Pharmacology and mechanism of action Indications Side effects Contraindications Interactions Preparations References
ChemicalBook > CAS DataBase List > Trichlorfon

Trichlorfon

Pharmacology and mechanism of action Indications Side effects Contraindications Interactions Preparations References
Product Name
Trichlorfon
CAS No.
52-68-6
Chemical Name
Trichlorfon
Synonyms
DEP;TRICHLORPHON;METRIFONATE;Trichlorophon;dimethyl ester;Dipterex;TRICHLOROFON;chlorophos;DETF;Neguvon
CBNumber
CB7472545
Molecular Formula
C4H8Cl3O4P
Formula Weight
257.44
MOL File
52-68-6.mol
More
Less

Trichlorfon Property

Melting point:
77-81 °C
Boiling point:
100°C
Density 
1.73
vapor pressure 
2.1×10-4Pa (20 °C)
refractive index 
1.3439
storage temp. 
2-8°C
solubility 
Freely soluble in water, very soluble in methylene chloride, freely soluble in acetone and in ethanol (96 per cent).
pka
6 (est.)
form 
solid
color 
Crystals
Water Solubility 
Slightly soluble. 1-5 g/100 mL at 21 ºC
Merck 
13,9696
BRN 
1709434
Stability:
Light Sensitive
IARC
3 (Vol. 30, Sup 7) 1987
NIST Chemistry Reference
Metrifonate(52-68-6)
EPA Substance Registry System
Trichlorfon (52-68-6)
More
Less

Safety

Hazard Codes 
Xn,N
Risk Statements 
22-43-50/53
Safety Statements 
24-37-60-61-2
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
RTECS 
TA0700000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29319090
Hazardous Substances Data
52-68-6(Hazardous Substances Data)
Toxicity
LD50 in male, female rats (mg/kg): 630, 560 orally (Gaines)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
45698
Product name
Trichlorfon
Purity
PESTANAL?, analytical standard
Packaging
50mg
Price
$62.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1680801
Product name
Trichlorfon
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$381
Updated
2024/03/01
TRC
Product number
T773855
Product name
Trichlorfon
Packaging
25g
Price
$460
Updated
2021/12/16
TRC
Product number
T773855
Product name
Trichlorfon
Packaging
5g
Price
$215
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PST0001115
Product name
TRICHLORFON
Purity
95.00%
Packaging
100G
Price
$2607.78
Updated
2021/12/16
More
Less

Trichlorfon Chemical Properties,Usage,Production

Pharmacology and mechanism of action

Metrifonate is an organophosphorus compound, first introduced as an insecticide in 1952 and a little later as an anthelminthic. Early clinical studies have reported it to be effective against a wide number of helminthic infections including schistosomiasis, ascariasis, ancylostomiasis, and trichuriasis[1] .The drug has been tried in onchocerciasis with limited success [2]. It is also an experimental drug in Alzheimer’s disease[3]. Today, it is mainly used against Schistosoma (S) haematobium. The mechanism of action of metrifonate is unknown. The only pharmacological action described hitherto is its inhibitory effect on cholinesterases, which is due to its rearrangement product, dichlorvos. Dichlorvos, as a drug is used widely in veterinary medicine and has been given to man as a slow release preparation [4, 5]. In vitro, metrifonate paralyses both S. haematobium and S. mansoni [6]. However, clinically it is effective only against S. haematobium. Although this paradox has been explained to be due to the different locations of the two worms in man [7, 8], recent reports suggest that S. haematobium may be more sensitive to metrifonate than S. mansoni because of much higher levels of cholinesterase activity in its tegument [9].

Indications

For the treatment of Schistosoma haematobium infections. During mass treatment programmes, when cost is a major factor, metrifonate may be preferred over praziquantel. When radical treatment is desired and cost is not a problem, praziquantel is the first drug of choice, i.e. in places where re-infection is not expected.

