5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
- Product Name
- 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
- CAS No.
- 90349-23-8
- Chemical Name
- 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
- Synonyms
- 133800;5677-29-2;SBB006994;ALINDA 7268;AKOS B001272;BAS 16984927;MLS000715307;SMR000275286;AKOS BBS-00002689;VITAS-BB TBB005266
- CBNumber
- CB7443598
- Molecular Formula
- C9H9N3O2
- Formula Weight
- 191.19
- MOL File
- 90349-23-8.mol
5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Property
- Density
- 1.43
- refractive index
- 1.677
- storage temp.
- 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D478938
- Product name
- 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylicAcid
- Packaging
- 2.5g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- FD119842
- Product name
- 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
- Packaging
- 1g
- Price
- $340
- Updated
- 2021/12/16
- Product number
- 5035AC
- Product name
- 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylicacid
- Packaging
- 5g
- Price
- $391
- Updated
- 2021/12/16
- Product number
- 011455
- Product name
- 5,7-Dimethylpyrazolo[5,4-a]pyrimidine-3-carboxylic acid
- Packaging
- 5g
- Price
- $498
- Updated
- 2021/12/16
- Product number
- NUC0001713
- Product name
- 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $510
- Updated
- 2021/12/16
5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production
Uses
5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic Acid is used as a reactant in the synthetic preparation of noninhibitory small molecule chaperones of glucocerebrosidase.
Synthesis
52664-01-4
90349-23-8
General procedure for the synthesis of 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid from ethyl 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate: to a solution of 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate (2.2g, 10.0mmol) in methanol (15mL), was added an aqueous sodium hydroxide solution (5.67 mL, 7.2 M) and the reaction mixture was heated to reflux at 80 °C for 5 hours. After the reaction was completed, it was cooled to room temperature and neutralized with 2M hydrochloric acid. After neutralization, a white solid precipitated from the solution, which was collected by filtration, washed sequentially with water and ether, and dried in vacuum to afford 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid as a white solid (1.3 g, 68% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.21 (s, 1H), 6.84 (s, 1H), 2.65 (s, 3H), 2.53 (s, 3H). Electrospray mass spectrometry (ES-MS) showed m/z 192.00 ([M+H]+).
References
[1] Monatshefte fur Chemie, 2016, vol. 147, # 12, p. 2221 - 2234
[2] Patent: WO2016/73895, 2016, A1. Location in patent: Paragraph 00220
[3] Patent: WO2012/78855, 2012, A1. Location in patent: Page/Page column 17
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 12, p. 5734 - 5748
[5] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 1, p. 214 - 225
5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials
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