(S)-(+)-2-(ANILINOMETHYL)PYRROLIDINE Property

Melting point:

19°C

Boiling point:

111-112 °C/0.55 mmHg (lit.)

Density 

1.046 g/mL at 25 °C (lit.)

refractive index 

1.5750

Flash point:

>230 °F

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

sol ether, THF.

pka

10.52±0.10(Predicted)

form 

clear liquid

color 

Colorless to Yellow to Green

optical activity

[α]20/D +19°, c = 1 in ethanol

Sensitive 

Air Sensitive

BRN 

472065

CAS DataBase Reference

64030-44-0(CAS DataBase Reference)

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 3267 8/PG 2

WGK Germany 

3

HazardClass 

8

PackingGroup 

III

HS Code 

29339900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

(S)-(+)-2-(ANILINOMETHYL)PYRROLIDINE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless viscous liquid

Synthesis

(S)-2-(Anilinomethyl)pyrrolidine is prepared by the reaction of (S)-N-(benzyloxycarbonyl)proline with ethyl  chloroformate and N-methylmorpholine, aniline, hydrogenolysis with Pd/C, and reduction with LiAlH4 affords the title compound in 59% overall yield.