1-(4-Nitrophenyl)piperidine
- Product Name
- 1-(4-Nitrophenyl)piperidine
- CAS No.
- 6574-15-8
- Chemical Name
- 1-(4-Nitrophenyl)piperidine
- Synonyms
- AURORA 2061;BUTTPARK 96\57-87;4-CHLORO-2-AMINOPYRIMIDINE;N-(4-NITROPHENYL)PIPERIDINE;1-(4-NITROPHENYL)PIPERIDINE;1-Piperidino-4-nitrobenzene;Piperidine, 1-(4-nitrophenyl)-;6-amino-1,3-dimethyl-5-[2-[[3-(4-methylphenyl)-4-oxo-2-quinazolinyl]thio]-1-oxoethyl]pyrimidine-2,4-dione
- CBNumber
- CB7455858
- Molecular Formula
- C11H14N2O2
- Formula Weight
- 206.24
- MOL File
- 6574-15-8.mol
1-(4-Nitrophenyl)piperidine Property
- Melting point:
- 104-106°C
- Boiling point:
- 363.5±25.0 °C(Predicted)
- Density
- 1.188±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.92±0.20(Predicted)
- CAS DataBase Reference
- 6574-15-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- S539198
- Product name
- 1-(4-NITROPHENYL)PIPERIDINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S539198
- Product name
- 1-(4-NITROPHENYL)PIPERIDINE
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $110
- Updated
- 2024/03/01
- Product number
- N545310
- Product name
- 1-(4-Nitrophenyl)piperidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 071904
- Product name
- 1-(4-Nitrophenyl)piperidine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- 071904
- Product name
- 1-(4-Nitrophenyl)piperidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $23
- Updated
- 2021/12/16
1-(4-Nitrophenyl)piperidine Chemical Properties,Usage,Production
Definition
ChEBI: 1-(4-nitrophenyl)piperidine is a member of piperidines.
Synthesis
110-89-4
100-00-5
6574-15-8
General procedure for the synthesis of 1-(4-nitrophenyl)piperidine from hexahydropyridine and 4-chloronitrobenzene: 4-chloronitrobenzene (100 mg, 0.63 mmol), piperidine (63.86 mg, 0.75 mmol), and SS-Pd (284.5 mg containing 0.01 mmol Pd) were placed in a round-bottomed flask and DMF was added as a solvent. The reaction mixture was heated at 80 °C with magnetic stirring for 6 h. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic layers were combined and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 90:10) to afford 1-(4-nitrophenyl)piperidine (22) as a pale yellow solid (112 mg, 86% yield) with a melting point of 104-105 °C. 1H NMR (300 MHz, CDCl3) δ 8.05-8.09 (m, 2H), 6.76-6.79 (m 2H), 3.43 (m, 4H), 1.68 (m, 6H); 13C NMR (75 MHz, CDCl3) δ 155.28, 137.70, 126.27 (2C), 112.20 (2C), 48.72 (2C), 25.66 (2C), 24.61; high-resolution mass spectrometry (HRMS-ESI) calculated values [M+ H]+ C11H15N2O2 207.2490, measured value 207.2472.
References
[1] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 1, p. 42 - 49
[2] Chemistry Letters, 1987, p. 1187 - 1190
[3] Monatshefte fur Chemie, 2003, vol. 134, # 1, p. 37 - 43
[4] European Journal of Organic Chemistry, 2010, # 19, p. 3621 - 3630
[5] Synthetic Communications, 2000, vol. 30, # 24, p. 4479 - 4488
1-(4-Nitrophenyl)piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-Nitrophenyl)piperidine manufacturers
- Product
- 1-(4-Nitrophenyl)piperidine 6574-15-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2018-12-17