Side effects

Despite extensive toxicological and clinical studies no major side effects have been observed with the recommended dose[10, 11]. One of the most important side effects of the drug, is its effect on blood cholinesterases. Soon after its intake, both plasma and erythrocyte cholinesterase levels are inhibited to zero and to 80%, respectively. Normal plasma cholinesterase levels return after 4 weeks, but it takes longer for the recovery of the erythrocyte cholinesterase [12]. Although no correlation seems to exist between the dose and the degree of cholinesterase inhibition, a good relationship was found between the occurrence of side effects and the plasma levels of the drug [13]. Side effects commonly reported include nausea, vomiting, headache, abdominal pain, vertigo, and fatigue. They are low in frequency and severity and they usually disappear spontaneously within a few hours after drug intake. In the case of metrifonate intoxication, pralidoxime iodide is used as an antidote (1 g is injected intravenously in 2 minutes. The dose may be repeated after 20 minutes if symptoms persist). In addition, atropine should be given in high doses, i.e. 2–4 mg i.v. every 3–10 minutes to a maximum daily dose of 50 mg.

Contraindications

Metrifonate should not be given to patients taking suxamthonium. In areas where organophosphorus insecticides have been sprayed, the community may already have low levels of blood cholinesterases. Special precautions are needed in such situations.

Interactions

Metrifonate prolongs the muscle-relaxing effect of succinylcholine.

Preparations

• Bilarcil® (Bayer). Tablets 100 mg.

References

1. Cerf J, Lebrun A, Dierichx J (1962). A new approach to helminthiasis control: The use of an organophosphorus compound. Am J Trop Med Hyg, 11, 514–517.
2. Awadzi K, Gilles HM (1980). The chemotherapy of onchocerciasis, III: a comparative study of diethylcarbamazine DEC and metrifonate. Ann Trop Med Parasitol, 74, 210–217.
3. Moriearty PL, Womack CL, Dick BW, Colliver JA, Robbs RS, Becker RE (1991). Stability of peripheral hematological parameters after chronic acetylcholinesterase inhibition in man. Am J Hematol, 37, 280–282.
4. Cervoni WA, Oliver-Gonzalez J, Kaye S, Slomka MB (1969). Dichlorvos as a single-dose intestinal anthelminthic therapy for man. Am J Trop Med Hyg, 18, 912–919.
5. Chavarria APA, Swartzwelder JC, Villarejos VM, Kotcher E, Arguedas J (1969). Dichlorvos, an effective broad spectrum anthelminthic. Am J Trop Med Hyg, 18, 907–911.
6. Bueding E, Liu CL, Rogers SH (1972). Inhibition by metrifonate and dichlorvos of cholinesterases in schistosomes. Br J Pharmacol, 46, 480–487.
7. Forsyth DM, Rashid C (1967). Treatment of urinary schistosomiasis with trichlorofon. Lancet, ii, 909–912.
8. Feldmeier H, Doehring E, Daffalla AA, Omer AHS, Dietrich M (1982). Efficacy of metrifonate in urinary schistosomiasis: Comparison of reduction of Schistosoma haematobium and S. mansoni eggs. Am J Trop Med Hyg, 31, 1188–1194.
9. Camacho M, Tarrab-Hazdai R, Espinoza B, Arnon R, Agnew A (1994). The amount of acetylcholinesterase on the parasite surface reflects the differential sensitivity of schistosome species to metrifonate. Parasitology, 108, 153–160.
10. Holmstedt B, Nordgren I, Sandoz M, Sundwall A (1978). Metrifonate: Summary of toxicological and pharmacological information available. Arch Toxicol, 41, 3–29.
11. Davis A, Bailey DR (1969). Metrifonate in urinary schistosomiasis. Bull WHO, 41, 209–224.
12. Plestina R, Davis A, Bailey DR (1972). Effect of metrifonate on blood cholinesterases in children during the treatment of schistosomiasis. Bull WHO, 46, 747–759.
13. Aden Abdi Y, Villén T, Ericsson , Gustafsson LL, Dahl-Puustinen M-L (1990). Metrifonate in healthy volunteers: interrelationship between pharmacokinetic properties, cholinesterase inhibition and side effects. Bull WHO, 68, 731–736.

