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ZOTEPINE

Product Name
ZOTEPINE
CAS No.
26615-21-4
Chemical Name
ZOTEPINE
Synonyms
Setous;lodopin;zotepina;ZOTEPINE;Majorpin;Etoxazole Impurity 9;8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin;f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(;2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine;2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
CBNumber
CB7461848
Molecular Formula
C18H18ClNOS
Formula Weight
331.86
MOL File
26615-21-4.mol
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ZOTEPINE Property

Melting point:
90-91°
Boiling point:
478.4±45.0 °C(Predicted)
Density 
1.0675 (rough estimate)
refractive index 
1.6100 (estimate)
storage temp. 
Store at RT
solubility 
DMSO: ≥20mg/mL
pka
8.72±0.28(Predicted)
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
T
Risk Statements 
25-50/53
Safety Statements 
45-60-61
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Toxicity
LD50 in male mice, rats (mg/kg): 108, 458 orally; 43.3, 39.7 i.v.; 40.0, 97.0 i.p.; 84.9, 2080 s.c. (Fukuhara)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Z0877
Product name
Zotepine
Purity
>98% (HPLC)
Packaging
10mg
Price
$88.8
Updated
2024/03/01
Sigma-Aldrich
Product number
Z0877
Product name
Zotepine
Purity
>98% (HPLC)
Packaging
50mg
Price
$269
Updated
2024/03/01
Cayman Chemical
Product number
23909
Product name
Zotepine
Purity
≥98%
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
23909
Product name
Zotepine
Purity
≥98%
Packaging
25mg
Price
$142
Updated
2024/03/01
Cayman Chemical
Product number
23909
Product name
Zotepine
Purity
≥98%
Packaging
50mg
Price
$270
Updated
2024/03/01
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ZOTEPINE Chemical Properties,Usage,Production

Chemical Properties

White to off white crystalline powder

Originator

Lodopin,Fujisawa Pharmaceutical,Japan,1982

Uses

antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist

Definition

ChEBI: Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.

Manufacturing Process

A suspension of 30 g of sodium hydride in benzene (30 ml) was added dropwise to 52 g of 8-chlorodibenzo[b,f]thiepin-10(11H)-one dissolved in dimethylformamide (800 ml), and the mixture was heated at 100°C for 2 hours. To this, there were added 68 g of 2-dimethylaminoethyl chloride, and the mixture was heated at 60°C for 39 hours. The reaction mixture, after cooled, was poured into ice-water, and the solution was extracted with ethyl acetate. The ethyl acetate layer, after washed with water, was extracted with 10% hydrochloric acid, when oil was precipitated. The aqueous layer, in which oil was precipitated, was washed with ether, made neutral with concentrated sodium hydroxide solution and then extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give oil, which was allowed to stand to provide solid. The solid was washed with petroleum ether and recrystallized from cyclohexane to yield 42.5 g of 8-chloro-10-(2-dimethylaminoethyl)-oxydibenzo[b,f]thiepin as crystals, melting point 90°C to 91°C. Maleate as colorless needle, melting point 204°C to 204.5°C.

Therapeutic Function

Tranquilizer

ZOTEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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ZOTEPINE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
Shanghai HuanChuan Industry Co.,Ltd.
Tel
021-61478794
Fax
021-61478794
Email
sales@hcshhai.com
Country
China
ProdList
9793
Advantage
50
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View Lastest Price from ZOTEPINE manufacturers

Zhejiang J&C Biological Technology Co.,Limited
Product
ZOTEPINE 26615-21-4
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-17

26615-21-4, ZOTEPINERelated Search:


  • ZOTEPINE
  • 2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-n,n-dimethylethanamine
  • 2-chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin
  • 2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
  • 2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine
  • 2-[(3-chloro-5-benzo[b][1]benzothiepinyl)oxy]-N,N-dimethylethanamine
  • f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(
  • lodopin
  • zotepina
  • 8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin
  • Majorpin
  • N,N-Dimethyl-2-(2-chlorodibenzo[b,f]thiepin-11-yloxy)ethylamine
  • Setous
  • 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxyethyl-dimethyl-amine
  • 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethylethanamine
  • 2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethyl-ethanamine
  • 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
  • Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-
  • ZotepineQ: What is Zotepine Q: What is the CAS Number of Zotepine Q: What is the storage condition of Zotepine Q: What are the applications of Zotepine
  • 5-HT Receptor,antipsychotic,antidepressive,Serotonin Receptor,Inhibitor,anxiolytic,inhibit,5-hydroxytryptamine Receptor,Zotepine,Adrenergic Receptor,Beta Receptor,Histamine Receptor,Dopamine Receptor
  • Etoxazole Impurity 9
  • 26615-21-4
  • Pharmaceutical intermediate