N-Acetylpuromycin
- Product Name
- N-Acetylpuromycin
- CAS No.
- 22852-13-7
- Chemical Name
- N-Acetylpuromycin
- Synonyms
- N-Acetylpuromycin;3'-[(N-acetyl-O-methyl-L-tyrosyl)-amino]-N6,N6-dimethyl-3'-deoxy-adenosine;3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine;Adenosine, 3'-[[(2S)-2-(acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-
- CBNumber
- CB74666508
- Molecular Formula
- C24H31N7O6
- Formula Weight
- 513.55
- MOL File
- 22852-13-7.mol
N-Acetylpuromycin Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 70 mg/ml) or in DMF (up to 55 mg/ml)
- form
- solid
- pka
- 12.98±0.70(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 2 months.
N-Bromosuccinimide Price
- Product number
- 25335
- Product name
- N-Acetylpuromycin
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 25335
- Product name
- N-Acetylpuromycin
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 25335
- Product name
- N-Acetylpuromycin
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
- Product number
- 25335
- Product name
- N-Acetylpuromycin
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $442
- Updated
- 2024/03/01
- Product number
- 5679
- Product name
- N-Acetylpuromycin
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $195
- Updated
- 2021/12/16
N-Acetylpuromycin Chemical Properties,Usage,Production
Description
N-Acetylpuromycin is a non-ribotoxic form of the antibiotic puromycin that is formed in puromycin-resistant S. alboniger that endogenously express puromycin-acetyltransferase. In AD293(Pr) cells that express puromycin-N-acetyltransferase, the enzyme responsible for the biosynthesis of N-acetylpuromycin, puromycin application induces downregulation of the negative regulators of TGF-β signalling SnoN and Ski without activating MAPK or inhibition of protein synthesis.
Uses
N-Acetylpurinomycin downregulates SnoN and Ski protein expression and promotes TGF-β signaling, independently of MAPK activation.
storage
Store at -20°C
References
[1] JACQUELINE HERNÁNDEZ-DAMIÁN . Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals[J]. Biochimica et biophysica acta. General subjects, 2013, 1830 11: Pages 5049-5058. DOI:10.1016/j.bbagen.2013.07.006
N-Acetylpuromycin Preparation Products And Raw materials
Raw materials
Preparation Products
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