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1-(4-Nitrophenyl)piperidine

Product Name
1-(4-Nitrophenyl)piperidine
CAS No.
6574-15-8
Chemical Name
1-(4-Nitrophenyl)piperidine
Synonyms
AURORA 2061;BUTTPARK 96\57-87;4-CHLORO-2-AMINOPYRIMIDINE;N-(4-NITROPHENYL)PIPERIDINE;1-(4-NITROPHENYL)PIPERIDINE;1-Piperidino-4-nitrobenzene;Piperidine, 1-(4-nitrophenyl)-;6-amino-1,3-dimethyl-5-[2-[[3-(4-methylphenyl)-4-oxo-2-quinazolinyl]thio]-1-oxoethyl]pyrimidine-2,4-dione
CBNumber
CB7455858
Molecular Formula
C11H14N2O2
Formula Weight
206.24
MOL File
6574-15-8.mol
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1-(4-Nitrophenyl)piperidine Property

Melting point:
104-106°C
Boiling point:
363.5±25.0 °C(Predicted)
Density 
1.188±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
1.92±0.20(Predicted)
CAS DataBase Reference
6574-15-8(CAS DataBase Reference)
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Safety

Risk Statements 
20/21/22
Safety Statements 
22-36
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S539198
Product name
1-(4-NITROPHENYL)PIPERIDINE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$113
Updated
2025/07/31
Sigma-Aldrich
Product number
S539198
Product name
1-(4-NITROPHENYL)PIPERIDINE
Purity
AldrichCPR
Packaging
250MG
Price
$110
Updated
2024/03/01
TRC
Product number
N545310
Product name
1-(4-Nitrophenyl)piperidine
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
071904
Product name
1-(4-Nitrophenyl)piperidine
Purity
95+%
Packaging
10g
Price
$52
Updated
2021/12/16
Matrix Scientific
Product number
071904
Product name
1-(4-Nitrophenyl)piperidine
Purity
95+%
Packaging
5g
Price
$23
Updated
2021/12/16
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1-(4-Nitrophenyl)piperidine Chemical Properties,Usage,Production

Definition

ChEBI: 1-(4-nitrophenyl)piperidine is a member of piperidines.

Synthesis

110-89-4

100-00-5

6574-15-8

General procedure for the synthesis of 1-(4-nitrophenyl)piperidine from hexahydropyridine and 4-chloronitrobenzene: 4-chloronitrobenzene (100 mg, 0.63 mmol), piperidine (63.86 mg, 0.75 mmol), and SS-Pd (284.5 mg containing 0.01 mmol Pd) were placed in a round-bottomed flask and DMF was added as a solvent. The reaction mixture was heated at 80 °C with magnetic stirring for 6 h. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic layers were combined and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 90:10) to afford 1-(4-nitrophenyl)piperidine (22) as a pale yellow solid (112 mg, 86% yield) with a melting point of 104-105 °C. 1H NMR (300 MHz, CDCl3) δ 8.05-8.09 (m, 2H), 6.76-6.79 (m 2H), 3.43 (m, 4H), 1.68 (m, 6H); 13C NMR (75 MHz, CDCl3) δ 155.28, 137.70, 126.27 (2C), 112.20 (2C), 48.72 (2C), 25.66 (2C), 24.61; high-resolution mass spectrometry (HRMS-ESI) calculated values [M+ H]+ C11H15N2O2 207.2490, measured value 207.2472.

References

[1] Bulletin of the Chemical Society of Japan, 1991, vol. 64, # 1, p. 42 - 49
[2] Chemistry Letters, 1987, p. 1187 - 1190
[3] Monatshefte fur Chemie, 2003, vol. 134, # 1, p. 37 - 43
[4] European Journal of Organic Chemistry, 2010, # 19, p. 3621 - 3630
[5] Synthetic Communications, 2000, vol. 30, # 24, p. 4479 - 4488

1-(4-Nitrophenyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-Nitrophenyl)piperidine Suppliers

Austria 1 Belgium 1 China 48 France 1 Germany 2 India 4 Russia 1 South Korea 1 The Netherlands 1 United Kingdom 7 United States 20 Global 87
Brunschwig chemie
Tel
--
Fax
--
Email
brunschwig@brunschwig.nl
Country
The Netherlands
ProdList
4996
Advantage
67
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View Lastest Price from 1-(4-Nitrophenyl)piperidine manufacturers

Career Henan Chemical Co
Product
1-(4-Nitrophenyl)piperidine 6574-15-8
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2018-12-17

6574-15-8, 1-(4-Nitrophenyl)piperidineRelated Search:

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  • BUTTPARK 96\57-87
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  • 1-(4-NITROPHENYL)PIPERIDINE
  • N-(4-NITROPHENYL)PIPERIDINE
  • 4-CHLORO-2-AMINOPYRIMIDINE
  • 6-amino-1,3-dimethyl-5-[2-[[3-(4-methylphenyl)-4-oxo-2-quinazolinyl]thio]-1-oxoethyl]pyrimidine-2,4-dione
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  • 6574-15-8
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  • CHIRAL CHEMICALS
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