ChemicalBook > CAS DataBase List > 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID

5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID

Product Name: 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
CAS No.: 90349-23-8
Chemical Name: 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
Synonyms: 133800;5677-29-2;SBB006994;ALINDA 7268;AKOS B001272;BAS 16984927;MLS000715307;SMR000275286;AKOS BBS-00002689;VITAS-BB TBB005266
CBNumber: CB7443598
Molecular Formula: C9H9N3O2
Formula Weight: 191.19
MOL File: 90349-23-8.mol

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5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Property

Density: 1.43
refractive index: 1.677
storage temp.: 2-8°C
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: D478938
Product name: 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylicAcid
Packaging: 2.5g
Price: $285
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD119842
Product name: 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
Packaging: 1g
Price: $340
Updated: 2021/12/16

AK Scientific

Product number: 5035AC
Product name: 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylicacid
Packaging: 5g
Price: $391
Updated: 2021/12/16

Matrix Scientific

Product number: 011455
Product name: 5,7-Dimethylpyrazolo[5,4-a]pyrimidine-3-carboxylic acid
Packaging: 5g
Price: $498
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001713
Product name: 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 1G
Price: $510
Updated: 2021/12/16

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5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic Acid is used as a reactant in the synthetic preparation of noninhibitory small molecule chaperones of glucocerebrosidase.

Synthesis

52664-01-4

90349-23-8

General procedure for the synthesis of 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid from ethyl 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate: to a solution of 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate (2.2g, 10.0mmol) in methanol (15mL), was added an aqueous sodium hydroxide solution (5.67 mL, 7.2 M) and the reaction mixture was heated to reflux at 80 °C for 5 hours. After the reaction was completed, it was cooled to room temperature and neutralized with 2M hydrochloric acid. After neutralization, a white solid precipitated from the solution, which was collected by filtration, washed sequentially with water and ether, and dried in vacuum to afford 5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid as a white solid (1.3 g, 68% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.21 (s, 1H), 6.84 (s, 1H), 2.65 (s, 3H), 2.53 (s, 3H). Electrospray mass spectrometry (ES-MS) showed m/z 192.00 ([M+H]+).

References

[1] Monatshefte fur Chemie, 2016, vol. 147, # 12, p. 2221 - 2234
[2] Patent: WO2016/73895, 2016, A1. Location in patent: Paragraph 00220
[3] Patent: WO2012/78855, 2012, A1. Location in patent: Page/Page column 17
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 12, p. 5734 - 5748
[5] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 1, p. 214 - 225

5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID Suppliers

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90349-23-8, 5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACIDRelated Search:

TIMTEC-BB SBB006994

ART-CHEM-BB B001272

AKOS B001272

AKOS BBS-00002689

5,7-DIMETHYLPYRAZOLO[5,4-A]PYRIMIDINE-3-CARBOXYLIC ACID

5,7-DIMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID

ALINDA 7268

VITAS-BB TBB005266

pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5,7-dimethyl-

5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid(SALTDATA: FREE)

5,7-dimethyl-3-pyrazolo[1,5-a]pyrimidinecarboxylic acid

5677-29-2

BAS 16984927

MLS000715307

SBB006994

SMR000275286

133800

90349-23-8