IRAK4 ANTIBODY
Source Reactivity Background References- Product Name
- IRAK4 ANTIBODY
- Chemical Name
- IRAK4 ANTIBODY
- Synonyms
- IRAK4 ANTIBODY;Mouse Monoclonal IRAK4 Antibody
- CBNumber
- CB74721717
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb97354
- Product name
- IRAK4 antibody
- Purity
- Ascitic fluid
- Packaging
- 100μL
- Price
- $370.6
- Updated
- 2021/12/16
- Product number
- orb13516
- Product name
- IRAK4 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb13516
- Product name
- IRAK4 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
IRAK4 ANTIBODY Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Interleukin-1 receptor-associated kinase is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor. The mammalian family of IRAK molecules contains four members. The binding of IL-1 to IL-1 receptor type I initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs. IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases.Upon IL-1R/TLR ligation, IRAK1 and IRAK4 are rapidly recruited to the receptor by the adaptor MyD88. IRAK1 is phosphorylated by IRAK4 at Thr209 and Thr387, followed by sequential autohyperphosphorylation in various domains.
References
[1] Dinarello, C.A. (1996) Blood 87, 2095-147.
[2] Takaesu, G. et al. (2001) Mol Cell Biol 21, 2475-84.
[3] Janssens, S. and Beyaert, R. (2003) Mol Cell 11, 293-302.
[4] Gottipati, S. et al. (2008) Cell Signal 20, 269-6.
[5] Kollewe, C. et al. (2004) J Biol Chem 279, 5227-36.
IRAK4 ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
IRAK4 ANTIBODY Suppliers
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