ZOTEPINE
- Product Name
- ZOTEPINE
- CAS No.
- 26615-21-4
- Chemical Name
- ZOTEPINE
- Synonyms
- Setous;lodopin;zotepina;ZOTEPINE;Majorpin;Etoxazole Impurity 9;8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin;f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(;2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine;2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
- CBNumber
- CB7461848
- Molecular Formula
- C18H18ClNOS
- Formula Weight
- 331.86
- MOL File
- 26615-21-4.mol
ZOTEPINE Property
- Melting point:
- 90-91°
- Boiling point:
- 478.4±45.0 °C(Predicted)
- Density
- 1.0675 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- Store at RT
- solubility
- DMSO: ≥20mg/mL
- pka
- 8.72±0.28(Predicted)
- form
- powder
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- Z0877
- Product name
- Zotepine
- Purity
- >98% (HPLC)
- Packaging
- 10mg
- Price
- $88.8
- Updated
- 2024/03/01
- Product number
- Z0877
- Product name
- Zotepine
- Purity
- >98% (HPLC)
- Packaging
- 50mg
- Price
- $269
- Updated
- 2024/03/01
- Product number
- 23909
- Product name
- Zotepine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 23909
- Product name
- Zotepine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 23909
- Product name
- Zotepine
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $270
- Updated
- 2024/03/01
ZOTEPINE Chemical Properties,Usage,Production
Chemical Properties
White to off white crystalline powder
Originator
Lodopin,Fujisawa Pharmaceutical,Japan,1982
Uses
antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist
Definition
ChEBI: Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.
Manufacturing Process
A suspension of 30 g of sodium hydride in benzene (30 ml) was added dropwise to 52 g of 8-chlorodibenzo[b,f]thiepin-10(11H)-one dissolved in dimethylformamide (800 ml), and the mixture was heated at 100°C for 2 hours. To this, there were added 68 g of 2-dimethylaminoethyl chloride, and the mixture was heated at 60°C for 39 hours. The reaction mixture, after cooled, was poured into ice-water, and the solution was extracted with ethyl acetate. The ethyl acetate layer, after washed with water, was extracted with 10% hydrochloric acid, when oil was precipitated. The aqueous layer, in which oil was precipitated, was washed with ether, made neutral with concentrated sodium hydroxide solution and then extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give oil, which was allowed to stand to provide solid. The solid was washed with petroleum ether and recrystallized from cyclohexane to yield 42.5 g of 8-chloro-10-(2-dimethylaminoethyl)-oxydibenzo[b,f]thiepin as crystals, melting point 90°C to 91°C. Maleate as colorless needle, melting point 204°C to 204.5°C.
Therapeutic Function
Tranquilizer
ZOTEPINE Preparation Products And Raw materials
Raw materials
Preparation Products
ZOTEPINE Suppliers
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View Lastest Price from ZOTEPINE manufacturers
- Product
- ZOTEPINE 26615-21-4
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-17