Description

Trichlorfon is a colorless crystalline powder. It is soluble in water (120 g/L) and most organic solvents, except aliphatic hydrocarbons. Log Kow = 0.43. Trichlorfon is rapidly converted to dichlorvos by alkalis (2) and then hydrolyzed; DT50 (22 ?C) values at pH 4, 7, and 9 are 510 d, 46 h, and <30 min, respectively.

Chemical Properties

White or almost white, crystalline powder.

Chemical Properties

Trichlorfon is a white to pale yellow crystalline solid.

Uses

Insecticide used to control ?ies and roaches.

Uses

One of the biologically active forms of nicotinic acid. Differs from NAD by an additional phosphate group at the 2?position of the adenosine moiety. Serves as a coenzyme of hydrogenases and dehydrogenases. Present in living cells primarily in the r

Uses

anticholinergic, urinary incontenance therapy

Uses

Trichlorfon is used to control a wide range of insects in many crops and to control household pests, flies in animal houses and ectoparasites in domestic animals.

Uses

Trichlorfon is an irreversible organophosophate acetylcholinesterase inhibitor and the prodrug of Dichlorvos (D435950). Trichlorfon have also shown potential actions to be utilized as an effective org anophosphorus pesticide.

Indications

Metrifonate is an organophosphorous compound that is effective only in the treatment of S. haematobium. The active metabolite, dichlorvos, inactivates acetylcholinesterase and potentiates inhibitory cholinergic effects. The schistosomes are swept away from the bladder to the lungs and are trapped. Therapeutic doses produce no untoward side effects except for mild cholinergic symptoms. It is contraindicated in pregnancy, previous insecticide exposure, or with depolarizing neuromuscular blockers. Metrifonate is not available in the United States.

Definition

ChEBI: A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.

Antimicrobial activity

Useful activity is restricted to Schistosoma haematobium. It has little activity against other schistosomes. Although it exhibits activity against several other helminths, it is not used for their treatment.

General Description

Metrifonate is an organophosphate thatwas originally developed to treat schistosomiasis under thetrade name Bilarcil. It is an irreversible cholinesteraseinhibitor with some selectivity for BuChE over AChE. Itachieves sustained cholinesterase inhibition by its nonenzymaticmetabolite dichlorvos (DDVP), a long-actingorganophosphate. Its use in mild-to-moderate Alzheimerdisease was suspended recently because of adverse effectsexperienced by several patients during the clinical evaluationof this product. Toxicity at the neuromuscular junctionis probably attributable to the inhibition by the drug of neurotoxicesterase, a common feature of organophosphates.

General Description

Chlorophos is a white crystalline solid. Soluble in water, benzene, chloroform, ether; insoluble in oils. Chlorophos is a wettable powder. Chlorophos can cause illness by inhalation, skin absorption and/or ingestion. Chlorophos is used as a pesticide.

Air & Water Reactions

Chlorophos decomposes at higher temperatures in water and at pH <5.5. Chlorophos is sensitive to prolonged exposure to moisture. Chlorophos is unstable in alkaline solutions.

Reactivity Profile

Chlorophos is incompatible with alkalis. Chlorophos is corrosive to black iron and mild steel. Chlorophos is corrosive to metals. Chlorophos is subject to hydrolysis.

Health Hazard

INHALATION, INGESTION, AND SKIN ABSORPTION. Inhibits cholinesterase. Headache, depressed appetite, nausea, miosis are symptoms of light exposures. Moderate effects are peritoneal paralysis, diarrhea, salivation, lacrimation, sweating, dyspnea, substernal tightness, slow pulse, tremors, muscular cramps and ataxia. Severe symptoms are: pyrexia, cyanosis, pulmonary edema, areflexia, loss of sphincter control, paralysis, coma, heart block, shock and respiratory failure. EYES: Increases permeability of blood vessels in anterior eye. Reduces corneal sensitivity with glaucoma, abnormalities in intraocular tension or decreased visual acuity.

Fire Hazard

Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.

