1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- Product Name
- 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- CAS No.
- 941987-60-6
- Chemical Name
- 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- Synonyms
- H-151;H 151 NEW;H 151 (H-151);STING inhibitor;STING antagonist;H-151 (STING inhibitor);1-(4-Ethylphenyl)-3-(3-indolyl)urea;N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea;H151;H-151;H-151;H-151;STING ANTAGONIST;1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
- CBNumber
- CB74635441
- Molecular Formula
- C17H17N3O
- Formula Weight
- 279.34
- MOL File
- 941987-60-6.mol
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Property
- Boiling point:
- 399.9±25.0 °C(Predicted)
- Density
- 1.298±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (25 mg/ml)
- pka
- 14.96±0.70(Predicted)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25857
- Product name
- H-151
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 25857
- Product name
- H-151
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 25857
- Product name
- H-151
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $537
- Updated
- 2024/03/01
- Product number
- 25857
- Product name
- H-151
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $952
- Updated
- 2024/03/01
- Product number
- 6675
- Product name
- H151
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $718
- Updated
- 2021/12/16
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Chemical Properties,Usage,Production
Description
H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.
Uses
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea (cas# 941987-60-6) is a useful research chemical. It is used in biological studies in the enhancement of transgene expression by beta-catenin inhibitor iCRT14.
storage
Store at +4°C
References
1) Haag et al. (2018), Targeting STING with covalent small-molecule inhibitors; Nature 559 269 2) Lee et al. (2019), STING restricts oHSV Replication and Spread in Resistant MPNSYs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation; Mol. Ther. Oncolytics 15 91 [FOCUS Citation]
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Preparation Products And Raw materials
Raw materials
Preparation Products
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