ChemicalBook > CAS DataBase List > (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE

Product Name
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
CAS No.
87173-97-5
Chemical Name
(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
Synonyms
U-62066;U-62066 (mesylate);SPIRADOLINE MESYLATE;rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide,monomethanesulfonate;(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
CBNumber
CB7468579
Molecular Formula
C23H34Cl2N2O5S
Formula Weight
521.49
MOL File
87173-97-5.mol
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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Property

storage temp. 
2-8°C
solubility 
H2O: 14 mg/mL
form 
solid
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
25072
Product name
U-62066 (mesylate)
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
25072
Product name
U-62066 (mesylate)
Purity
≥98%
Packaging
5mg
Price
$356
Updated
2024/03/01
AK Scientific
Product number
3362CA
Product name
Spiradolinemesylate
Packaging
5mg
Price
$495
Updated
2021/12/16
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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Chemical Properties,Usage,Production

Uses

Analgesic.

in vivo

Spiradoline mesylate (U-62066; 0.1-0.4 mg/kg; subcutaneous injection; once; Sprague-Dawley rats) treatment dose-dependently reduces social behaviors in non-stressed adults, producing social avoidance at the highest dose tested, while younger animals displays reduced sensitivity to this socially suppressing effect of Spiradoline mesylate. In stressed animals, the socially suppressing effects of the Spiradoline mesylate are blunted at all ages, with juveniles and adolescents exhibiting increased social preference in response to certain doses of U-62066[1].

Animal Model:Juvenile, adolescent and adult Sprague-Dawley male and female rats exposured to repeated restraint[1]
Dosage:0.1 mg/kg, 0.2 mg/kg, 0.3 mg/kg, and 0.4?mg/kg
Administration:Subcutaneous injection; once
Result:Dose-dependently reduced social behaviors in non-stressed adults, producing social avoidance at the highest dose tested.

(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE Suppliers

China 5 Switzerland 1 United States 3 Global 9
SIGMA-RBI
Tel
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Country
Switzerland
ProdList
6896
Advantage
91

87173-97-5, (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATERelated Search:

(1R,2R)-N,N'-Dimethyl-1,2-cyclohexanediamine 1,2-Diaminocyclohexane (1R,2R)-(-)-1,2-Diaminocyclohexane (R)-(+)-1,2-Diaminopropane dihydrochloride 4-Methylcyclohexyl amine trans-4-Aminocyclohexanol hydrochloride trans-4-(Dimethylamino)cyclohexanol 4-ACETAMIDOCYCLOHEXANOL N,N'-Dimethyl-1,2-cyclohexanediamine (R,R)-(-)-1,2-DIAMINOCYCLOHEXANE HYDROCHLORIDE 1,2-Cyclohexanediamine,N,N-dimethyl-,(1R,2R)-(9CI) N-(2-phenylethyl)cyclohexanamine TRANS-(1R,2R)-N,N'-BISMETHYL-1,2-CYCLOHEXANEDIAMINE HCL (2R,3R)-(+)-2,3-BUTANEDIAMINE DIHYDROCHLORIDE CHEMBRDG-BB 4024898 TRANS-4-(METHYLAMINO)CYCLOHEXANOL (3,4-DICHLOROPHENYL)ACETALDEHYDE CHEMBRDG-BB 4018237

  • SPIRADOLINE MESYLATE
  • U-62066
  • (+/-)-(5ALPHA,7ALPHA,8BETA)-3,4-DICHLORO-N-METHYL-N-(7-[1-PYRROLIDINYL]-1-OXASPIRO[4.5]DEC-8-YL)BENZENEACETAMIDE MESYLATE
  • U-62066 (mesylate)
  • rel-3,4-dichloro-N-methyl-N-[(5S,7R,8R)-7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide,monomethanesulfonate
  • 87173-97-5