1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

Product Name: 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CAS No.: 941987-60-6
Chemical Name: 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
Synonyms: H-151;H 151 NEW;H 151 (H-151);STING inhibitor;STING antagonist;H-151, 10 mM in DMSO;H-151 (STING inhibitor);H-151 10mM*1ml in DMSO;STING Antagonist (H-151);1-(4-Ethylphenyl)-3-(3-indolyl)urea
CBNumber: CB74635441
Molecular Formula: C17H17N3O
Formula Weight: 279.34
MOL File: 941987-60-6.mol

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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Property

Boiling point:: 399.9±25.0 °C(Predicted)
Density: 1.298±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (25 mg/ml)
pka: 14.96±0.70(Predicted)
form: solid
color: Off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChIKey: UJZDIKVQFMCLBE-UHFFFAOYSA-N
SMILES: N(C1=CC=C(CC)C=C1)C(NC1C2=C(NC=1)C=CC=C2)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2437
Product name: H-151
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $105
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2437
Product name: H-151
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $406
Updated: 2025/07/31

Cayman Chemical

Product number: 25857
Product name: H-151
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 25857
Product name: H-151
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 25857
Product name: H-151
Purity: ≥98%
Packaging: 50mg
Price: $537
Updated: 2024/03/01

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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Chemical Properties,Usage,Production

Description

H-151 (941987-60-6) is an inhibitor of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduced systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

Uses

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea (cas# 941987-60-6) is a useful research chemical. It is used in biological studies in the enhancement of transgene expression by beta-catenin inhibitor iCRT14.

in vivo

H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice^[1].
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1^/ mice that expressed a bioluminescent IFNβ reporter^[1].
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice^[1].

storage

Store at +4°C

References

[1] SIMONE M. HAAG. Targeting STING with covalent small-molecule inhibitors[J]. Nature, 2018, 559 7713: 269-273. DOI:10.1038/s41586-018-0287-8
[2] JOEL LEE K C M Ghonime. STING Restricts oHSV Replication and Spread in Resistant MPNSTs but Is Dispensable for Basal IFN-Stimulated Gene Upregulation[J]. Molecular Therapy Oncolytics, 2019, 22 1: 91-100. DOI:10.1016/j.omto.2019.09.001

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea Suppliers

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941987-60-6, 1-(4-ethylphenyl)-3-(1H-indol-3-yl)ureaRelated Search:

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1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

H151;H-151;H-151;H-151;STING ANTAGONIST

STING antagonist

N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea

H-151

H 151 NEW

Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-

STING inhibitor

H 151 (H-151)

ERIS,phosphorylation,Stimulator of Interferon Genes,H-151,palmitoylatio,TMEM173,MPYS,inhibit,autoinflammatory,TBK1,STING,Inhibitor,MITA,H151,H 151

H-151 (STING inhibitor)

1-(4-Ethylphenyl)-3-(3-indolyl)urea

STING Antagonist (H-151)

H-151, 10 mM in DMSO

H-151 10mM*1ml in DMSO

941987-60-6