ChemicalBook > CAS DataBase List > 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 473923-56-7
Chemical Name: 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: N-BOC-3-hydroxymethylmorpholine;4-BOC-3-HYDROXYMETHYL-MORPHOLINE;1-N-BOC-2-HYDROXYMETHYL MORPHOLINE;Di-tert-butyl morpholine-3,4-dicarboxylate;tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate;3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate - [B23806];4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester
CBNumber: CB51517209
Molecular Formula: C10H19NO4
Formula Weight: 217.26
MOL File: 473923-56-7.mol

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3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Property

Boiling point:: 320.7±27.0 °C(Predicted)
Density: 1.118±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.85±0.10(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T135628
Product name: tert-Butyl3-(Hydroxymethyl)morpholine-4-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

TRC

Product number: T135628
Product name: tert-Butyl3-(Hydroxymethyl)morpholine-4-carboxylate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140430
Product name: tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate
Packaging: 1g
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140430
Product name: tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate
Packaging: 2g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140430
Product name: tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate
Packaging: 10g
Price: $680
Updated: 2021/12/16

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3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Uses

3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER can be used in pharmaceutical synthesis and organic synthesis experiments.

Synthesis

212650-43-6

473923-56-7

Step L (1): synthesis of tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate. To a solution of tetrahydrofuran (THF, 120 mL) of 4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid (4.7 g, 20.35 mmol) was added sequentially Hunig base (6.6 g, 50.875 mmol) and ethyl chloroformate (2.65 g, 24.4 mmol) at 0 °C. The reaction mixture was stirred at 0 °C to room temperature for 1.5 h. Sodium borohydride (NaBH4, 3.1 g, 81.4 mmol) was added. after 15 min, methanol (MeOH, 20 mL) was slowly added. The reaction mixture was continued to be stirred for 1 h at room temperature. Subsequently, THF and MeOH were removed under reduced pressure and diluted by adding ethyl acetate (600 mL). The organic phase was washed sequentially with saturated sodium bicarbonate (NaHCO3) solution and water, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. 3.56 g of the target product tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate was obtained in 81% yield. The product was characterized by 1H NMR (CDCl3, 500 MHz): δ 1.46 (9H, s), 2.03 (1H, br s), 3.17 (1H, m), 3.46 (1H, m), 3.56 (1H, m), 3.72-3.86 (4H, m), 3.91 (1H, d, J = 10 Hz), 3.99 (1H, br s).

References

[1] Patent: US2006/46984, 2006, A1. Location in patent: Page/Page column 25-26
[2] Patent: WO2006/99352, 2006, A1. Location in patent: Page/Page column 35-36
[3] Patent: WO2013/91773, 2013, A1. Location in patent: Page/Page column 130; 131
[4] Patent: US2010/261701, 2010, A1. Location in patent: Page/Page column 144
[5] Patent: WO2008/125570, 2008, A1

3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER manufacturers

Career Henan Chemical Co

Product: 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER 473923-56-7
Price: US $5.00/KG
Min. Order: 1KG
Purity: 95%-98%
Supply Ability: 100kg
Release date: 2019-09-03

473923-56-7, 3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

TERT-BUTYL 3-(METHOXYMETHYL)AZETIDINE-1-CARBOXYLATE TERT-BUTYL 3-(TOSYLOXYMETHYL)AZETIDINE-1-CARBOXYLATE tert-Butyl 3-(hydroxymethyl)-3-(prop-2-en-1-yl)piperidine-1-carboxylate (R )-6-Hydroxymethyl-morpholin-3-one 6-(HYDROXYMETHYL)MORPHOLIN-3-ONE (S)-6-Hydroxymethyl-morpholin-3-one 4-BOC-2-MORPHOLINECARBALDEHYDE N-Boc-2-(2-hydroxyethyl)morpholine N-Boc-2-(2-Oxo-ethyl)-morpholine N-Boc-3-(2-Oxo-ethyl)-morpholine 2-HYDROXYMETHYL-4-BOC-MORPHOLINE tert-butyl 3-cyanomorpholine-4-carboxylate 3(S)-HYDROXYMETHYL-4-BOCMORPHOLINE tert-Butyl (3R)-3-(hydroxymethyl)morpholine-4-carboxylate tert-butyl 3-(carbamoylamino)pyrrolidine-1-carboxylate TERT-BUTYL 3-(2,2,2-TRIFLUOROACETAMIDO)AZETIDINE-1-CARBOXYLATE 4-Boc-3(R)-morpholinecarboxylic acid MORPHOLINE-3,4-DICARBOXYLIC ACID 4-TERT-BUTYL ESTER

Di-tert-butyl morpholine-3,4-dicarboxylate

3-HYDROXYMETHYL-MORPHOLINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER

1-N-BOC-2-HYDROXYMETHYL MORPHOLINE

tert-Butyl 3-(hydroxymethyl)morpholine-4-carboxylate

4-Morpholinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester

4-BOC-3-HYDROXYMETHYL-MORPHOLINE

N-BOC-3-hydroxymethylmorpholine

tert-butyl 3-(hydroxymethyl)morpholine-4-carboxylate - [B23806]

473923-56-7