ZOTEPINE

ChemicalBook > CAS DataBase List > ZOTEPINE

Product Name: ZOTEPINE
CAS No.: 26615-21-4
Chemical Name: ZOTEPINE
Synonyms: Setous;lodopin;zotepina;ZOTEPINE;Majorpin;Etoxazole Impurity 9;8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin;f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(;2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine;2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin
CBNumber: CB7461848
Molecular Formula: C18H18ClNOS
Formula Weight: 331.86
MOL File: 26615-21-4.mol

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ZOTEPINE Property

Melting point:: 90-91°
Boiling point:: 478.4±45.0 °C(Predicted)
Density: 1.0675 (rough estimate)
refractive index: 1.6100 (estimate)
storage temp.: Store at RT
solubility: DMSO: ≥20mg/mL
pka: 8.72±0.28(Predicted)
form: powder
color: white to off-white

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Safety

Hazard Codes: T
Risk Statements: 25-50/53
Safety Statements: 45-60-61
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
Toxicity: LD50 in male mice, rats (mg/kg): 108, 458 orally; 43.3, 39.7 i.v.; 40.0, 97.0 i.p.; 84.9, 2080 s.c. (Fukuhara)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Z0877
Product name: Zotepine
Purity: >98% (HPLC)
Packaging: 10mg
Price: $88.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: Z0877
Product name: Zotepine
Purity: >98% (HPLC)
Packaging: 50mg
Price: $269
Updated: 2024/03/01

Cayman Chemical

Product number: 23909
Product name: Zotepine
Purity: ≥98%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 23909
Product name: Zotepine
Purity: ≥98%
Packaging: 25mg
Price: $142
Updated: 2024/03/01

Cayman Chemical

Product number: 23909
Product name: Zotepine
Purity: ≥98%
Packaging: 50mg
Price: $270
Updated: 2024/03/01

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ZOTEPINE Chemical Properties,Usage,Production

Chemical Properties

White to off white crystalline powder

Originator

Lodopin,Fujisawa Pharmaceutical,Japan,1982

Uses

antipsychotic;Dopamine D2/serotonin 5-HT2 antagonist

Definition

ChEBI: Zotepine is a dibenzothiepine and a tertiary amino compound. It has a role as an alpha-adrenergic drug, a serotonergic drug and a second generation antipsychotic.

Manufacturing Process

A suspension of 30 g of sodium hydride in benzene (30 ml) was added dropwise to 52 g of 8-chlorodibenzo[b,f]thiepin-10(11H)-one dissolved in dimethylformamide (800 ml), and the mixture was heated at 100°C for 2 hours. To this, there were added 68 g of 2-dimethylaminoethyl chloride, and the mixture was heated at 60°C for 39 hours. The reaction mixture, after cooled, was poured into ice-water, and the solution was extracted with ethyl acetate. The ethyl acetate layer, after washed with water, was extracted with 10% hydrochloric acid, when oil was precipitated. The aqueous layer, in which oil was precipitated, was washed with ether, made neutral with concentrated sodium hydroxide solution and then extracted with ethyl acetate. The ethyl acetate layer was washed with water, dried over magnesium sulfate, and concentrated to give oil, which was allowed to stand to provide solid. The solid was washed with petroleum ether and recrystallized from cyclohexane to yield 42.5 g of 8-chloro-10-(2-dimethylaminoethyl)-oxydibenzo[b,f]thiepin as crystals, melting point 90°C to 91°C. Maleate as colorless needle, melting point 204°C to 204.5°C.

Therapeutic Function

Tranquilizer

ZOTEPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ZOTEPINE manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: ZOTEPINE 26615-21-4
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

26615-21-4, ZOTEPINERelated Search:

N,N-Dimethylethylamine ZOTEPINE

ZOTEPINE

2-((8-chlorodibenzo(b,f)thiepin-10-yl)oxy)-n,n-dimethylethanamine

2-chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-thiepin

2-chloro-11-(2-(dimethylamino)ethoxy)dibenzo(b,f)thiepin

2-chloro-11-(2-dimethylaminoethoxy)-dibenzo(b,f)thiepine

2-[(3-chloro-5-benzo[b][1]benzothiepinyl)oxy]-N,N-dimethylethanamine

f)thiepin,2-chloro-11-(2-(dimethylamino)ethoxy)-dibenzo(

lodopin

zotepina

8-Chloro-10-[2-(dimethylamino)ethoxy]dibenzo[b,f]thiepin

Majorpin

N,N-Dimethyl-2-(2-chlorodibenzo[b,f]thiepin-11-yloxy)ethylamine

Setous

2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxyethyl-dimethyl-amine

2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethylethanamine

2-(8-chlorobenzo[b][1]benzothiepin-6-yl)oxy-N,N-dimethyl-ethanamine

2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine

Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-

ZotepineQ: What is Zotepine Q: What is the CAS Number of Zotepine Q: What is the storage condition of Zotepine Q: What are the applications of Zotepine

5-HT Receptor,antipsychotic,antidepressive,Serotonin Receptor,Inhibitor,anxiolytic,inhibit,5-hydroxytryptamine Receptor,Zotepine,Adrenergic Receptor,Beta Receptor,Histamine Receptor,Dopamine Receptor

Etoxazole Impurity 9

26615-21-4

Pharmaceutical intermediate