alloc-L-Val-L-Ala-PABOH

Product Name: alloc-L-Val-L-Ala-PABOH
CAS No.: 1343407-91-9
Chemical Name: alloc-L-Val-L-Ala-PABOH
Synonyms: Alloc-Val-Ala-pAB;ALLoc-L-Val-L-Ala-PAB;Alloc-L-Val-Ala-PAB-OH;alloc-L-Val-L-Ala-PABOH;N-(Allyloxycarbonyl)-L-valyl-[4-(hydroxymethyl)phenyl]-L-alaninamide;L-Alaninamide, N-[(2-propen-1-yloxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-;Allyl [(S)-1-[[(S)-1-[[4-(Hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]amino]-3-methyl-1-oxo-2-butyl]carbamate;prop-2-en-1-yl N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamate;allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate;prop-2-enyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
CBNumber: CB74718506
Molecular Formula: C19H27N3O5
Formula Weight: 377.43
MOL File: 1343407-91-9.mol

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alloc-L-Val-L-Ala-PABOH Property

Melting point:: 227 °C
Boiling point:: 660.3±55.0 °C(Predicted)
Density: 1.194±0.06 g/cm3(Predicted)
pka: 11.52±0.46(Predicted)
form: powder to crystal
color: White to Almost white
InChIKey: YWKFGPPNBVPIDP-BBRMVZONSA-N
SMILES: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(OCC=C)=O)C1=CC=C(CO)C=C1

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Safety

HS Code: 2924.29.7790

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3347
Product name: Alloc-Val-Ala-PAB-OH
Packaging: 250MG
Price: $491
Updated: 2025/07/31

AK Scientific

Product number: 6462DT
Product name: Prop-2-enylN-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate
Packaging: 250mg
Price: $684
Updated: 2021/12/16

ChemScene

Product number: CS-0093977
Product name: Allyl((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate
Packaging: 1g
Price: $1365
Updated: 2021/12/16

Acrotein

Product number: AS01376
Product name: Alloc-Val-Ala-pAB
Purity: 97%
Packaging: 0.25g
Price: $293.3
Updated: 2021/12/16

Acrotein

Product number: AS01376
Product name: Alloc-Val-Ala-pAB
Purity: 97%
Packaging: 0.5g
Price: $440
Updated: 2021/12/16

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alloc-L-Val-L-Ala-PABOH Chemical Properties,Usage,Production

Description

Alloc-Val-Ala-PAB-OH is a peptide linker with a terminal Alloc protecting group. The peptide chain can act as a cleavable linker in drug design, such as in antibody drug conjugates (ADC). The Alloc group is stable to treatment with piperidine and TFA, and can be removed in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3. This allows the allyl system to work orthogonality with the most common protecting groups.

Uses

Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs). The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

alloc-L-Val-L-Ala-PABOH Preparation Products And Raw materials

Raw materials

Preparation Products

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alloc-L-Val-L-Ala-PABOH Suppliers

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View Lastest Price from alloc-L-Val-L-Ala-PABOH manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Alloc-Val-Ala-PAB 1343407-91-9
Price: US $0.00/g
Min. Order: 1g
Purity: >95.00%
Supply Ability: 1g
Release date: 2024-03-29

1343407-91-9, alloc-L-Val-L-Ala-PABOHRelated Search:

alloc-L-Val-L-Ala-PABOH

Alloc-Val-Ala-pAB

prop-2-enyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

L-Alaninamide, N-[(2-propen-1-yloxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-

N-(Allyloxycarbonyl)-L-valyl-[4-(hydroxymethyl)phenyl]-L-alaninamide

allyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

Alloc-L-Val-Ala-PAB-OH

Allyl [(S)-1-[[(S)-1-[[4-(Hydroxymethyl)phenyl]amino]-1-oxo-2-propyl]amino]-3-methyl-1-oxo-2-butyl]carbamate

prop-2-en-1-yl N-[(1S)-1-{[(1S)-1-[(4-(hydroxymethyl)phenyl)carbamoyl]ethyl]carbamoyl}-2-methylpropyl]carbamate

ALLoc-L-Val-L-Ala-PAB

1343407-91-9

ADCs Linkers