-CARBOXYMORPHOLINE
  • 4-BOC-2-MORPHOLINECARBOXYLIC ACID
  • 4-(TERT-BUTOXYCARBONYL)MORPHOLINE-2-CARBOXYLIC ACID
  • N-Boc-2-morpholinecarboxylic acid
  • RARECHEM EM WB 0087
  • (R,S)-BOC-2-CARBOXYMORPHOLINE
  • Morpholine-2,4-dicarboxylic acid 4-tert-butyl ester
  • Boc-2-carboxymorpholine
  • 4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid
  • 2,4-Morpholinedicarboxylic acid, 4-(1,1-dimethylethyl) ester
  • 4-[(2-methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid
  • Boc-(R,S)-2-carboxymorpholine≥ 98% (NMR)
  • Boc-(R,S)-Cop-OH
  • N-Boc-Morpholine-2-carboxylic acid, 95+%
  • Morpholine-2-carboxylic acid, N-BOC protected 95+%
  • Morpholine-2-carboxylic acid, N-BOC protected
  • 4-Bocmorpholine-2-carboxylic acid
  • 189321-66-2
  • pharmacetical
  • Heterocycles series
  • Carboxylic Acids
  • Morpholines & Thiomorpholines
  • Carboxylic Acids
  • Morpholines & Thiomorpholines