ChemicalBook > CAS DataBase List > (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE

Product Name
(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
CAS No.
745055-86-1
Chemical Name
(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
Synonyms
UBP 296;(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
CBNumber
CB7460159
Molecular Formula
C15H15N3O6
Formula Weight
333.3
MOL File
Mol file
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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Property

Melting point:
190.8-191.2 °C (decomp)(Solv: water (7732-18-5))
Boiling point:
603.0±65.0 °C(Predicted)
Density 
1.525±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
<3.33mg/ml in 1eq. NaOH; <3.33mg/ml in DMSO
pka
2.12±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
2078
Product name
UBP296
Purity
≥98%(HPLC)
Packaging
10
Price
$233
Updated
2021/12/16
Tocris
Product number
2078
Product name
UBP296
Purity
≥98%(HPLC)
Packaging
50
Price
$982
Updated
2021/12/16
TRC
Product number
U103515
Product name
UBP296
Packaging
10mg
Price
$215
Updated
2021/12/16
Usbiological
Product number
257005
Product name
UBP 296
Packaging
10mg
Price
$495
Updated
2021/12/16
TRC
Product number
U103515
Product name
UBP296
Packaging
50mg
Price
$905
Updated
2021/12/16
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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Chemical Properties,Usage,Production

Uses

UBP 296 is a novel, potent and selective kainate receptor antagonist.

Definition

ChEBI: 2-[[3-(2-amino-2-carboxyethyl)-2,6-dioxo-1-pyrimidinyl]methyl]benzoic acid is an alpha-amino acid.

Biological Activity

Selective and potent GluR5-subunit containing kainate receptor antagonist (apparent K D = 1.09 mM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibres.

storage

Store at RT

(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE Suppliers

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745055-86-1, (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONERelated Search:


  • (RS)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE
  • UBP 296
  • 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxyphenyl)methyl]-3,4-dihydro-2,4-dioxo-
  • 745055-86-1
  • Glutamate receptor