1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
Application- Product Name
- 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
- CAS No.
- 305381-67-3
- Chemical Name
- 1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID
- Synonyms
- 1,2,3-Propanetriol,1,8-diacetate;1-methylbenzotriazole-5-carboxylic acid;1-METHYL-1H-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1H-Benzotriazole-5-carboxylicacid, 1-Methyl-;1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID;1-methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid;1-methyl-1H-1,2,3-benzotriazole-5-carboxylic acid - [M86437]
- CBNumber
- CB7459139
- Molecular Formula
- C8H7N3O2
- Formula Weight
- 177.16
- MOL File
- 305381-67-3.mol
1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Property
- Melting point:
- 250 °C
- Boiling point:
- 432.4±18.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.51±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- M335260
- Product name
- 1-Methylbenzotriazole-5-carboxylicacid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H21-1-K9
- Product name
- 1-Methyl-1H-benzotriazole-5-carboxylic acid
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Y8616
- Product name
- 1-Methyl-1H-benzotriazole-5-carboxylicacid
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- AS148048
- Product name
- 1-Methyl-1H-benzo[d][1,2,3]triazole-5-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
- Product number
- 4H21-1-K9
- Product name
- 1-Methyl-1H-benzotriazole-5-carboxylic acid
- Packaging
- 1g
- Price
- $311
- Updated
- 2021/12/16
1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Application
1-Methyl-1,2,3-benzotriazole-5-carboxylic acid is an organic intermediate that can be prepared from 4-amino-3-nitrobenzoic acid as a raw material. 4-amino-3-nitrobenzoic acid is then prepared, followed by methylation to obtain methyl 4-methylamino-3-nitrobenzoate, reduction of the nitro group to obtain methyl 4-methylamino-3-aminobenzoate, cyclization to obtain methyl 4-methylamino-3-aminobenzoate, and finally hydrolysis of the methyl ester to obtain 1-methyl-1,2,3-benzotriazole-5-carboxylic acid.
Synthesis
The synthesis of 1-Methyl-1H-1,2,3-benzotriazole-5-carboxylic acid is carried out as follows:
To a stirred suspension of the diamine 280 (1.08g; 6.48mmol) (or any other oarylenediamine) in water (25 mL) at 0°C, concentrated HCl (5.4 mL) was added drop wise followed by slow addition of a solution of NaNO2 (643mg; 9.3mmol) in water (10 mL). The reaction mixture was stirred at 0°C for 2h and then was allowed to warm up to 10°C over 4h; neutralized with a solution of KOH (5.6 g) in water (30mL) (final pH = 6); concentrated and purified by preparative HPLC in reverse phase mode (column aquasil C-18, elution 5% to 95% MeOH in water), to afford the title compound 284 (211 mg; 18% yield). 1-Methyl-1H-benzo[d][1,2,3]triazole-5-carboxylic acid (284), yield (211 mg; 18%). 1HNMR: (400.2 MHz, DMSO) δ (ppm): 8.35 (s; 1H); 8.08 (dd, J= 1.4, 8.6 Hz; 1H); 7.75 (d, J= 1.4 Hz; 1H); 4.03 (s, 3H). MS: calc: 177.1; found: 178.1 (M+H).
1-METHYL-1H-1,2,3-BENZOTRIAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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