Agricultural Uses

Insecticide, Anthelmintic: Not approved for use in EU countries . Registered for use in the U.S. except California. Trichlorfon has non-agriculture uses on golf course turf, home lawns and similar venues, and in non-food contact areas of food and meat processing plants. Also on ornamental shrubs and plants, and ornamental and bait fish ponds. Overseas, trichlorfon is used as cattle pour-on, which is classified as a food-use. It is used against insects such as lepidopteran larvae (caterpillars), white grubs, mole crickets, cattle lice, sod webworms, leaf miners, stink bugs, flies, ants, cockroaches, earwigs, crickets, diving beetles, water scavenger beetles, water boatman, backswimmers, water scorpions, giant water bugs and pillbugs. All food and feed uses in the U.S. were voluntarily canceled November 21, 1995. It was used on Brussels sprouts, barley, beets, blueberries, beans (dryand snap), corn, field corn, popcorn, sweet corn, cotton, cow peas, lima beans, tomatoes, cabbage, carrots (including tops), cauliflower, collards, cowpeas, southern peas, blackeyed peas, crowder peas, pumpkins, collards, lettuce and alfalfa, cotton, peanuts, peppers, pumpkins, tobacco, soybeans and treatment to manure. U.S. Maximum Allowable Residue Levels for the residues of Trichlorfon [40 CFR 180.198]: in or on the following raw agricultural commodities: cattle, fat 0.1ppm (negligible residue); cattle, meat byproducts 0.1ppm (negligible residue); and cattle, meat 0.1ppm (negligible residue)

Pharmaceutical Applications

An organophosphorus compound. It is soluble in water and stable at room temperature. At higher temperatures it decomposes to the insecticide dichlorvos.

Trade name

AEROL 1 (PESTICIDE)®; AGROFOROTOX®; ANTHON®; BAY 15922®; BAYER 15922®; BAYER L 13/59®; BILARCIL®; BOVINOX®[C]; BRITON®; BRITTEN®; CEKUFON®; CHLORAK®; CHLOROFTALM®; CICLO-SOM®; COMBOT®; COMBOT EQUINE®; DANEX®[C]; DEP®; DEPTHON®; DIMETOX®; DIPTEREX®; DIPTEREX® 50; DIPTEVU®; DITRIFON®; DYLOX®; DYLOX-METASYSTOX-R®; DYREX®; DYVON®; EQUINO-ACID®; EQUINO-AID®; FLIBOL E®; FLIEGENTELLE®; FOROTOX®; FOSCHLOR®; FOSCHLOR R®; FOSCHLOR R-50®; LEIVASOM®; LOISOL®; MASOTEN®[C]; MAZOTEN®; NEGUVON®; NEGUVON A®; PHOSCHLOR R50®; PROXOL®; RICIFON®; RITSIFON®; SATOX 20WSC®; SOLDEP®; SOTIPOX®; TRICHLORPHON FN®; TRINEX®; TUGON®; TUGON FLY BAIT®; TUGON STABLE SPRAY®; VERMICIDE BAYER 2349®; VOLFARTOL®; VOTEXIT®; WEC 50®; WOTEXIT®

Mechanism of action

In vivo, metrifonate rapidly rearranges to O,O-dimethyl O-(2,2-dichlorovinyl) phosphate, which is a potent inhibitor of schistosome acetylcholinesterase. This paralyzes the parasites because of the accumulation of acetylcholine, which functions as inhibitory transmitter . Trade name: Bilarcil (Bayer).

Pharmacokinetics

Metrifonate is rapidly absorbed after oral administration, achieving a peak concentration in plasma within 1–2 h. It undergoes chemical transformation to dichlorvos, which is the active molecule. Dichlorvos is rapidly and extensively metabolized and excreted mainly in the urine.

Clinical Use

Urinary schistosomiasis (especially mass chemotherapy control programs)

Side effects

Various side effects such as abdominal pain, gastrointestinal upsets and vertigo occur in many patients. As the worms release their hold of the veins in the bladder they pass through the blood system to the lungs, where they disintegrate; this may cause some of the side effects. Cholinesterase levels in the blood and on erythrocytes are depressed, but the significance of this is unknown.

Safety Profile

Poison by ingestion, inhalation, inti-aperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by skin contact. Human systemic effects: true cholinesterase. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental carcinogenic and tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits very toxic fumes of Cland POx.

Potential Exposure

Trichlorfon is used as an agricultural and forest insecticide.

