ChemicalBook > CAS DataBase List > (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
- Product Name
- (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
- CAS No.
- 745055-86-1
- Chemical Name
- (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
- Synonyms
- UBP 296;(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
- CBNumber
- CB7460159
- Molecular Formula
- C15H15N3O6
- Formula Weight
- 333.3
- MOL File
- Mol file
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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Property
- Melting point:
- 190.8-191.2 °C (decomp)(Solv: water (7732-18-5))
- Boiling point:
- 603.0±65.0 °C(Predicted)
- Density
- 1.525±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- <3.33mg/ml in 1eq. NaOH; <3.33mg/ml in DMSO
- pka
- 2.12±0.10(Predicted)
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N-Bromosuccinimide Price
Tocris
- Product number
- 2078
- Product name
- UBP296
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $233
- Updated
- 2021/12/16
Tocris
- Product number
- 2078
- Product name
- UBP296
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $982
- Updated
- 2021/12/16
TRC
- Product number
- U103515
- Product name
- UBP296
- Packaging
- 10mg
- Price
- $215
- Updated
- 2021/12/16
Usbiological
- Product number
- 257005
- Product name
- UBP 296
- Packaging
- 10mg
- Price
- $495
- Updated
- 2021/12/16
TRC
- Product number
- U103515
- Product name
- UBP296
- Packaging
- 50mg
- Price
- $905
- Updated
- 2021/12/16
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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Chemical Properties,Usage,Production
Uses
UBP 296 is a novel, potent and selective kainate receptor antagonist.
Definition
ChEBI: 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid is an alpha-amino acid.
Biological Activity
Selective and potent GluR5-subunit containing kainate receptor antagonist (apparent K D = 1.09 mM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.
storage
Store at RT
(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Suppliers
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