BOC-(RS)-3-AMINO-1,2-PROPANEDIOL
- Product Name
- BOC-(RS)-3-AMINO-1,2-PROPANEDIOL
- CAS No.
- 137618-48-5
- Chemical Name
- BOC-(RS)-3-AMINO-1,2-PROPANEDIOL
- Synonyms
- tert-Butyl (2,3-dihydroxypropyl)carbaMate;N-Boc-3-amino-1,2-propanediol;TERT-BUTYL N-(2,3-DIHYDROXYPROPYL)CARBAMATE;BOC-(RS)-3-AMINO-1;-Boc-amino-1,2-propanediol;3-Boc-amino-1,2-propanediol;BOC-(RS)-3-AMINO-1,2-PROPANEDIOL;tert-Butyl (2,3-dihydroxypropyl);ert-butylN-(2,3-dihydroxypropyl)carbamate;tert-Butyl N-(2,3-dihydroxypropyl)carbamate 97%
- CBNumber
- CB7465644
- Molecular Formula
- C8H17NO4
- Formula Weight
- 191.22
- MOL File
- 137618-48-5.mol
BOC-(RS)-3-AMINO-1,2-PROPANEDIOL Property
- Melting point:
- 60-63 °C (lit.)
- Boiling point:
- 361.6±32.0 °C(Predicted)
- Density
- 1.136±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- 12.19±0.46(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H17NO4/c1-8(2,3)13-7(12)9-4-6(11)5-10/h6,10-11H,4-5H2,1-3H3,(H,9,12)
- InChIKey
- OWAMQHJPVUGZSB-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCC(O)CO
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 471747
- Product name
- tert-Butyl N-(2,3-dihydroxypropyl)carbamate
- Purity
- 97%
- Packaging
- 25g
- Price
- $152.95
- Updated
- 2025/07/31
- Product number
- B808005
- Product name
- 1-[(tert-Butyloxycarbonyl)amino]propane-2,3-diol
- Packaging
- 10g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FB140641
- Product name
- tert-Butyl (2,3-dihydroxypropyl)carbamate
- Packaging
- 5G
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 6601AA
- Product name
- tert-Butyl(2,3-dihydroxypropyl)carbamate
- Packaging
- 5g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- FB140641
- Product name
- tert-Butyl (2,3-dihydroxypropyl)carbamate
- Packaging
- 10g
- Price
- $162.5
- Updated
- 2021/12/16
BOC-(RS)-3-AMINO-1,2-PROPANEDIOL Chemical Properties,Usage,Production
Uses
tert-Butyl N-(2,3-dihydroxypropyl)carbamate may be used in the preparation of isobaric mix solution for use in post-column infusion experiment during single-stage orbitrap mass spectrometric analysis.
General Description
tert-Butyl N-(2,3-dihydroxypropyl)carbamate is a protected amine.
Synthesis
616-30-8
24424-99-5
137618-48-5
GENERAL STEPS: 3-Amino-1,2-propanediol (3 g, 32.93 mmol, 1.0 eq.) was dissolved in a mixture of 20 mL of tert-butanol and 20 mL of 1 M NaOH. A 20 mL solution of tert-butanol containing di-tert-butyl dicarbonate (7.19 g, 32.93 mmol, 1.0 eq.) was slowly added under ice bath cooling conditions. The reaction mixture was stirred at room temperature for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction solution was concentrated under reduced pressure in a 50 °C water bath. Subsequently, the reaction mixture was neutralized with 1 M HCl solution. The neutralized solution was subjected to liquid-liquid extraction with ethyl acetate and water, which was repeated three times. The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The dried organic phase was concentrated under reduced pressure in a water bath at 40 °C to give 6.3 g of tert-butyl N-(2,3-dihydroxypropyl)carbamate (yield: quantitative). The structure of the product was confirmed by 1H-NMR: 1H-NMR (500 MHz, CDCl3) δ 1.45 (9H, s), 2.68-2.71 (1H, br), 2.75-2.81 (1H, br), 3.20 (2H, dd), 3.63 (2H, dd), 3.71 (1H, m), 4.91 (1H, br).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 2, p. 623 - 627
[2] Patent: US2016/151506, 2016, A1. Location in patent: Paragraph 0308-0312
[3] Canadian Journal of Chemistry, 1997, vol. 75, # 7, p. 942 - 948
[4] Patent: US2006/69156, 2006, A1. Location in patent: Page/Page column 26
[5] Patent: US2006/154984, 2006, A1. Location in patent: Page/Page column 41
BOC-(RS)-3-AMINO-1,2-PROPANEDIOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-(RS)-3-AMINO-1,2-PROPANEDIOL manufacturers
- Product
- BOC-(RS)-3-AMINO-1,2-PROPANEDIOL 137618-48-5
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2019-12-25