1-N-BOC-MORPHOLINE

Product Name: 1-N-BOC-MORPHOLINE
CAS No.: 220199-85-9
Chemical Name: 1-N-BOC-MORPHOLINE
Synonyms: N-Boc-Morpholine;1-N-BOC-MORPHOLINE;4-Boc-morpholine, 98%;Sitagliptin Impurity 134;tert-Butyl Morpholine-4-carboxylate;4-Morpholinecarboxylic acid tert-butyl ester; 4-Morpholinecarboxylic acid, 1,1-dimethylethyl ester
CBNumber: CB02456290
Molecular Formula: C9H17NO3
Formula Weight: 187.24
MOL File: 220199-85-9.mol

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1-N-BOC-MORPHOLINE Property

Melting point:: 57-60℃
Boiling point:: 253.8±33.0 °C(Predicted)
Density: 1.065±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -1.58±0.20(Predicted)

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B810113
Product name: tert-ButylMorpholine-4-carboxylate
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 126810
Product name: tert-Butylmorpholine-4-carboxylate
Purity: >95%
Packaging: 1g
Price: $28
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143373
Product name: tert-Butyl morpholine-4-carboxylate
Packaging: 5G
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-FT
Product name: tert-Butyl morpholine-4-carboxylate
Purity: 98.0%
Packaging: 5G
Price: $79
Updated: 2021/12/16

Matrix Scientific

Product number: 126810
Product name: tert-Butylmorpholine-4-carboxylate
Purity: >95%
Packaging: 5g
Price: $82
Updated: 2021/12/16

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1-N-BOC-MORPHOLINE Chemical Properties,Usage,Production

Synthesis

110-91-8

24424-99-5

220199-85-9

The general procedure for the synthesis of tert-butyl morpholine-4-carboxylate from morpholine and di-tert-butyl dicarbonate is as follows: morpholine (1 mmol) is added to a solution of guanidine hydrochloride (15 mol%) and di-tert-butyl dicarbonate (1.2 mmol) in ethanol (1 mL) containing a magnetic stirrer, and the mixture is stirred at 35-40 °C until the reaction is complete (monitored by TLC or GC). Upon completion of the reaction, the ethanol is evaporated under vacuum and the residue is washed with water to remove the catalyst or dissolved in dichloromethane (or ethyl acetate) and filtered to separate the catalyst. If an organic solvent is used for post-treatment, evaporation of the organic solvent gives an almost pure product. If excess di-tert-butyl dicarbonate is used, the product can be washed with petroleum ether or hexane to recover the residual di-tert-butyl dicarbonate. If necessary, the product can be further purified by crystallization (using a solvent mixture of hexane and dichloromethane, or ethyl ether and petroleum ether) or by silica gel column chromatography (using ethyl acetate-hexane, 1:6, as eluent).

References

[1] Tetrahedron Letters, 2006, vol. 47, # 46, p. 8039 - 8042
[2] Synthesis, 2006, # 16, p. 2784 - 2788
[3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532
[4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043

1-N-BOC-MORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-N-BOC-MORPHOLINE Suppliers

China 48 India 1 United Kingdom 1 United States 6 Global 56

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220199-85-9, 1-N-BOC-MORPHOLINERelated Search:

MORPHOLINE-4-SULFONYL CHLORIDE 4-Chlorosulfonylimidazole tert-Butyl (2S,3R)-(+)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate 4-BOC-2-(4-CHLOROPHENYL)-2-METHYLMORPHOLINE MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER (5S)-N-(tert-Butoxycarbonyl)-3,4,5,6-tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one 3-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate 2-HYDROXYMETHYL-4-BOC-MORPHOLINE 4-BOC-2-MORPHOLINECARBOXYLIC ACID 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 3-(2-CARBOXY-ETHYL)-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER (5R)-N-(TERT-BUTOXYCARBONYL)-3,4,5,6-TETRAHYDRO-5-PHENYL-4(H)-1,4-OXAZIN-2-ONE 2-CARBOXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 9-BOC-6-OXA-9-AZASPIRO[4.5]DECANE TERT-BUTYL (S)-(-)-5-BENZYL-2-OXO-4-MORPHOLINECARBOXYLATE TERT-BUTYL 6-OXO-2,3-DIPHENYL-4-MORPHOLINECARBOXYLATE TERT-BUTYL 3-[(Z)-2-METHOXY-2-OXOETHYLIDENE]-2-OXO-4-MORPHOLINECARBOXYLATE

1-N-BOC-MORPHOLINE

tert-Butyl Morpholine-4-carboxylate

N-Boc-Morpholine

4-Morpholinecarboxylic acid, 1,1-dimethylethyl ester

4-Morpholinecarboxylic acid tert-butyl ester

4-Boc-morpholine, 98%

Sitagliptin Impurity 134

220199-85-9