Carcinogenicity

When rats were fed diets that contained 0, 50, 100, 200, 250, 400, 500, or 1000 ppm (equivalent to about 0.5, 12.5, 25, or 50 mg/kg/day) for 17 or 24 months, no treatment-related effects occurred in those fed 50–250 ppm . Histopathological results suggested the occurrence of mammary tumors in rats fed 400, 500, and 1000 ppm. In another study, when rats were fed diets containing 0, 50, 250, 500, or 1000 ppm (equivalent to about 2.5, 12.5, 25, or 50 mg/kg/day) trichlorfon for 24 months, no treatment-related effects other than whole-blood cholinesterase depression at 1000 ppm occurred . There was no increase in the incidence of either benign or malignant tumors, including mammary tumors.

Environmental Fate

Soil. Trichlorfon degraded in soil to dichlorvos (alkaline conditions) and desmethyl dichlorvos (Mattson et al., 1955).
Plant. In cotton leaves, the metabolites identified included dichlorvos, phosphoric acid, O-demethyl dichlorvos, O-demethyl trichlorfon, methyl phosphate and dimethyl phosphate (Bull and Ridgway, 1969). Chloral hydrate and trichloroethanol were r
Pieper and Richmond (1976) studied the persistence of trichlorfon in various foliage following an application rate of 1.13 kg/ha. Concentrations of the insecticide found at day 0 and 14 were 81.7 ppm and 7 ppb for willow foliage, 12.6 ppm and 670 ppb for
Chemical/Physical. At 100°C, trichlorfon decomposes to chloral. Decomposed by hot water at pH <5 forming dichlorvos (Worthing and Hance, 1991).

Metabolic pathway

The metabolism of trichlorfon has been reviewed by Zayed et al. (1967), Sawicki (1973) and Zayed (1974). Trichlorfon is a non-systemic insecticide with favourable mammalian toxicity. There is considerable evidence that trichlorfon requires in vivu activation via dehydrochlorinatation to yield dichlorvos which is the active acetylcholinesterase inhibitor. This reaction is quite facile in slightly basic solution and the subsequent routes for the metabolism of trichlorfon are apparently the same as those of dichlorvos. However, there has been considerable controversy on the role played by this reaction in vivu since many workers have failed to identify dichlorvos as a metabolite in plants, mammals or insects treated with trichlorfon. It was realised that trichlorfon was a very much poorer inhibitor of acetylcholinesterase than dichlorvos and most considered that its insecticidal activity must be due to metabolism to dichlorvos as an activating step in an analogous way that phosphorothioates are metabolised to phosphates. Metcalf et al. (1959) and Miyamoto (1959) proposed that trichlorfon was totally inactive as an inhibitor of acetylcholinesterase and that any inhibition seen in vitru was due to some conversion to dichlorvos during the course of the assay for anticholinesterase activity. Metcalf et al. (1959) also reported the identification of dichlorvos in trichlorfon-treated houseflies. This conclusion was by no means universal and Arthur and Casida (1957) argued that trichlorfon was the active acetylcholinesterase inhibitor and the identification of a glucuronide conjugate of trichloroethanol was evidence that the primary route of stage I metabolism was hydrolysis of the P< bond. Other work, however, has provided evidence for the in vivu production of dichlorvos and it seems probable that the failure of some experiments to detect it is due to its rapid metabolism, resulting in a very low steadystate concentration. The metabolism of trichlorfon can be envisaged as being either through a deactivation route via demethylation and/or conjugation followed by breakdown of the demethylated products or an activation reaction to yield dichlorvos which is then degraded via a hydrolytic mechanism to yield dimethyl phosphate and dichloroacetaldehyde or demethylated by glutathione-S-methyl transferase. These competing reactions have been investigated in mammals and insects and it is the balance of activation and degradative metabolism which confers the favourable mammalian toxicity of trichlorfon in comparison with that of dichlorvos.

Metabolism

Trichlorfon administered to mammals is rapidly metabolized and excreted almost completely in the urine within 6 h. Majormetabolites are dimethyl hydrogen phosphate, methyl dihydrogen phosphate, and conjugates of dichloroacetic acid and trichloroethanol. Trichlorfon is rapidly broken down in soil.

