3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- Product Name
- 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- CAS No.
- 473923-56-7
- Chemical Name
- 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
- Synonyms
- N-BOC-3-hydroxymethylmorpholine;4-BOC-3-HYDROXYMETHYL-MORPHOLINE;1-N-BOC-2-HYDROXYMETHYL MORPHOLINE;Di-tert-butyl morpholine-3,4-dicarboxylate;tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate;3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate - [B23806];4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB51517209
- Molecular Formula
- C10H19NO4
- Formula Weight
- 217.26
- MOL File
- 473923-56-7.mol
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 320.7±27.0 °C(Predicted)
- Density
- 1.118±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.85±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T135628
- Product name
- tert-Butyl3-(Hydroxymethyl)morpholine-4-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- T135628
- Product name
- tert-Butyl3-(Hydroxymethyl)morpholine-4-carboxylate
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FB140430
- Product name
- tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate
- Packaging
- 1g
- Price
- $160
- Updated
- 2021/12/16
- Product number
- FB140430
- Product name
- tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate
- Packaging
- 2g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FB140430
- Product name
- tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate
- Packaging
- 10g
- Price
- $680
- Updated
- 2021/12/16
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Uses
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER can be used in pharmaceutical synthesis and organic synthesis experiments.
Synthesis
212650-43-6
473923-56-7
Step L (1): synthesis of tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate. To a solution of tetrahydrofuran (THF, 120 mL) of 4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid (4.7 g, 20.35 mmol) was added sequentially Hunig base (6.6 g, 50.875 mmol) and ethyl chloroformate (2.65 g, 24.4 mmol) at 0 °C. The reaction mixture was stirred at 0 °C to room temperature for 1.5 h. Sodium borohydride (NaBH4, 3.1 g, 81.4 mmol) was added. after 15 min, methanol (MeOH, 20 mL) was slowly added. The reaction mixture was continued to be stirred for 1 h at room temperature. Subsequently, THF and MeOH were removed under reduced pressure and diluted by adding ethyl acetate (600 mL). The organic phase was washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and water, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. 3.56 g of the target product tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate was obtained in 81% yield. The product was characterized by 1H NMR (CDCl3, 500 MHz): δ 1.46 (9H, s), 2.03 (1H, br s), 3.17 (1H, m), 3.46 (1H, m), 3.56 (1H, m), 3.72-3.86 (4H, m), 3.91 (1H, d, J = 10 Hz), 3.99 (1H, br s).
References
[1] Patent: US2006/46984, 2006, A1. Location in patent: Page/Page column 25-26
[2] Patent: WO2006/99352, 2006, A1. Location in patent: Page/Page column 35-36
[3] Patent: WO2013/91773, 2013, A1. Location in patent: Page/Page column 130; 131
[4] Patent: US2010/261701, 2010, A1. Location in patent: Page/Page column 144
[5] Patent: WO2008/125570, 2008, A1
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers
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View Lastest Price from 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers
- Product
- 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 473923-56-7
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 95%-98%
- Supply Ability
- 100kg
- Release date
- 2019-09-03