2-PHENYL-5-OXAZOLONE

Product Name: 2-PHENYL-5-OXAZOLONE
CAS No.: 1199-01-5
Chemical Name: 2-PHENYL-5-OXAZOLONE
Synonyms: Phenyloxazolone;2-phenyloxazolone;2-PHENYL-5-OXAZOLONE;2-phenyl-5(4h)-oxazolon;2-Phenyl-5(4H)-oxazolone;2-PHENYL-2-OXAZOLIN-5-ONE;2-PHENYL-4H-OXAZOL-5-ONE;2-Phenyl-2-oxazoline-5-one;2-phenyl-4H-1,3-oxazol-5-one
CBNumber: CB7469864
Molecular Formula: C9H7NO2
Formula Weight: 161.16
MOL File: 1199-01-5.mol

More

Less

2-PHENYL-5-OXAZOLONE Property

Melting point:: 89-92°C
Boiling point:: 248.1±23.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Soluble in most common organic solvents.
pka: 2.56±0.20(Predicted)
Appearance: Off-white to light yellow Solid
Sensitive: Air Sensitive
BRN: 128465
EPA Substance Registry System: 5(4H)-Oxazolone, 2-phenyl- (1199-01-5)

More

Less

Safety

Safety Statements: 22-24/25
TSCA: Yes

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S554243
Product name: 2-PHENYL-2-OXAZOLIN-5-ONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $143
Updated: 2025/07/31

Sigma-Aldrich

Product number: S301604
Product name: 2-PHENYL-4H-OXAZOL-5-ONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $30.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: S554243
Product name: 2-PHENYL-2-OXAZOLIN-5-ONE
Purity: Aldrich
Packaging: 250mg
Price: $139
Updated: 2024/03/01

Sigma-Aldrich

Product number: S301604
Product name: 2-PHENYL-4H-OXAZOL-5-ONE
Purity: Aldrich
Packaging: 25mg
Price: $29.8
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: CHM0021777
Product name: 2-PHENYL-5-OXAZOLONE
Purity: 95.00%
Packaging: 1G
Price: $652.46
Updated: 2021/12/16

More

Less

2-PHENYL-5-OXAZOLONE Chemical Properties,Usage,Production

Uses

2-Phenyl-5-oxazolone is a reagent used as a masked glycine equivalent and for the formation of heterocyclic structures, it can be used to produce 4-benzylidene-2-phenyl-4H-oxazol-5-one.

Definition

ChEBI: A 1,3-oxazole having a phenyl substituent at the 2-position and an oxo group at the 5-position. Note that phenyloxazolone is commonly used as a synonym for 4-(ethoxymethylene)-2-phenyloxazol-5-one (PhOx).

Synthesis

495-69-2

1199-01-5

The general procedure for the synthesis of 2-phenyl-5-azolone from equine uric acid was as follows: equine uric acid (5.0 g, 27.9 mmol) and EDCI-HCl (7.0 g, 36.3 mmol) were dissolved in dichloromethane (50 mL) and stirred for 45 min at room temperature under nitrogen protection. Upon completion of the reaction, the reaction was quenched with water. The organic layer was separated and washed twice with water and once with brine sequentially, then dried with anhydrous magnesium sulfate. After filtration, the filtrate was concentrated in vacuum to afford 2-phenyl-5-azolone as an off-white solid (4.1 g, 91% yield), which could be used in the next reaction without further purification. The nuclear magnetic resonance hydrogen spectrum (1H NMR, 600 MHz, CDCl3) data of the product were as follows: δ 7.96 (dd, J = 5.2, 3.3 Hz, 2H), 7.55 (m, 1H), 7.46 (m, 2H), 4.38 (s, 2H). Nuclear magnetic resonance carbon spectroscopy (13C NMR, 151 MHz, CDCl3) data were as follows: δ 176.00, 163.54, 132.87, 129.09, 128.88, 128.66, 127.86, 125.94, 77.37, 77.16, 76.95, 55.04.

References

[1] Organic Letters, 2016, vol. 18, # 4, p. 696 - 699
[2] Patent: WO2017/147646, 2017, A1. Location in patent: Page/Page column 42; 43
[3] Synthesis, 1982, # 3, p. 191 - 193
[4] Synthetic Communications, 1980, vol. 10, # 10, p. 761 - 766
[5] Journal of Heterocyclic Chemistry, 1994, vol. 31, # 5, p. 1145 - 1150

2-PHENYL-5-OXAZOLONE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-PHENYL-5-OXAZOLONE Suppliers

China 83 Germany 2 India 3 United Kingdom 2 United States 8 Global 98

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3921
Advantage: 50

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 42446
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

More

Less

View Lastest Price from 2-PHENYL-5-OXAZOLONE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-PHENYL-5-OXAZOLONE 1199-01-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Career Henan Chemical Co

Product: 2-PHENYL-5-OXAZOLONE 1199-01-5
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2019-12-30

Nanjing jinheyou Trading Co., Ltd.

Product: 2-PHENYL-5-OXAZOLONE 1199-01-5
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min
Supply Ability: 20kg/month
Release date: 2019-11-01

1199-01-5, 2-PHENYL-5-OXAZOLONERelated Search:

2,4-Dihydro-5-methyl-2-(4-methylphenyl)-3H-pyrazol-3-one 2-PHENYL-5-OXAZOLONE 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE 4-Benzylidene-2-phenyl-4,5-dihydro-1,3-oxazol-5-one S-DIPHENYLCARBAZONE Antipyrine METHAQUALONE 5-Oxo-1-phenyl-2-pyrazolin-3-carboxylic acid 4-BENZYL-2-PHENYL-2-OXAZOLINE-5-ONE 4-(2,4-DIMETHOXYBENZYLIDENE)-5-OXO-2-PHENYLOXAZOLINE 4-(4-METHOXYBENZYLIDENE)-2-PHENYL-2-OXAZOLIN-5-ONE 4-(3,4-METHYLENEDIOXYBENZAL)-2-PHENYL-5-OXAZOLONE,4-(3,4-METHYLENEDIOXYBENZYLIDENE)-2-PHENYL-5-OXAZOLONE 4-BENZAL-2-PHENYL-5-OXAZOLONE 4-METHYL-2-PHENYL-5-OXAZOLONE 4-METHYL-2-PHENYL-5-OXAZOLONE AKOS BBS-00001160 AKOS BBS-00001159 AURORA 682

2-phenyl-5(4h)-oxazolon

2-phenyloxazolone

2-PHENYL-5-OXAZOLONE

2-PHENYL-4H-OXAZOL-5-ONE

2-PHENYL-2-OXAZOLIN-5-ONE

2-Phenyl-2-oxazoline-5-one

2-Phenyl-5(4H)-oxazolone

Phenyloxazolone

2-phenyl-4H-1,3-oxazol-5-one

1199-01-5