Shipping

UN2783 Organophosphorus pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Toxicity evaluation

The acute oral LD50 for rats is about 450 mg/kg. Inhalation LC50 (1 h) for rats is >0.5 mg/L air. NOEL (2 yr) for rats is 100 mg/kg diet (5 mg/kg/d). ADI is 0.01 mg/kg b.w.

Degradation

Trichlorfon is subject to hydrolysis and dehydrochlorination. Decomposition proceeds more rapidly with heating and above pH 6. It is rapidly converted by alkalis to dichlorvos (2) which is then hydrolysed. DT50 s at pH 4,7 and 9 were 510 days, 46 hours and <30 min respectively at 20 °C. Photolysis is slow (PM).
Trichlorfon undergoes a facile rearrangement in the presence of mild base or heat to yield dichlorvos (2) and one mole of HCI (Barthel et al., 1955; Lorenz et al., 1955; Mattson et al., 1955). This reaction was shown to be first order in both trichlorfon concentration and [OH-] with a calculated t1/2 of 5 hours at pH 7.0 (37 °C) (Miyamoto, 1959). A mechanism for this reaction is shown in Scheme 1.

Incompatibilities

This chemical may be characterized as an organo-phosphate or-chlorine compound. Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducin g agents such as hydrideds and active metals. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.Alkaline materials: lime, lime sulfur, etc. Corrosive to iron, steel and possibly to other metals.

Waste Disposal

Add a combustible solvent and burn in a furnace equipped with an afterburner and an alkali scrubber.In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

Trichlorfon Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Trichlorfon Suppliers

Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
More
Less

View Lastest Price from Trichlorfon manufacturers

Hebei Mojin Biotechnology Co., Ltd
Product
Trichlorfon 52-68-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-06-20
Hebei Guanlang Biotechnology Co., Ltd.
Product
Trichlorfon 52-68-6
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2021-07-29
Xingtai Haoxun Import and Export Trade Co., Ltd.
Product
Metrifonate Bree 52-68-6
Price
US $1.00/KG
Min. Order
100g
Purity
99%
Supply Ability
10ttons
Release date
2020-07-14

52-68-6, TrichlorfonRelated Search:


  • (1-Hydroxy-2,2,2-trichloroethyl)phosphonic acid, dimethyl ester
  • (1-hydroxy-2,2,2-trichloroethyl)-phosphonicacidimethylester
  • (2,2,2-Trichloro-1-hydroxyethyl)phosphonate, dimethyl ester
  • bayerl1359
  • Bilarcil
  • Bovinox
  • briten
  • Briton
  • britten
  • Cekufon
  • chlorak
  • chlorfos
  • Chloroftalm
  • Chlorophosciclosom
  • chlorophose
  • Chlorophthalm
  • Chloroxyphos
  • ciclosom
  • Clorofos
  • Combot
  • combotequine
  • Danex
  • denkaphon
  • DEP (Pesticide)
  • depthon
  • DETF
  • dicontalfort
  • Dimethoxy-(2,2,2-trichloro-1-hydroxyethyl)phosphine oxide
  • dimethoxy-2,2,2-trichloro-1-hydroxy-ethylphosphineoxide
  • dimethoxy-2,2,2-trichloro-1-hydroxy-ethyl-phosphineoxide
  • Dimethyl (1-hydroxy-2,2,2-trichloroethyl)phosphonate
  • Dimethyl (trichlorohydroxyethyl)phosphonate
  • dimethyl1-hydroxy-2,2,2-trichloroethylphosphonate
  • dimethyltrichlorohydroxyethylphosphonate
  • dimetox
  • Dipterax
  • Dipteres
  • Dipterex 50
  • dipterex50
  • Diptevur
  • Ditrifon
  • ditriphon50
  • Dylox
  • dylox-metasystox-r
  • Dyrex
  • Dyvon
  • ENT 19,763
  • ent19,763
  • ent19763
  • Equino-Aid
  • Fliegenteller
  • Forotox
  • Foschlor
  • Foschlor R
  • Foschlor R-50
  • foschlor25
  • Foschlorem
  • foschlorem(polish)